Ukucindezeleka Oxidative
I-Back Clinic Oxidative Stress Chiropractic kanye neThimba Lemithi Esebenzayo. Ukucindezeleka kwe-oxidative kuchazwa njengokuphazamiseka kwebhalansi phakathi kokukhiqizwa kwe-oxygen esebenzayo (ama-radicals mahhala) kanye nokuzivikela kwe-antioxidant. Ngamanye amazwi, ukungalingani phakathi kokukhiqizwa kwama-radicals mahhala kanye nekhono lomzimba lokuphikisa noma ukukhipha imiphumela eyingozi ngokusebenzisa i-neutralization ngama-antioxidants. Ukucindezeleka okwenziwe nge-oxidative kuholela ezimweni eziningi ze-pathophysiological emzimbeni. Lezi zihlanganisa izifo ze-neurodeergenerative, okungukuthi, isifo sika-Parkinson, isifo se-Alzheimer, ukuguqulwa kwezakhi zofuzo, umdlavuza, i-chronic fatigue syndrome, i-X syndrome ebuthakathaka, ukuphazamiseka kwenhliziyo nemithambo yegazi, i-atherosclerosis, ukuhluleka kwenhliziyo, ukuhlasela kwenhliziyo, nezifo ezivuthayo. I-oxidation kwenzeka ngaphansi kwezimo eziningana:
amaseli asebenzisa i-glucose ukwenza amandla
Ukukhathala
by UDkt Alex Jimenez Heart Health , Ukucindezeleka Oxidative
Kubantu abafuna ukuthuthukisa impilo yenhliziyo, ingabe ukudla ama-prunes kungasiza ukusekela impilo yenhliziyo nemithambo yegazi?
Ama-Prunes kanye Nempilo Yenhliziyo
Ama-prunes, noma ama-plums omisiwe, ayizithelo ezinothe nge-fiber ezinomsoco kakhulu kunama-plums amasha futhi zisiza ukugayeka kokudla kanye nokuphuma kwamathumbu. (U-Ellen Lever et al., 2019 ) Ucwaningo olusha lusikisela ukuthi banganikeza okungaphezu kokukhululeka kokugaya nokuqunjelwa, ngokusho kwezifundo ezintsha ezethulwe e-American Society for Nutrition. Ukudla ama-prunes nsuku zonke kungathuthukisa amazinga e-cholesterol futhi kunciphise ukucindezeleka okwenziwe nge-oxidative nokuvuvukala.
Ukudla ama-prunes amahlanu kuya kwayi-10 ngosuku kungase kusekele impilo yenhliziyo.
Izinzuzo zezempilo zenhliziyo zokusetshenziswa njalo zabonakala emadodeni.
Kwabesifazane asebekhulile, ukudla njalo ama-prunes akuzange kube nomthelela omubi ku-cholesterol ephelele, ushukela wegazi, namazinga e-insulin.
Olunye ucwaningo lwathola ukuthi ukudla amagremu angama-50-100 noma ama-prunes amahlanu kuya kwayishumi nsuku zonke kwakuhlotshaniswa nokuncipha kwezingozi zesifo senhliziyo. (U-Mee Young Hong et al., 2021 )
Ukuncipha kwe-cholesterol kanye nezimaka zokuvuvukala kwakungenxa yokuthuthukiswa kwamazinga e-antioxidant.
Isiphetho kwaba ukuthi ama-prunes angakwazi ukusekela impilo yenhliziyo nemithambo yegazi.
Ama-Prunes kanye nama-Plums amasha
Nakuba ucwaningo luye lwaphakamisa ukuthi ama-prunes angakwazi ukusekela impilo yenhliziyo, lokho akusho ukuthi ama-plums amasha noma ijusi ye-prune anganikeza izinzuzo ezifanayo. Kodwa-ke, azikho izifundo eziningi mayelana nezinzuzo zama-plums amasha noma ijusi ye-prune, kodwa kungenzeka ukuthi zingakwenza. Nokho, ucwaningo olwengeziwe luyadingeka. Ama-plums amasha omisiwe emoyeni oshisayo athuthukisa inani lokudla okunempilo kanye nempilo yeshalofu yesithelo, okungase kube isizathu sokuthi inguqulo eyomisiwe igcine imisoco eyengeziwe. (U-Harjeet Singh Brar et al., 2020 )
Abantu ngabanye kungase kudingeke badle ama-plums amaningi ukuze bathole izinzuzo ezifanayo.
Ukudla ama-prunes angu-5-10 kubonakala kulula kunokuzama ukulinganisa inani elifanayo, noma ngaphezulu, lamapulamu amasha.
Kodwa noma iyiphi inketho iyanconywa esikhundleni sejusi ye-prune njengoba izithelo eziphelele zine-fiber eyengeziwe, zenza umzimba uzizwe ugcwele, futhi zine-calories ephansi.
Izinzuzo Zabantu Abancane Abancane
Iningi locwaningo lwenziwe kwabesifazane nabesilisa abangemva kokuya esikhathini esingaphezu kweminyaka engama-55, kodwa abantu abasebasha nabo bangazuza ngokudla ama-prunes. Ukudla okucebile izithelo nemifino kubhekwa njengokunempilo, ngakho-ke ukwengeza ama-prunes ekudleni komuntu kuzofaka izinzuzo zezempilo. Kubantu abangawathandi ama-prunes, izithelo ezinjengama-apula namajikijolo nazo ziyanconywa ngempilo yenhliziyo. Kodwa-ke, izithelo zakha ingxenye eyodwa kuphela yokudla, futhi kubalulekile ukugxila ekudleni okulinganiselayo nemifino, imifino, namafutha enhliziyo enempilo. Ama-prunes aqukethe i-fiber eningi, ngakho-ke abantu bayanconywa ukuthi bawangeze kancane kancane esimisweni sabo sansuku zonke, njengoba ukwengeza kakhulu ngesikhathi esisodwa kungaholela ekubambeni, ukuqunjelwa, kanye/noma. ukuqunjelwa .
Ukunqoba Ukuhluleka Kwenhliziyo Eminyene
VIDEO
Okubhekwayo
U-Lever, E., Scott, S. M., Louis, P., Emery, P. W., & Whelan, K. (2019). Umthelela wama-prunes ekuphumeni kwendle, isikhathi sokuhamba kwamathumbu kanye ne-gastrointestinal microbiota: Uhlolo olulawulwa ngokungahleliwe. Ukudla okunempilo komtholampilo (Edinburgh, Scotland), 38(1), 165–173. doi.org/10.1016/j.clnu.2018.01.003
Hong, M. Y., Kern, M., Nakamichi-Lee, M., Abbaspour, N., Ahouraei Far, A., & Hooshmand, S. (2021). Ukusetshenziswa KwePlum Eyomile Kuthuthukisa Ingqikithi Ye-Cholesterol kanye Ne-Antioxidant Capacity futhi Yehlisa Ukuvuvukala Kwabesifazane Abanempilo Base-Postmenopausal. Ijenali yokudla komuthi, 24(11), 1161-1168. doi.org/10.1089/jmf.2020.0142
U-Harjeet Singh Brar, u-Prabhjot Kaur, u-Jayasankar Subramanian, u-Gopu R. Nair no-Ashutosh Singh (2020) Umphumela Wokwelashwa Kwamakhemikhali Ku-Drying Kinetics kanye Nezimpawu Ze-Physio-Chemical of Yellow European Plums, I-International Journal of Fruit Science, 20:sup2, S252-S , DOI: 279/10.1080
by UDkt Alex Jimenez I-Chiropractic , Ubuhlungu obungapheliyo , Izimo zenziwe , Impilo , Ukucindezeleka Oxidative , Ukucindezeleka , Ukwelashwa , Ividiyo , I-Viscerosomatic Reflex , Ubuhle
VIDEO
Isingeniso
UDkt Alex Jimenez, DC, uveza ukuthi ukucindezeleka okungapheli kungathinta kanjani umzimba nokuthi kuhlotshaniswa kanjani nokuvuvukala kulolu chungechunge lwezingxenye ze-2. Ingxenye 1 ihlole ukuthi ukucindezeleka kuhlobana kanjani nezimpawu ezihlukahlukene ezithinta amazinga ofuzo omzimba. Ingxenye 2 ibheka ukuthi ukuvuvukala nokucindezeleka okungapheli kuhlotshaniswa kanjani nezici ezihlukahlukene ezingaholela ekukhuleni ngokomzimba. Sidlulisela iziguli zethu kubahlinzeki bezokwelapha abaqinisekisiwe abanikeza ukwelashwa okutholakalayo kubantu abaningi abahlushwa ukucindezeleka okungapheli okuhambisana nenhliziyo nemithambo yegazi, i-endocrine, namasosha omzimba athinta umzimba kanye nokukhula kokuvuvukala. Sikhuthaza isiguli sethu ngasinye ngokukhuluma ngaso kubahlinzeki bezokwelapha abahlobene ngokusekelwe ekuhlaziyeni kwaso ngendlela efanele. Siyaqonda ukuthi imfundo iyindlela ejabulisayo uma ubuza abahlinzeki bethu imibuzo ngokwesicelo nokuqonda kwesiguli. UDkt. Jimenez, DC, usebenzisa lolu lwazi kuphela njengesevisi yezemfundo. Disclaimer
Kungasithinta Kangakanani Ukucindezeleka?
UDkt. Alex Jimenez, DC, wethula:
Intukuthelo ixhunyaniswe neziqephu ze-atrial fibrillation. Uma ucabanga ngakho, i-adrenaline iphumela emzimbeni futhi ibangele ukucinana kwenhliziyo. Inyusa izinga lokushaya kwenhliziyo. Zonke lezi zinto zingaholela ku-arrhythmia. Futhi akumele kube yi-AFib. Kungaba ama-APC nama-VPC. Manje, ucwaningo oluthakazelisa kakhulu luye lwaphuma mayelana ne-telomerase nama-telomere. I-telomeres yizigqoko ezincane kuma-chromosome, futhi i-telomerase iyi-enzyme exhunywe ekwakhekeni kwe-telomere. Futhi manje, sesingakwazi ukuqonda ngolimi lwesayensi, futhi sesiqala ukusebenzisa ubuchwepheshe nokusebenzisa isayensi ngendlela ebesingeke siyenze ngaphambili ukuze siqonde umthelela wengcindezi kuma-telomere nama-telomerase enzyme.
Izinto Eziholela Ekucindezelekeni Okungapheli
UDkt. Alex Jimenez, DC, wethula:
Kuthiwani ngobandlululo lobuhlanga la mabhokisi lapha akhombisa ukucwasa ngokobuhlanga okuphezulu okuholela ebudeni obuphansi be-telomere, iningi lethu elake lacabanga ngakho. Ngakho-ke, ubude be-telomere obufushane buholela engcupheni eyengeziwe yomdlavuza kanye nokufa okuphelele. Amazinga okutholakala komdlavuza angama-22.5 ngeminyaka eyi-1000 yomuntu eqenjini elifushane kakhulu le-telomere, ivesi 14.2 eqenjini eliphakathi, kanye no-5.1 eqenjini elide kakhulu le-telomere. Ama-telomere amafushane angaholela ekungazinzini kwechromosome futhi aphumele ekwakhekeni komdlavuza. Ngakho-ke, manje siyaqonda, ngolimi lwesayensi, umthelela wokucindezeleka ku-enzyme ye-telomerase kanye nobude be-telomere. NgokukaDkt. Elizabeth Blackburn, abesifazane abangama-58 abangaphambi kokunqamuka kokuya esikhathini babengabanakekeli bezingane zabo ezigula okungalapheki, abesifazane abanezingane ezinempilo enhle. Abesifazane babuzwa ukuthi bakubona kanjani ukucindezeleka ezimpilweni zabo nokuthi ingabe kuyayithinta yini impilo yabo ngokuthinta ukuguga kwamaselula.
Lowo kwakuwumbuzo wocwaningo njengoba bebheka ubude be-telomere ne-enzyme ye-telomerase, futhi yilokhu abakuthola. Manje, igama elingukhiye lapha liyabonwa. Akufanele sahlulele ukucindezeleka komunye nomunye. Ukucindezeleka ngokomuntu siqu, futhi ezinye zezimpendulo zethu zingase zibe ufuzo. Isibonelo, umuntu one-homozygous comps enofuzo oluvilaphayo angase abe nokukhathazeka okukhulu kunomuntu ongenalo i-polymorphism yofuzo. Umuntu one-MAOA ku-MAOB angase abe nokukhathazeka okwengeziwe kunomuntu ongenayo leyo polymorphism yofuzo. Ngakho-ke kukhona isakhi sofuzo empendulweni yethu, kodwa lokho akuthola kwaba ukucindezelwa kwengqondo okubonwayo. Futhi inani leminyaka lokunakekela izingane ezigula okungapheli lalihlotshaniswa nobude obufushane be-telomere nomsebenzi omncane we-telomerase, okunikeza inkomba yokuqala yokuthi ukucindezeleka kungaba nomthelela ekugcinweni kwe-telomere nokuphila isikhathi eside.
Ungayishintsha Kanjani Impendulo Yethu Yokucindezeleka?
UDkt. Alex Jimenez, DC, wethula:
Futhi abaningi bethu banemibono yethu yokuthi kungani lokhu kwenzeka. Futhi kungenxa yokuthi uma sicindezelekile, asisho ukuthi, “O, ngizodla amahlumela ama-brussels, futhi ngizothatha lawo mavithamini B, futhi ngizophuma ngiyozivivinya, futhi ngizokwenza ukuzindla okuthile.” Ngakho-ke ingozi ezimele ye-post-MI yomcimbi ukucindezeleka. Umqondo wethu mayelana nokucindezeleka usenza singakwazi ukusebenza ngendlela evamile futhi ungenza imizimba yethu ibe nezindaba ezithinta izitho zethu ezibalulekile, imisipha namalunga. Ngakho-ke, ukucindezeleka kungumdlali omkhulu, njengoba i-75% yokufa kwe-post-MI ihlobene nokucindezeleka, akunjalo? Ngakho-ke ubheka iziguli, manje, kufanele ubuze umbuzo: Ingabe ukucindezeleka kubangela inkinga, noma ingabe ukugula kwe-cytokine osekuholele kakade esifweni senhliziyo esibangela ukucindezeleka? Kufanele sikufake phakathi konke lokhu.
Futhi olunye ucwaningo lubheke abantu abangaphezu kuka-4,000 abangenaso isifo se-coronary ekuqaleni. Kukho konke ukwanda kwamaphuzu amahlanu esikalini sokucindezeleka, lokho kwandisa ingozi ngo-15%. Futhi labo abanamaphuzu aphezulu okudangala babenezinga eliphakeme lama-40% lokugula kwemithambo yenhliziyo kanye nezinga lokufa eliphakeme elingama-60%. Ngakho-ke ngokuvamile wonke umuntu ucabanga ukuthi ukugula kwe-cytokine okuholela ku-MI, isifo se-vascular, nokucindezeleka. Futhi-ke, yiqiniso, uma unomcimbi, futhi uphuma nenqwaba yezinkinga ezizungezile, siyazi ukuthi abantu abacindezelekile bakhuphuka ngokuphindwe kabili kokufa, ukwanda kokufa okuphindwe kahlanu ngemva kokuhlaselwa yinhliziyo, futhi imiphumela emibi ngokuhlinzwa. Kunje, yini eyafika kuqala, inkukhu noma iqanda?
Ukudangala Kuhlotshaniswa Kangakanani Nokucindezeleka Okungapheli?
UDkt. Alex Jimenez, DC, wethula:
Ukuvuvukala Kwamathumbu & Nokucindezeleka Okungapheli
UDkt. Alex Jimenez, DC, wethula:
Futhi kulokhu, babheka amazinga e-omega-3s kanye ne-vitamin D, ngakho-ke okungenani, isheke le-omega-3 kanye nezinga le-vitamin D liqinisekisiwe kuzo zonke iziguli zethu. Futhi ngokuqinisekile, uma ungathola ukuxilongwa okuphelele kokuvuvukala okubangelwa ukucindezeleka. Esinye isimo okufanele usibheke uma kukhulunywa ngokuvuvukala okubangelwa ukucindezeleka yi-osteoporosis emalungeni. Abantu abaningi abane-osteoporosis bazoba nokulahlekelwa kwemisipha, ukungasebenzi kahle kwamasosha omzimba, amafutha azungeze umugqa ophakathi, futhi ushukela ophezulu wegazi uhlotshaniswa nokuguga, futhi ungavela emazingeni aphezulu e-cortisol emzimbeni.
Izingozi eziphezulu ze-cortisol zenhliziyo ziphakeme ngokuphindwe kabili kubantu abathatha imithamo ephezulu ye-steroids. Amanani amancane e-steroids awanayo ingozi efanayo, ngakho-ke akuyona into enkulu. Yiqiniso, sizama ukukhipha iziguli zethu kuma-steroids. Kodwa iphuzu lapha ukuthi i-cortisol iyi-hormone yokucindezeleka futhi iyi-hormone yokucindezeleka ephakamisa umfutho wegazi futhi ibeka isisindo emgqeni ophakathi, isenze sibe nesifo sikashukela, ibangele ukumelana ne-insulin, futhi uhlu alupheli. Ngakho-ke, i-cortisol ingumdlali omkhulu, futhi uma kukhulunywa ngemithi esebenzayo, kufanele sibheke izivivinyo ezahlukahlukene eziphathelene namazinga aphakeme e-cortisol njengokuzwela kokudla, i-valve yesihlalo yezinsuku ezi-3, i-nutra-valve, kanye ne-adrenal stress. ukuhlolwa kwenkomba ukuze kubhekwe ukuthi kwenzekani ngeziguli. Lapho kunohlelo lwezinzwa oluphakeme olunozwela kanye ne-cortisol ephezulu, sixoxisane ngayo yonke into kusukela ku-coagulopathy kuya ekuncipheni kokushintshashintsha kwenhliziyo, ukukhuluphala okumaphakathi, isifo sikashukela, nomfutho wegazi ophakeme.
Ubudlelwano Babazali Nengcindezi Engapheli
UDkt. Alex Jimenez, DC, wethula:
Isiphetho
UDkt. Alex Jimenez, DC, wethula:
Ukucindezeleka okungapheli kungaholela ezindabeni eziningi ezingase zihlobane nokugula nokungasebenzi kahle kwemisipha namalunga. Kungathinta uhlelo lwamathumbu futhi kuholele ekuvuvukeni uma kunganakekelwa ngokushesha. Ngakho-ke uma kuziwa emthelela wokucindezeleka okuthinta ukuphila kwethu kwansuku zonke, kungaba izici eziningi, kusukela ezimeni ezingapheli kuya emlandweni womndeni. Ukudla ukudla okunomsoco okuphezulu kuma-antioxidants, ukuzivocavoca umzimba, ukujwayela ingqondo, nokuya ekwelapheni kwansuku zonke kunganciphisa imiphumela yokucindezeleka okungapheli futhi kunciphise izimpawu ezihambisanayo ezihambisanayo futhi zibangele ubuhlungu emzimbeni. Singaqhubeka nohambo lwethu lwezempilo nokuphila kahle ngaphandle kobuhlungu ngokusebenzisa izindlela ezihlukahlukene zokwehlisa ukucindezeleka okungapheli emizimbeni yethu.
Disclaimer
by UDkt Alex Jimenez I-Chiropractic , Izimo zenziwe , Impilo , Ukucindezeleka Oxidative , Ukucindezeleka , Ukwelashwa , Ividiyo , I-Viscerosomatic Reflex , Ubuhle
VIDEO
Isingeniso
UDkt. Alex Jimenez, DC, wethula ukuthi ingcindezi ingabathinta kanjani abantu abaningi futhi ihlobanise nezimo eziningi emzimbeni kulolu chungechunge lwezingxenye ezi-2. Sidlulisela iziguli zethu kubahlinzeki bezokwelapha abanezitifiketi abahlinzeka ngemithi eminingi etholakalayo kubantu abaningi abaphethwe umfutho wegazi ophakeme ohlobene nenhliziyo, i-endocrine, namasosha omzimba athinta umzimba. Sikhuthaza isiguli sethu ngasinye ngokukhuluma ngaso kubahlinzeki bezokwelapha abahlobene ngokusekelwe ekuhlaziyeni kwaso ngendlela efanele. Siyaqonda ukuthi imfundo iyindlela ejabulisayo uma ubuza abahlinzeki bethu imibuzo ngokwesicelo nokuqonda kwesiguli. UDkt. Jimenez, DC, usebenzisa lolu lwazi kuphela njengesevisi yezemfundo. Disclaimer
Ukuthi Ukucindezeleka Kuwuthinta Kanjani Umzimba
UDkt. Alex Jimenez, DC, wethula:
Kungakhathaliseki ukuthi yisiphi isenzakalo sokuqala, ingxenye ebaluleke kakhulu umbono wethu ngomcimbi. Kusho ukuthini kithi? Ingabe umbono wethu? Lapho umzimba udlula kulesi senzakalo sokuqala, kungabangela umbono ukuholela ekuphenduleni kanye nomphumela emzimbeni wethu. Ngakho-ke umbono uyikho konke njengoba sikhuluma ngokucindezeleka kanye nokusabela kokucindezeleka. Manje, sinokuphendula kwamakhemikhali okungaphezu kwe-1400 okwenzeka emzimbeni. Ngakho-ke ngenhloso yale nkulumo, sizoxoxa ngezihluthulelo ezintathu: i-adrenaline ne-neuro-adrenaline, i-aldosterone, kanye ne-cortisol.
Futhi kungani lezi zibalulekile? Ngoba konke kwalokhu kunomthelela omkhulu ezifweni zenhliziyo nemithambo yegazi. Manje, ngawo-1990, odokotela abaningi base beqala ukuqonda umphumela wokucindezeleka emzimbeni wenyama. Futhi kwenzekani kubantu lapho i-axis ye-HPA yabo ibonisa ukuthi basengozini futhi baqala ukugcwala imizimba yabo ngamahomoni okucindezeleka? Hhayi-ke, sibona i-coagulation ethuthukisiwe. Sibona ushintsho ohlelweni lwe-renin ne-angiotensin. Iyavuselela. Sibona ukuzuza kwesisindo kubantu kanye nokumelana ne-insulin. Lokho abantu abaningi abangakuqapheli ukuthi i-lipids iba yinto engavamile ngenxa yokucindezeleka. Cishe zonke iziguli zethu ziyazi ukuthi i-tachycardia ne-arrhythmia kwenzeka lapho i-adrenaline yethu igeleza, futhi umfutho wegazi wethu uyanda. Manje, cabanga ngalokhu ngolimi lwemithi.
Ngawo-1990, odokotela babenikeza i-aspirin ne-Plavix ngaleso sikhathi ukuze kuhlanganiswe. Siyaqhubeka nokuhlinzeka ngama-ACE nama-ARB ezigulini zethu. Umthelela we-cortisol ubangela ukuzuza kwesisindo kanye nokumelana ne-insulin. Sinikeza ama-statins; sinikeza i-metformin. Sihlinzeka ngama-beta blockers alokho, i-tachycardia, nama-calcium blockers alowo mfutho wegazi ophezulu. Ngakho-ke wonke ama-hormone avulwa ngenxa yengcindezi, sinomuthi esiwusebenzisayo ukulinganisa lokho. Futhi ngokungananazi, iminyaka, sasikhuluma ngokuthi ama-beta blockers ayeyinhle kangakanani inhliziyo. Nokho, uma ucabanga ngalokho, ama-beta blocker ayayivimba i-adrenaline. Ngakho-ke lapho odokotela bebheka lokhu, baqala ukucabanga, “Hhayi-ke, mhlawumbe sidinga ukuzindla nokuzindla, akunjalo? Sisebenzisa yonke le mithi, kodwa kungase kudingeke sibheke ezinye izindlela zokuguqula impendulo yokucindezeleka.”
Iyini i-Vasoconstriction?
UDkt. Alex Jimenez, DC, wethula:
Sibona umthelela we-cortisol, hhayi nje ukuphakamisa umfutho wegazi, hhayi nje kuphela ukubangela isifo sikashukela kanye nokumelana ne-insulin, kodwa futhi nokubeka amafutha esisu eduze komugqa ophakathi. Futhi-ke, njengoba uzobona emizuzwini embalwa, kukhona izixhumanisi phakathi kwezenzakalo ezicindezelayo kanye ne-arrhythmias efana ne-atrial fibrillation kanye ne-ventricular fibrillation. Ngokokuqala ngqá kwezokwelapha, kweyenhliziyo, sine-syndrome ebizwa ngokuthi i-takosubo cardiomyopathy, ebizwa ngothando ngokuthi i-break heart syndrome. Futhi lokhu kuyisifo lapho i-myocardium ithuthumela kakhulu ize ibangele ukusebenza kanzima kwe-ventricular kwesokunxele noma ukungasebenzi kahle. Futhi ngokuvamile, lokhu kubangelwa izindaba ezimbi kanye nesenzakalo esicindezelayo ngokomzwelo. Kubukeka sengathi othile udinga ukufakelwa inhliziyo. Ngakho-ke uma sicabanga ngezici zengozi ze-Framingham ezindala, sithi, yiziphi kulezi ezithintwa ingcindezi?
Izimpawu Zokucindezeleka
UDkt. Alex Jimenez, DC, wethula:
Sizokhuluma ngokushintshashintsha kwesilinganiso senhliziyo, okuba nomthelela ekucindezelekeni. Futhi-ke, ukucindezeleka kuthinta ikhono lethu lokumelana nezifo. Futhi siyazi ukuthi abantu bangaphansi kwengcindezi uma begonyiwe. Isibonelo, ama-laser e-Cleco ayasebenza kodwa awakhiqizi amasosha omzimba emgomeni lapho ecindezelekile. Futhi, yiqiniso, njengoba uzobona ngomzuzu, ukucindezeleka okukhulu kungabangela ukufa kwenhliziyo kungazelelwe, i-MI, njalonjalo. Ngakho-ke ngumdlali omubi onganakwa. Futhi ezigulini zethu eziningi, ingcindezi ishayela isitimela. Ngakho uma sikhuluma ngokudla amahlumela ama-brussels kanye nokholifulawa futhi, niyazi, imifino eminingi enamahlamvu aluhlaza, futhi othile ungaphansi kwengcindezi enkulu kangangokuthi uzama ukuthola ukuthi, “Ngizobhekana kanjani nosuku? ” Abezwa noma yiziphi ezinye izinto esizincomayo.
Ngakho-ke, ukucindezeleka okungapheli kanye nokuphazamiseka kwemizwa, kungakhathaliseki ukuthi ukucindezeleka, ukukhathazeka, noma ukwethuka, sibeka unyawo lwethu ku-accelerator futhi sivuselele isimiso sezinzwa esinozwela. Siyazi ukuthi izinto ezifanayo esizibonayo ngokuguga, njengoba uzobona emzuzwini owodwa, zixhunyaniswa namazinga akhulayo amahomoni okucindezeleka, ikakhulukazi i-cortisol. Ngakho-ke noma ngabe i-osteoporosis, ukuncipha kwamathambo, ukungasebenzi kahle kwe-endothelial, ukusebenza kweplatelet, umfutho wegazi ophakeme, ukukhuluphala okuphakathi nendawo, noma ukumelana ne-insulin, lokhu kuvela ekuphenduleni kokucindezeleka. Futhi kufanele sibe nohlelo lweziguli zethu lokuthi singakusingatha kanjani lokhu. I-American Institute of Stress ithi u-75 kuya ku-90% wakho konke ukuvakasha kwabahlinzeki bezempilo kubangelwa ukuphazamiseka okuhlobene nokucindezeleka. Futhi lokho kuphakeme kakhulu, kodwa ngokubheka iziguli nokuthi zazingena kuphi, zixoxela odokotela bazo izindaba zabo. Imiphumela iyafana; akukhathalekile ukuthi kwakuwubuhlungu bekhanda, ukuqina kwemisipha, i-angina, i-arrhythmia, noma ithumba elicasulayo; cishe njalo kwakunezisusa ezithile zokucindezeleka.
I-Acute & Chronic Stress
UDkt. Alex Jimenez, DC, wethula:
Futhi leso simo siholela kanjani ezinkingeni ezinkulu zezokwelapha njengomdlavuza, isifo senhliziyo, nokufa kungazelelwe esikhathini esizayo? Ngakho-ke babheke izehlakalo ezingama-43 ezishintsha impilo, bazibeka endaweni yokuqala, futhi baziphinda kabusha ngeminyaka yawo-1990. Futhi ezinye zazo zahlala zinjalo. Banikeze amaphuzu alungisiwe emcimbini, base bebheka izinombolo ezizoxhunyaniswa nokugula okukhulu. Ngakho, isibonelo, isenzakalo esishintsha ukuphila. Inombolo yokuqala, amayunithi ayi-100 ashintsha impilo, ukushona komlingani. Noma ubani angahambisana nalokho. Isehlukaniso sasiyinombolo yesibili, ukuhlukaniswa kwesithathu, futhi ukuphela kwelungu lomndeni eliseduze. Kodwa futhi ngiqaphele ukuthi ezinye izinto zibalwa ngalezi, okungenzeka ungalingani nazo, ukuba umcimbi omkhulu oshintsha impilo ongaba nomthelela ekuphenduleni kwengcindezi njengomshado noma umhlalaphansi.
Isiphetho
UDkt. Alex Jimenez, DC, wethula:
Disclaimer
by UDkt Alex Jimenez I-Chiropractic , Ubuhlungu obungapheliyo , Izimo zenziwe , Impilo , Ukucindezeleka Oxidative , Ukwelashwa , Ividiyo , I-Viscerosomatic Reflex , Ubuhle
VIDEO
Isingeniso
UDkt Alex Jimenez, DC, wethula ukuthi umfutho wegazi ophezulu uthinta kanjani umzimba womuntu nezinye izimbangela ezingase zikhulise umfutho wegazi ophakeme kubantu abaningi kulolu chungechunge lwezingxenye ezimbili. Sidlulisela iziguli zethu kubahlinzeki bezokwelapha abaqinisekisiwe abahlinzeka ngemithi eminingi etholakalayo kubantu abaningi abaphethwe umfutho wegazi ophakeme ohambisana nenhliziyo nemithambo yegazi kanye namasosha omzimba athinta umzimba. Sikhuthaza isiguli sethu ngasinye ngokukhuluma ngaso kubahlinzeki bezokwelapha abahlobene ngokusekelwe ekuhlaziyeni kwaso ngendlela efanele. Siyaqonda ukuthi imfundo iyindlela ejabulisayo uma ubuza abahlinzeki bethu imibuzo ngokwesicelo nokuqonda kwesiguli. UDkt. Jimenez, DC, usebenzisa lolu lwazi kuphela njengesevisi yezemfundo. Disclaimer
Ungabheka Kanjani I-Hypertension
UDkt. Alex Jimenez, DC, wethula: Ake sibuyele esihlahleni sesinqumo ukuze uqale ucabange ukuthi uzoyisebenzisa kanjani imodeli ye-go-to-it emithi esebenzayo ku-hypertension nokuthi uzoqala kanjani ukuhlola kangcono umuntu onomfutho wegazi ophezulu kunokuba umtshele ukuthi umfutho wegazi wakhe uphakeme. . Ingabe umzimba uthonywa ukuvuvukala, ukucindezeleka okwenziwe nge-oxidative, noma ukuphendula kwamasosha omzimba? Ingabe ithinta umsebenzi we-endothelial noma imisipha ebushelelezi ye-vascular kusukela kulezo zigaba ezintathu zokusabela, ukuvuvukala, ukucindezeleka okwenziwe nge-oxidative, noma ukuphendula komzimba? Ingabe sikhetha i-diuretic calcium channel blocker noma i-ACE inhibitor? Futhi ukuze wenze lokho, kubaluleke kakhulu esigabeni sethu sokuqoqa. Ukuthatha umlando wezokwelapha kanye nomugqa wesikhathi we-hypertension yabo, uthola umkhondo mayelana nokulimala kwesitho kuhlu lwemibuzo. Ubheka i-anthropometrics yabo.
Lokhu kuhlanganisa imibuzo elandelayo:
Yiziphi izimpawu zokuvuvukala? Ayini ama-biomarker kanye nezinkomba zomtholampilo?
Lezo zichazwe ngesihlahla sesinqumo somtholampilo. Futhi usuvele wenza lokho, uzonweba futhi ulungise kahle ilensi yakho kulokho ongakubona esigulini sakho somfutho wegazi ophezulu. Ake sengeze emugqeni wesikhathi iqala nini i-hypertension? Isikhathi se-hypertension siqala ngesikhathi sokukhulelwa. Kubalulekile ukubuza isiguli sakho ukuthi sisencane noma sineminyaka eminingi yokufunda. Ingabe unina wayecindezelekile? Ingabe bazalwa ngaphambi kwesikhathi noma ngaphambi kwesikhathi? Ingabe kwakukhona ukucindezeleka kokudla okunomsoco ekukhulelweni kwabo? Uma bekwazi lokho, ungaba nabantu ababili abanosayizi wezinso ezifanayo, kodwa lowo owayengenawo amaprotheni anele ngesikhathi ekhulelwe angaba ne-glomeruli engaphansi ngo-40%. Ukwazi lokho kuzoshintsha indlela oyilungisa ngayo imithi emashumini eminyaka kamuva uma wazi ukuthi kungenzeka ine-glomeruli engaphansi ngo-40%.
Umugqa Wesikhathi Womfutho Wegazi
UDkt. Alex Jimenez, DC, wethula: Ngakho-ke kubalulekile ukuthatha umugqa wesikhathi womfutho wegazi wabo. Bese kubalulekile futhi ukuqaphela ukuthi kwenzekani lapho siqala ukuhlela nokuqoqa idatha ngama-biomarker; ama-biomarker ayisisekelo azokunikeza izinkomba mayelana nokuthi anezinkinga nge-insulin lipids, noma ngabe anezinkinga ngokusebenza kabusha kwemithambo, ibhalansi yesistimu yezinzwa ezizimele, ukungalingani, ukuhlangana, noma imiphumela yobuthi bomzimba. Ngakho-ke lokhu kuyinto enengqondo ukuphrinta ngoba, esigulini sakho esinomfutho wegazi ophakeme, lokhu kungokwama-biomarker ongaqala ukuthola umkhondo wokuthi yiziphi izindawo zokungasebenzi kahle ezithinta ukuvuvukala, ingcindezi ye-oxidative, kanye nokusabela komzimba nokuthi lezi zimpawu ze-biomarker zibonisa kanjani lokho. ulwazi ngawe. Lokhu kunengqondo kakhulu ukuba phambi kwakho ukuze usize ukuguqula imicabango yakho mayelana nomfutho wegazi ophezulu futhi kukwenza ukwazi ukucwenga ezinye zezici zomuntu ongaphesheya kwe-stethoscope yakho ngendlela eqondene nawe, nenembe kakhudlwana.
Kodwa ake siqale ekuqaleni. Ingabe isiguli sakho sinomfutho wegazi ophezulu? Siyazi ukuthi kuye ngemiphumela yesitho sokugcina ye-commorbidities yabo, ungase wenze othile athole umfutho wegazi ophakeme kancane uma unenkinga enkulu ebuchosheni nasezinso noma enhliziyweni, kodwa kukhona imihlahlandlela ethile. Imihlahlandlela yethu yango-2017 ye-American Heart Association yezigaba zomfutho wegazi ibalwe lapha. Ziye zanda futhi zancipha emuva naphambili emashumini ambalwa eminyaka adlule, kodwa lokhu kucace kakhulu. Njengoba umfutho wegazi ukhuphukile, noma yini engaphezu kuka-120, yashintsha ngempela ukuthi bangaki abantu esiqala ukubabona noma esicabangela ukubhekana nezimbangela zomfutho wegazi wabo. Ngakho-ke sizobuyela kulokhu, ikakhulukazi odabeni lokusisiza ukuthi sibheke ukuthi sibahlukanisa kanjani abantu abanezinkinga zomfutho wegazi.
Indlela Yokukala Umfutho Wegazi
UDkt. Alex Jimenez, DC, wethula: Yisiphi isinyathelo sokuqala? Kuwukuthi uwuthatha kanjani umfutho wegazi esigulini sakho? Ingabe bayayiqapha ekhaya? Ingabe baletha lezo zinombolo kuwe? Uwuqapha kanjani umfutho wegazi emtholampilo wakho? Ukuthola kanjani ukufundwa okunembile emtholampilo wakho? Nazi izindlela zokukala umfutho wegazi ngokunembile kanye nemibuzo okufanele ucabangele ukuthi uyakwenza konke lokhu.
Uyasibuza isiguli sakho ukuthi sibe ne-caffeine ngehora eledlule? Kungakhathaliseki ukuthi babhemile ehoreni eledlule? Ingabe baye bachayeka ekubhemeni ngehora lokugcina? Ingabe indawo othatha kuyo umfutho wegazi ifudumele futhi ithulile? Ingabe bahlezi befulathele esihlalweni izinyawo zabo ziphansi? Ingabe usebenzisa ithebula eseceleni lokuzungeza ukuze uphumule ingalo yakho ezingeni lenhliziyo? Ingabe bahlezi etafuleni lezivivinyo izinyawo zabo zilenga, futhi umhlengikazi osizayo uphakamisa ingalo futhi afake i-axillary fold yabo ukuze babambe ingalo yabo lapho? Ingabe izinyawo zabo ziphansi? Bahlale lapho imizuzu emihlanu? Ingabe bazivocavoca emizuzwini engu-30 edlule?
Ungase ube nomfutho wegazi we-systolic uma yonke into isesimweni. Nansi inselele. Kunamamilimitha ayi-10 kuye kwayi-15 e-mercury ephakeme uma kuziwa ekuhlaleni nokuthatha umfutho wegazi. Kuthiwani ngosayizi we-cuff? Siyazi ekhulwini elidlule; abantu abadala abaningi babenomjikelezo wengalo ongaphezulu ongaphansi kwamasentimitha angama-33. Abantu abangaphezu kuka-61% manje sebenesiyingi sengalo engaphezulu esingaphezu kwamasentimitha angama-33. Ngakho-ke ubukhulu be-cuff buhlukile cishe ku-60% weziguli zakho zabantu abadala, kuye ngenani labantu bakho. Ngakho-ke kufanele usebenzise i-cuff enkulu. Ngakho bheka ukuthi umfutho wegazi uqoqwa kanjani ehhovisi lakho. Ake sithi umfutho wegazi uphakeme ezigulini zakho; khona-ke kufanele sibuze, ingabe kujwayelekile? Kuhle.
Izinhlobo Ezihlukene Ze-Hypertension
UDkt. Alex Jimenez, DC, wethula: Ingabe iphakeme ngenxa ye-white-coat hypertension? Ingabe banomfutho wegazi ovamile, okhuphukele ngaphandle kwasemtholampilo, noma umfutho wegazi ophakeme ofihlakele? Noma ingabe bane-hypertension eqhubekayo okuyinselelo? Sizokhuluma ngalokho. Ngakho-ke uma utolika, kubalulekile futhi ukuthi ucabangele ukuqapha kwe-blood pressure. Ngakho-ke uma unomuntu onomfutho wegazi ophakeme futhi ungazi noma umfutho wegazi uyehla futhi uzama ukuthola ukuthi ingabe une-hypertension eqhubekayo, ungasebenzisa ukuqapha komfutho wegazi wamahora angu-24. Isilinganiso segazi sasemini esingaphezu kuka-130 kuya ku-80 siwumfutho wegazi ophezulu kanti umfutho wegazi wasebusuku ongaphezu kuka-110 kuya ku-65 uwumfutho wegazi ophezulu. Pho kungani lokhu kubalulekile? Umfutho wegazi ojwayelekile wehla ufike cishe ku-15% ebusuku ngenxa yenkinga yokwehla komfutho wegazi. Ukwehluleka ukwehlisa umfutho wegazi ngesikhathi ulele ebusuku kungase kube nezinkinga ezingase zithinte umuntu usuku lonke.
Uma isiguli sakho silala ebusuku, kufanele sehle cishe ngo-15% lapho silele. Uma benomfutho wegazi ongadiphu, uhlotshaniswa nezifo ezihambisana nakho. Yiziphi ezinye zalezo zifo ezihambisana nomfutho wegazi ongawucwilisi? Ezinye zezimo ezihlotshaniswa nomfutho wegazi ongadiphuki zihlanganisa:
I-Congestive Heart Disease Izifo Zezinhliziyo Isifo se-Cerebrovascular Congestive Heart Ukwehluleka Ukwehluleka Okungapheli Kwesinso Ukuphulwa Kwe-Cerebral Ethule
Izifo Ezihlangene Ezihambisana Nomfutho Ongewona Wegazi
UDkt. Alex Jimenez, DC, wethula: Lezi yizifo ezihambisana nomfutho ongewona owegazi. Sonke siyavuma ukuthi umfutho wegazi ophakeme awulungile ngempela kuzo zonke lezo zimo. Ngakho-ke uma ubheka amaqembu abantu abahlukene noma ezinye izifo ezihambisanayo, umfutho wegazi ongaconsi uvame ukuhlotshaniswa nabantu abazwela i-sodium, abantu abanokwehluleka kwezinso, abantu abanesifo sikashukela, abantu abashiye i-hypertrophy ye-ventricular, abantu abane-hypertension ye-refractory. noma ukungasebenzi kahle kwesistimu yezinzwa futhi ekugcineni, i-apnea yokulala. Ngakho-ke, ukucindezelwa kwegazi okungagxili kwandisa ukuhlotshaniswa kwakho nokulimala kwenhliziyo engaphansi. Kulungile, ukuhlehlisa ukuhlehla kusho ukuthi unomfutho wegazi ophezulu ebusuku futhi ukukhuphuka okuhambisana kakhulu nasemini kuhlobene kakhulu nesifo sohlangothi esopha kakhulu. Futhi uma unomuntu onomfutho wegazi ophakeme wasebusuku, kufanele uqale ukucabanga ngezinto ezifana nemithambo ye-carotid kanye nokwanda kwe-carotid, ukushuba kwangaphakathi kwangaphakathi. Uqala ukucabanga nge-hypertrophy ye-ventricular yangakwesobunxele futhi ungayibona ku-EKG. Nakhu esikwaziyo nge-nocturnal hypertension. I-Nocturnal hypertension iwumfutho wegazi wasebusuku omkhulu kuno-120 ngaphezu kuka-70. Uhlotshaniswa nokubikezelwa okukhulu kokugula kwenhliziyo nemithambo yegazi kanye nokufa.
Uma unocturnal hypertension, kwandisa ingozi yokufa kwesifo senhliziyo ngama-29 kuya ku-38%. Kufanele sazi ukuthi kwenzekani ebusuku lapho silala, akunjalo? Awu, yikuphi okunye ukucwengwa? Okunye ukucolisiswa wukubona ukuthi ukuphumula komfutho wegazi kulawulwa uhlelo lwakho lwe-renin-angiotensin. Ukuvuka kwegazi kulawulwa isimiso sakho sezinzwa esinozwela. Ngakho-ke ake sikhulume ngokuthi uhlelo lwabo lwe-renal angiotensin luyiqhuba kanjani i-hypertension yabo yasebusuku, bese ucabanga ukuthi imuphi umuthi abawuphuzayo. Ungashintsha umthamo womuthi ube sebusuku. Nokho, ucwaningo luye lwabonisa ukuthi uma unomfutho wegazi ophakeme ebusuku futhi ungumuntu ongadiphuki, kungcono ukuthi uthathe ama-ACE inhibitors, ama-ARB, ama-calcium channel blockers, kanye nama-beta blocker athile ebusuku ngaphambi kokulala. Kodwa kunengqondo ukuthi ngeke uhambise ama-diuretics akho ebusuku, noma uzoba nokulala okuphazamisayo.
Ukubhekana Nomfutho Wegazi Wasemini Nobusuku
UDkt. Alex Jimenez, DC, wethula: Ngakho uma singabheki umfutho wegazi wasemini nasebusuku, kufanele sicabangele umphumela womthwalo wegazi. Iyini isilinganiso sakho somfutho wegazi wasemini kanye nomfutho wegazi olalayo ophakathi nendawo. Siyazi ukuthi umfutho wegazi kubantu abadala abasha unomfutho wegazi ophezulu cishe u-9% wesikhathi. Ngakho-ke okusho ukuthi umthwalo we-systolic cishe u-9% uma uqhathaniswa nabantu asebekhulile, cishe u-80% womthwalo wegazi yi-systolic. Futhi ngakho-ke uma unomthwalo ophezulu we-systolic, unezinkinga eziningi kanye nokulimala kwesitho sokugcina. Ngakho-ke esikhuluma ngakho ukusiza ukuhlonza isiguli sakho esinomfutho wegazi ophezulu; uthini umugqa wesikhathi wabo? Iyini i-phenotype yabo? Ingabe banomfutho wegazi ophakeme kuphela emini, noma banomfutho wegazi ophezulu nasebusuku? Kufanele sibheke ukuthi yini esiza ukulinganisa lokho.
Nali elinye iphuzu, cishe u-3.5% wabantu abanomfutho wegazi ophezulu abanesizathu sofuzo. Bangu-3.5% kuphela abantu izakhi zabo zofuzo ezibanga umfutho wegazi ophakeme. Amandla angaphansi kwe-matrix futhi uyawabona lawa maphethini, akunjalo? Ngakho ubheka ukuzivocavoca, ukulala, ukudla, ukucindezeleka, nobudlelwane. Ngakho siyazi ukuthi lezi zilinganiso ezine ezizimele zisiza ukunquma umfutho wegazi. Sizohlola uhlelo lwe-renal angiotensin, ivolumu ye-plasma lapho ibambelela khona oketshezini oluningi, umthamo wesibili kasawoti, kanye nokungasebenzi kahle kwe-endothelial. Ukungajwayelekile kunoma yikuphi kwalokhu kungaholela kumfutho wegazi ophakeme. Kade sikhuluma ngenye engaholela kumfutho wegazi ophakeme: isixhumanisi phakathi kokumelana ne-insulin nomfutho wegazi ophakeme.
Lokhu ngokomdwebo kukunikeza umbono wokusebenzelana kwe-physiologic phakathi kokumelana ne-insulin nomfutho wegazi ophakeme. Kuthinta ukukhula kwethoni yozwelo nokwandisa ibhalansi yesistimu ye-renal-angiotensin. Ngakho-ke masichithe imizuzu embalwa endleleni yesistimu ye-renin-angiotensin i-angiotensinogen yehle iye ku-angiotensin two. Sisebenzisa lawa ma-enzyme ngokunikeza ama-angiotensin-converting enzymes ezigulini zethu ezinomfutho wegazi ophakeme. Ukwenyuka kwe-angiotensin XNUMX kuholela ku-hypertrophy yenhliziyo, kuholela ekuncipheni kwesigaba esizwelayo, ukwanda kwevolumu yegazi, uketshezi lwe-sodium, ukugcinwa, nokukhululwa kwe-aldosterone. Ungakwazi yini ukubuza mayelana nama-biomarker akho esiguli? Ungabuza ukuthi banamazinga aphezulu e-renin?
Bheka Izimpawu
UDkt. Alex Jimenez, DC, wethula: Awu, ungakwazi. Ungahlola umsebenzi we-plasma renin namazinga e-aldosterone. Kubalulekile ukwenza lokhu uma isiguli sakho sinomfutho wegazi ophezulu futhi singakaze siphuze imithi ngoba yilapho i-nitrous oxide ibaluleke kakhulu khona. Yilapho i-endothelial nitric oxide synthase yakho ikhona. Lapha yilapho unengcindezi egcwele kanye ne-hemodynamic. Yilapho ukudla okudliwayo kwe-arginine noma indawo ezungezile ethinta i-nitric oxide kudlala indima enjalo empilweni yalolu ngqimba lwe-endothelia. Uma ukubeke ndawonye ngandlela thize, ngokuyisimangaliso, noma okungenani emehlweni akho engqondo, kuzovala izinkundla zethenisi eziyisithupha kumuntu omdala ojwayelekile. Kuyindawo enkulu. Futhi izinto ezibangela ukungasebenzi kahle kwe-endothelial akuzona izindaba ezintsha kubantu bezokwelapha ezisebenzayo. Ukwanda kwengcindezi ye-oxidative nokuvuvukala yizinto ezimbili esizishilo ezidlala umthelela.
Bese-ke, bheka ezinye zalezi ezinye izingxenye, i-ADMA yakho iphakanyisiwe futhi ihlotshaniswa nokungazweli kwe-insulin. Konke kuqala ukwakheka ndawonye ku-matrix exhumanayo. Ngakho-ke ubheka i-comorbidity eyodwa ku-cardiometabolic syndrome, futhi ithinta enye i-comorbidity. Ngokungazelelwe ubona ukuxhumana phakathi kwazo noma i-hyperhomocysteinemia, okuwuphawu lwekhabhoni eyodwa yemetabolism, okusho ukuthi ubheka ukwanela kwe-folate, i-b12, b6, i-riboflavin, kanye nalowo msebenzi we-carbon metabolism yakho. Ngakho-ke ake sibheke ezinye zalezi zimpawu zobungozi ezivelayo ukuze sithuthukise futhi silandelele iziguli ezinomfutho wegazi ophakeme. Ake sihlaziye kabusha i-ADMA futhi. I-ADMA imele i-asymmetric dimethyl arginine. I-asymmetric, i-dimethyl arginine iwuphawu lwe-biomarker yokungasebenzi kahle kwe-endothelial. Leyo molecule ivimbela i-nitric oxide synthase ngenkathi iphazamisa umsebenzi we-endothelial, futhi kuzo zonke i-comorbidities ehambisana nesifo se-cardiometabolic syndrome, i-ADMA ingaphakanyiswa.
Isiphetho
Ngakho-ke, njengesibuyekezo esisheshayo, i-L-arginine iguqulelwa ku-nitric oxide nge-nitric oxide synthase, futhi ukwanela kwe-nitric oxide kuholela ku-vasodilation. I-ADMA ivimbele lokhu kuguqulwa. Futhi uma amaleveli e-ADMA enyusiwe futhi namazinga e-nitric oxide ephansi, kusho ukuthi wehlile ukuhlanganisa kwe-nitric oxide platelet ekukhuphukeni kwe-LDL oxidation. Ngakho-ke izinto eziningi zinciphisa i-nitric oxide noma zihlotshaniswa namazinga aphansi e-nitric oxide, i-apnea yokulala, i-arginine yokudla ephansi, amaprotheni, ukuntuleka kwe-zinc, nokubhema.
Disclaimer
by UDkt Alex Jimenez I-Chiropractic , Umuthi Osebenzayo , Ukucindezeleka Oxidative , Ukucindezeleka
Isingeniso
Wonke umuntu usebenzelana naye ukucindezeleka ngesinye isikhathi empilweni yabo. Noma ngabe inhlolokhono yomsebenzi, umnqamulajuqu omkhulu, iphrojekthi, noma isivivinyo, ingcindezi ikhona ukugcina umzimba usebenza esimweni ngasinye umzimba odlula kuso. Ukucindezeleka kungasiza ukulawula umzimba izivikeli mzimba futhi usize i-metabolism ye-homeostasis njengoba umzimba ukwandisa amandla awo usuku lonke. Lapho sibhekene ukucindezeleka okungapheli kungabangela ukungasebenzi kahle kwe-metabolic emzimbeni njengokuphazamiseka kwamathumbu, ukuvuvukala, nokwenyuka kwamazinga eglucose egazini. Ukucindezeleka okungamahlalakhona kungase kuthinte isimo sengqondo nempilo yomuntu, imikhuba yokudla, kanye nezinga lokulala. Isihloko sanamuhla sizobheka ukuthi ukucindezeleka kuyinto enhle noma embi, ukuthi kuwuthinta kanjani umzimba, kanye nemiphumela yalokho okwenziwa ukucindezeleka okungapheli emzimbeni. Bhekisela iziguli kubahlinzeki abaqinisekisiwe, abanekhono abasebenza ngokukhethekile ekwelapheni amathumbu kubantu abaphethwe i-autonomic neuropathy. Siqondisa iziguli zethu ngokubhekisela kubahlinzeki bethu bezokwelapha abahlobene ngokusekelwe ekuhloleni kwabo uma kufaneleka. Sithola ukuthi imfundo ibalulekile ekubuzeni imibuzo enokuqonda kubahlinzeki bethu. UDkt. Alex Jimenez DC unikeza lolu lwazi njengensizakalo yezemfundo kuphela. Disclaimer
Ingabe umshwalense wami ungawukhokhela? Yebo, kungenzeka. Uma ungaqiniseki, nasi isixhumanisi esiya kubo bonke abahlinzeki bomshwalense esibakhava. Uma unemibuzo noma izinkathazo, sicela ushayele uDkt. Jimenez ku-915-850-0900
Ingabe Ukuba Nengcindezi Kuhle Noma Kubi?
Ingabe uzizwa ukhathazekile ngaso sonke isikhathi? Kuthiwani ngokuzwa ubuhlungu bekhanda obuhlala buwuhlupho? Ingabe uzizwa ukhungathekile futhi ulahlekelwa ukugxila noma ugqozi? Zonke lezi zimpawu ziyizimo ezicindezelayo umuntu abhekene nazo. Ucwaningo locwaningo luchazile ukucindezeleka noma i-cortisol njengehomoni yomzimba ehlinzeka ngemiphumela ehlukahlukene emisebenzini ehlukene ohlelweni ngalunye. I-Cortisol iyi-glucocorticoid eyinhloko evela ku-adrenal cortex. Ngesikhathi esifanayo, i-HPA (hypothalamus-pituitary-adrenal) axis isiza ukulawula ukukhiqizwa nokuphuma kwale hormone kuwo wonke umzimba. Manje i-cortisol ingaba yinzuzo futhi ibe yingozi emzimbeni, kuye ngesimo umuntu akuso. Ucwaningo olwengeziwe lubalulile ukuthi i-cortisol iqala futhi ithinte ubuchopho kanye nawo wonke umzimba njengoba ukucindezeleka ngesimo sawo esibucayi kungabangela umzimba ukuba uzivumelanise futhi uphile. Izimpendulo ezibukhali ezivela ku-cortisol zivumela ukusebenza kwe-neural, inhliziyo, i-immune, kanye ne-metabolic emzimbeni.
Kuyithinta Kanjani I-Metabolism Yomzimba?
Manje i-cortisol ithinta umzimba womzimba lapho ilawulwa ngomjikelezo wokulala opholile, ozinzile owehlisa i-corticotropin-releasing hormone (CRH) futhi ukhulise i-hormone yokukhula (GH). Ucwaningo locwaningo luye lwabonisa ukuthi lapho izindlala ze-adrenal zikhiqiza i-cortisol, iqala ukuba nokusebenzelana okuyinkimbinkimbi ne-hypothalamus kanye nezindlala ze-pituitary ohlelweni lwezinzwa kanye ne-endocrine. Lokhu kubangela ukuthi umsebenzi we-adrenal ne-thyroid emzimbeni uxhumeke eduze ngenkathi ungaphansi kokulawulwa kwe-hypothalamus namahomoni ashisayo. Indlala yegilo iqhudelana nezitho ze-adrenal nge-tyrosine. Ucwaningo locwaningo luthole ukuthi i-tyrosine isetshenziselwa ukukhiqiza i-cortisol ngaphansi kokucindezeleka ngenkathi ivimbela ukwehla komsebenzi wokuqonda okusabela ekucindezelekeni ngokomzimba. Kodwa-ke, lapho umzimba ungakwazi ukukhiqiza i-tyrosine eyanele, ingabangela i-hypothyroidism futhi ibangele ukuthi i-hormone ye-cortisol ibe yinto engapheli.
Uhlolojikelele Ngevidiyo Yokucindezeleka
VIDEO
Ingabe uke waphathwa yikhanda elibuhlungu elivele livele nje? Ingabe ulokhu ukhuluphala noma wehla ngesisindo? Ingabe uzizwa ukhathazekile noma ucindezelekile njalo ukuthi kuthinta ukulala kwakho? Lezi zonke izimpawu nezimpawu zamazinga akho e-cortisol aphenduka abe yisimo sawo esingamahlalakhona. Ividiyo engenhla ibonisa ukuthi ingcindezi yenzani emzimbeni wakho nokuthi ingabanga kanjani izimpawu ezingafuneki. Uma kukhona ukucindezeleka okungapheli emzimbeni, i-axis ye-HPA (neuro-endocrine) ayilingani ngenxa ye-activator-mediated activator ehilelekile ezifweni ze-autoimmune thyroid (AITD). Uma kukhona ukucindezeleka okungapheli emzimbeni, kungabangela ukukhiqizwa ngokweqile kwezinhlanganisela ezivuthayo emzimbeni kungenza i-IR. Izinto ezivuvukalayo zingalimaza noma zenze ama-insulin receptors asebenze okuholela ekwandeni kwe-insulin. Lokhu bese kuba nomthelela ekuqhekekeni kwesici esisodwa noma ngaphezulu esidingekayo ukuze kuphothulwe inqubo yokuthutha i-glucose emzimbeni.
Imiphumela YeCortisol Engapheli Emzimbeni
Uma kukhona ukucindezeleka okungapheli emzimbeni futhi kungazange kwelashwe noma kuncishiswe ngaso leso sikhathi, kungaholela entweni eyaziwa ngokuthi i-allostatic load. Umthwalo we-allostatic uchazwa njengokuguga nokudabuka komzimba nobuchopho ngenxa yokusebenza ngokweqile okungapheli noma ukungasebenzi kwezinhlelo zomzimba ngokuvamile ezibandakanyeka ezinseleleni zemvelo nokuzivumelanisa nezimo. Ucwaningo locwaningo luye lwabonisa ukuthi umthwalo we-allostatic ubangela ukukhiqizwa ngokweqile kwamahomoni afana ne-cortisol ne-catecholamine ukuphendula izingcindezi ezingapheli ezithinta umzimba. Lokhu kubangela ukuthi i-axis ye-HPA yenze enye yezinto ezimbili: ukusebenza ngokweqile noma ukuhluleka ukuvala ngemva kwezenzakalo ezicindezelayo ezibangela ukuphazamiseka kokulala. Ezinye izinkinga ezibangelwa ukucindezeleka okungapheli emzimbeni zingabandakanya:
Ukwanda kokukhiqizwa kwe-insulin kanye nokufakwa kwamafutha Ukushintsha ukusebenza kwamasosha omzimba I-Hypothyroidism (ukuphelelwa amandla kwe-adrenal) Ukugcinwa kwe-sodium namanzi Ukulahlekelwa ubuthongo be-REM Ukungaqini kahle ngokwengqondo nangokomzwelo Ukwanda kwezinto eziyingozi zenhliziyo nemithambo yegazi
Lezi zimpawu zibangela ukuthi umzimba ungasebenzi kahle, futhi ucwaningo luye lwabonisa ukuthi izingcindezi ezihlukahlukene zingalimaza umzimba. Lokhu kungenza kube nzima kakhulu ngomuntu ukubhekana nokucindezeleka futhi akunciphise.
Isiphetho
Sekukonke, ukucindezeleka noma i-cortisol iyi-hormone umzimba oyidingayo ukuze usebenze ngendlela efanele. Ukucindezeleka okungapheli emzimbeni okuvela ekucindezelekeni okuhlukahlukene kungabangela ukungasebenzi kahle kwe-metabolic njenge-hypothyroidism, ukuzuza isisindo, ukumelana ne-insulin, kanye nesifo se-metabolic, ukusho okumbalwa. Ingcindezi engapheli ingase futhi ibangele ukuphazamiseka kokulala njengoba i-axis ye-HPA ixhunywe phezulu futhi ingabonakala yehlisa umoya kancane. Lapho abantu beqala ukuthola izindlela zokubhekana nalezi zingcindezi ezihlukahlukene, banganciphisa amazinga abo okucindezeleka babuyele kokujwayelekile futhi bangabi nokucindezeleka.
Okubhekwayo
Jones, uCarol, noChristopher Gwenin. "I-Cortisol Level Dysregulation kanye Nokusabalala kwayo-Ingabe Iwashi Le-alamu Lemvelo?" Imibiko yePhysiological , John Wiley and Sons Inc., Jan. 2021, www.ncbi.nlm.nih.gov/pmc/articles/PMC7749606/ .
McEwen, Bruce S. "Imiphumela Emaphakathi Ye-Hormones Yokucindezeleka Empilweni Nezifo: Ukuqonda Imithelela Evikelayo Nelimazayo Yabalamuli Bengcindezi." Journal European of Pharmacology , I-US National Library of Medicine, 7 Apr. 2008, www.ncbi.nlm.nih.gov/pmc/articles/PMC2474765/ .
McEwen, Bruce S. "Ucindezelekile Noma Ucindezelekile: Uyini Umehluko?" Ijenali yePsychiatry & Neuroscience : JPN , I-US National Library of Medicine, Septhemba 2005, www.ncbi.nlm.nih.gov/pmc/articles/PMC1197275/ .
Rodriquez, Erik J, et al. "Umthwalo we-Allostatic: Ukubaluleka, Omaka, kanye Nokunqunywa Kwamaphuzu Kwabantu Abayingcosana Nokungafani." Ijenali Yezempilo Yasemadolobheni : I-Bulletin ye-New York Academy of Medicine , Springer US, Mashi. 2019, www.ncbi.nlm.nih.gov/pmc/articles/PMC6430278/ .
Thau, Lauren, et al. "Physiology, Cortisol - Statpearls - NCBI Bookshelf." Ku: StatPearls [I-inthanethi]. I-Treasure Island (FL) , StatPearls Publishing, 6 Sept. 2021, www.ncbi.nlm.nih.gov/books/NBK538239/ .
Omusha, u-Simon N. “L-Tyrosine Wokunciphisa Imiphumela Yengcindezi?” Ijenali yePsychiatry & Neuroscience : JPN , I-US National Library of Medicine, May 2007, www.ncbi.nlm.nih.gov/pmc/articles/PMC1863555/ .
Disclaimer
by UDkt Alex Jimenez I-Chiropractic , Ukucindezeleka Oxidative , I-Viscerosomatic Reflex , Ubuhle
Isingeniso
Njengoba umhlaba uhamba njalo, abantu abaningi kufanele bakhuthazele izimo ezicindezelayo ezithinta imizimba nempilo yabo. Umzimba udinga ama-hormone afanayo i-cortisol ukugcina ukusebenza njengoba kuthinta i amasosha omzimba, izinzwa, inhliziyo nemithambo yegazi kanye nesistimu ye-musculoskeletal , ukubala ezimbalwa. Omunye umsebenzi obalulekile umzimba owudingayo iglucose, edinga amandla ukuze uhlale ukunyakaza. Izimo ezidala ukuthi amazinga e-cortisol kanye namazinga eglucose anyuke emzimbeni angaholela ezindabeni ezingapheli ezifana nesifo sikashukela kanye nengcindezi engapheli. Lokhu kudala ukuthi umuntu aphatheke kabi futhi abe sesimweni esibucayi uma singalawulwa ngaso leso sikhathi. Isihloko sanamuhla sihlola ukuthi i-cortisol ne-glucose kuwuthinta kanjani umzimba kanye nokuxhumana okuxhumene phakathi kwengcindezi nesifo sikashukela. Thumela iziguli kubahlinzeki abaqinisekisiwe, abanekhono abasebenza ngokukhethekile ekulawuleni ingcindezi kanye nokwelashwa kwe-endocrine kubantu abanesifo sikashukela. Siqondisa iziguli zethu ngokubhekisela kubahlinzeki bethu bezokwelapha abahlobene ngokusekelwe ekuhloleni kwabo uma kufaneleka. Sithola ukuthi imfundo ibalulekile ekubuzeni imibuzo enokuqonda kubahlinzeki bethu. UDkt. Alex Jimenez DC unikeza lolu lwazi njengensizakalo yezemfundo kuphela. Disclaimer
Ingabe umshwalense wami ungawukhokhela? Yebo, kungenzeka. Uma ungaqiniseki, nasi isixhumanisi esiya kubo bonke abahlinzeki bomshwalense esibakhava. Uma unemibuzo noma ukukhathazeka, sicela ushayele uDkt. Jimenez ku-915-850-0900.
I-Cortisol Iwuthinta Kanjani Umzimba?
Ingabe ubulokhu uhlangabezana nezinkinga zokulala ebusuku? Kuthiwani ngekhanda elibuhlungu njalo elihlupha usuku lonke? Noma uke waqaphela ukwehla kwesisindo esiningi noma ukuzuza kwesisindo eduze kwe-midsection yakho? Ezinye zalezi zimpawu ziyizimpawu zokuthi amazinga e-cortisol ne-glucose aphezulu futhi angaphazamisa umzimba wakho. I-Cortisol iyi-hormone ekhiqizwa ohlelweni lwe-endocrine futhi ingaba yinzuzo noma ibe yingozi emzimbeni uma ingahlolisiswa njalo. Ucwaningo luye lwachaza i-cortisol njengenye yama-glucocorticoid avelele akhiqizwe ngenxa yokusabela kwamakhemikhali ezinto eziphilayo emzimbeni, ebonakala nge-HPA (hypothalamic-pituitary-adrenal) axis isiza izehlakalo zengqondo. Kodwa-ke, lapho amazinga e-cortisol ephenduka ehlala njalo emzimbeni ngenxa yezimo ezibangela ukuthi umzimba ungasebenzi, kungaba nomthelela omkhulu kumuntu futhi kubangele ukungalingani ku-axis ye-HPA. Ezinye zezimpawu eziholela e-cortisol engapheli emzimbeni zingabandakanya:
Ukungalingani kweHormonal Ukuphikiswa kwe-insulin Inzuzo yesisindo Ukwanda kwamafutha e-visceral "esisu". Ukwanda kokuphuma kwe-cortisol Izinkinga zamasosha omzimba
I-Allergies kanye Nesifuba Somoya Amalunga Avuvukele Ukungalulami kahle kokuzivocavoca
Ulwazi olwengeziwe lunikeziwe ukuthi ukuba khona kwe-cortisol emzimbeni kungasiza ukwandisa ukutholakala kweglucose egazini ebuchosheni. Nge-cortisol ehlinzeka ngokusebenza kwesitho, i-glucose yegazi ihlinzeka amandla omzimba.
Indlela I-Cortisol & Glucose Esebenza Ngayo Emzimbeni
I-Cortisol isiza ukugqugquzela ukuhlangana kweglucose esibindini, ivumele ukwakheka kwamaprotheni okuvimba ukuphusha ama-amino acid abe ushukela emzimbeni. Lokhu kwaziwa ngokuthi i-fatty acid liberation biotransformed ibe glucose. Uma lokhu kwenzeka, kusiza ukugqugquzela ukugcinwa kwamafutha e-visceral uma i-glucose eyeqile ingasetshenziswa, ngaleyo ndlela kubangele ukukhuluphala. Ucwaningo locwaningo luye lwabonisa ukuthi ukuntuleka kwe-cortisol kungabangela ukwehla kokukhiqizwa kwe-glucose esibindini emzimbeni. Lokhu kuzodala i-hypoglycemia, lapho umzimba ungenayo i-glucose eyanele ohlelweni lwawo. Ucwaningo olwengeziwe luyakhombisa ukuthi i-cortisol isabela kunoma yisiphi isicindezelo esithinta umuntu onamazinga aphansi eglucose kodwa futhi singaba sihle ngemva komthwalo weglucose. Ukuphatha amazinga eglucose ne-cortisol emzimbeni kungasiza ekuthuthukisweni kwesifo sikashukela.
I-Cortisol Ixhunyaniswa Kanjani Nohlobo 2 Lwesifo sikashukela- Ividiyo
VIDEO
Ingabe uke wabhekana nezimo ezicindezelayo ezenza imisipha yakho iqine? Kuthiwani ngokuzwa ushukela wakho wegazi ukhuphuka noma uphansi? Ingabe uzizwa imiphumela yokuvuvukala emzimbeni wakho wonke ebenza babe buhlungu? Ukucindezeleka kungabangela imiphumela eyingozi emzimbeni, kusebenze ukuvuvukala, ukwandisa ithoni yozwela, nokunciphisa ukuphendula kwe-glucocorticoid. Ukucindezeleka kungabuye kuxhunywe nesifo sikashukela, njengoba ividiyo engenhla ibonisa ukuthi i-hormone yokucindezeleka i-cortisol ihlotshaniswa kanjani nesifo sikashukela sohlobo 2. Ucwaningo locwaningo selushilo ukuthi i-cortisol ingahlotshaniswa kabi nemishini yokumelana ne-insulin, kwandise ukusebenza kwamaseli e-beta futhi kwandise i-insulin ekhishwa emzimbeni. Lokhu kungaba yingozi kubantu abaningi abanesifo sikashukela esivele sikhona futhi abebelokhu bebhekene nengcindezi.
Ukuxhumana Okuhlanganisiwe Phakathi Kwengcindezi nesifo sikashukela
Ukuxhumana okuxhumene phakathi kwengcindezi nesifo sikashukela kukhonjiswa ngokuthi izifundo zocwaningo zithole ukuthi i-pathophysiology yokukhathazeka nesifo sikashukela inyuse ubungozi bokumelana ne-insulin emzimbeni. Lapho umuntu ebhekene nengcindezi engapheli, kungadala ukuthi abe nezinkinga eziningi ezifana nalezi:
Ukungabekezelelani okubandayo Ukuncipha kokwazi kanye nemizwa Izinzwa zokudla Amandla aphansi usuku lonke
Uma lokhu kwenzeka, umzimba usengozini enkulu yokuthola ukumelana ne-insulin kanye nesifo sikashukela sohlobo 2. Ucwaningo locwaningo selushilo lolo hlobo lwesifo sikashukela lubonakala ngokumelana ne-insulin kanye nokungasebenzi kahle kwamaseli e-beta. I-glucocorticoid emzimbeni ingaba yingozi ngokweqile ukuze ithinte amaseli, ibangele ukungasebenzi kahle. Ucwaningo olwengeziwe lubonisiwe ukuthi noma yikuphi ukucindezeleka okucatshangwayo kungase kube isici esiyingozi esiyingozi esingagcini nje ngokuthinta umzimba, njenge-hypertension, i-BMI (inkomba yesisindo somzimba), noma ikhwalithi yokudla kodwa ingabangela ukukhuphuka kohlobo lwe-2 yesifo sikashukela. Lapho abantu bethola izindlela zokwehlisa ingcindezi engapheli, kungasiza ukulawula amazinga eglucose ukuthi afinyelele amazinga abucayi.
Isiphetho
Ukucindezeleka okungapheli komzimba kungabangela ukumelana ne-insulin futhi kubangele isifo sikashukela sibe khona ngaphambili. Umzimba udinga i-cortisol neglucose ukuze uqhubeke usebenza futhi ube namandla okunyakaza. Lapho abantu beqala ukuhlushwa ukucindezeleka okungapheli nesifo sikashukela, kungaba inselele ukuphatha; Nokho, ukwenza izinguquko ezincane emzimbeni njengokuthola izindlela zokwehlisa ingcindezi, ukudla ukudla okunempilo, nokuqapha amazinga eglucose kungasiza umzimba ukusetha kabusha amazinga eglucose ne-cortisol abe ngokwejwayelekile. Ukwenza lokhu kungakhulula abantu abaningi abafuna ukuqhubeka nohambo lwabo lwezempilo ngaphandle kokucindezeleka.
Okubhekwayo
Adam, Tanja C, et al. "I-Cortisol Ihlotshaniswa Kahle Nokuzwela Kwe-insulin Entsha Ye-Latino Ekhuluphele ngokweqile." I-Journal ye-Clinical Endocrinology kanye ne-Metabolism , I-Endocrine Society, Oct. 2010, www.ncbi.nlm.nih.gov/pmc/articles/PMC3050109/ .
De Feo, P, et al. "Umnikelo we-Cortisol ku-Glucose Counterregulation Ebantwini." I-American Journal of Physiology , I-US National Library of Medicine, ngoJulayi 1989, pubmed.ncbi.nlm.nih.gov/2665516/ .
Hucklebridge, FH, et al. "I-Awakening Cortisol Response and Blood Glucose Levels." I-Life Sciences , US National Library of Medicine, 1999, pubmed.ncbi.nlm.nih.gov/10201642/ .
Joseph, Joshua J, kanye noSherita H Golden. "I-Cortisol Dysregulation: I-Bidirectional Link phakathi kweStress, Depression, kanye Nohlobo 2 Lwesifo sikashukela." Izimemezelo zeNew York Academy of Science , I-US National Library of Medicine, Mashi. 2017, www.ncbi.nlm.nih.gov/pmc/articles/PMC5334212/ .
Kamba, Aya, et al. "Ukuhlangana phakathi Kwamazinga e-Cortisol eSerum Ephakeme kanye Nokuncipha Kwemfihlo Ye-insulin Kubantu Abajwayelekile." PloS One , Umtapowolwazi Womphakathi Wesayensi, 18 Nov. 2016, www.ncbi.nlm.nih.gov/pmc/articles/PMC5115704/ .
Lee, Do Yup, et al. "Izici Zobuchwepheshe Nezomtholampilo ze-Cortisol Njengomaka Wamakhemikhali Ezinto Eziphilayo Zokucindezeleka Okungapheli." Imibiko ye-BMB , Korean Society for Biochemistry and Molecular Biology, Apr. 2015, www.ncbi.nlm.nih.gov/pmc/articles/PMC4436856/ .
Thau, Lauren, et al. "Physiology, Cortisol." Ku: StatPearls [I-inthanethi]. I-Treasure Island (FL) , StatPearls Publishing, 6 Sept. 2021, www.ncbi.nlm.nih.gov/books/NBK538239 .
Disclaimer
by UDkt Alex Jimenez I-Chiropractic , Ubuhlungu obungapheliyo , I-Foot Orthotics , Impilo , Ukunakekelwa kokulimala , Inhlekelele Yokulimala , Ukucindezeleka Oxidative , Izixazululo , Ukwelashwa , Ubuhle
Umzimba ungumshini osebenza kahle okwazi ukubekezelela noma yini ephonswa endleleni yawo. Kodwa-ke, lapho ithola ukulimala, inqubo yokwelapha yemvelo yomzimba izoqinisekisa ukuthi umzimba ungabuyela emisebenzini yawo yansuku zonke. Inqubo yokuphola komsipha elimele iyahlukahluka kuwo wonke umzimba. Kuye ngokuthi umonakalo mkhulu kangakanani nokuthi inqubo yokuphulukisa izothatha isikhathi esingakanani, umzimba ungalulama ezinsukwini ezimbalwa kuya ezinyangeni ezimbalwa. Enye yezinqubo zokuphulukisa ezinonya kakhulu umzimba okufanele uzibekezelele ukuphuka kwe-calcaneal tendon.
I-Calcaneal Tendon
Ithenda ye-calcaneal noma i-Achilles tendon iyithenda ewugqinsi etholakala ngemuva komlenze. Le-muscle-tendon yiyo eyenza umzimba unyakaze ngenkathi uhamba, ugijima, noma ugxuma. Akukhona lokho kuphela, i-tendon ye-calcaneal iyi-tendon enamandla kunazo zonke emzimbeni, futhi ixhuma i-gastrocnemius nemisipha ye-soleus ethanjeni lesithende. Lapho i-tendon ye-calcaneal iqhuma, inqubo yokuphulukisa ingahlala kusukela emasontweni kuya ezinyangeni kuze kube yilapho ilulama ngokugcwele.
Imiphumela Yokuphulukisa Yokwelashwa Nge-Laser Ephansi
Enye yezindlela ezingasiza inqubo yokuphulukisa imisipha ye-calcaneal ukwelapha nge-laser okuphansi. Izifundo zibonisiwe ukuthi ukwelashwa kwe-laser okuphansi kungasheshisa ukulungiswa kwe-tendon eyonakele ngemva kwesilonda esiyingxenye. Akugcini lapho kodwa nekama Ukwenziwa kwe-ultrasound kanye nokwelashwa nge-laser ephansi kuye kwacwaningwa ukuze kube ama-agent aphathekayo ekwelapheni ukulimala kwe-tendon. Izifundo zabonisa ukuthi inhlanganisela yokwelapha nge-laser ephansi kanye ne-ultrasound inezici ezizuzisayo phakathi nenqubo yokutakula yokwelapha ukulimala kwe-calcaneal tendon.
Ucwaningo lutholakele ukuthi lapho iziguli zelashelwa imisipha yazo ye-calcaneal, amazinga azo e-hydroxyproline endaweni eselashwayo anda kakhulu nge-ultrasound kanye ne-laser t ephansi.ukwelapha. Izakhiwo zomzimba zemvelo ze-biochemical kanye ne-biomechanical ku-tendon elimele ziyakhula, ngaleyo ndlela zithinte inqubo yokuphulukisa. Olunye ucwaningo luye lwabonisa ukuthi ukwelashwa kwe-laser okuphansi kungasiza ekunciphiseni i-fibrosis nokuvimbela ukucindezeleka okwenziwe nge-oxidative ku-tendon ye-calcaneal ehlukumezekile. Ucwaningo lwaze lwabonisa ukuthi ngemva kokuba i-tendon ye-calcaneal ihlukumezekile, ukuvuvukala, i-angiogenesis, i-vasodilation, kanye ne-matrix ye-extracellular kwakhiwa endaweni ethintekile. Ngakho-ke lapho iziguli zelashwa ngokwelashwa nge-laser okuphansi cishe izinsuku eziyishumi nane kuya kwezingamashumi amabili nanye, ukungajwayelekile kwazo kwe-histological kuyehla, kunciphisa ukugxila kwe-collagen kanye ne-fibrosis; ukuvimbela ukucindezeleka kwe-oxidative ekukhuleni emzimbeni.
Isiphetho
Sekukonke, kuthiwa imiphumela yokwelashwa kwe-laser ephansi ingasiza ukusheshisa inqubo yokuphulukisa yokulungisa i-tendon ye-calcaneal. Imiphumela ethembisayo iye yafakazelwa njengoba ukwelapha nge-laser ephansi kungasiza ukulungisa ithenda eyonakele, ukunciphisa ukucindezeleka kwe-oxidative nokuvimbela i-fibrosis ekukhuphukeni, okubangela izinkinga eziningi ku-tendon elimele. Futhi ngokuhlanganiswa kwe-ultrasound, i-calcaneal tendon ingalulama ngokushesha ukuze umzimba uqhubeke nemisebenzi yawo yansuku zonke ngaphandle kokulimala isikhathi eside.
References:
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Fillipin, Lidiane Isabel, et al. "I-Low-Level Laser Therapy (LLLT) Ivimbela Ukuxineka Kwe-Oxidative Futhi Yehlisa I-Fibrosis ku-Rat Traumatised Achilles Tendon." Ama-Lasers Ekuhlinzeni Nezokwelapha , I-US National Library of Medicine, Oct. 2005, pubmed.ncbi.nlm.nih.gov/16196040/ .
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