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Ukuzila

Emuva Clinic Fasting Functional Medicine Team. Ukuzila ukudla wukuzithiba noma ukuncishiswa kokunye noma konke ukudla, iziphuzo, noma kokubili isikhathi esithile.

Ukuzila ukudla okuphelele noma okusheshayo ngokuvamile kuchazwa njengokuzithiba kukho konke ukudla noketshezi ngesikhathi esithile esicacisiwe.
Kungadliwa itiye nekhofi elimnyama.
Ukuzila amanzi kusho ukuzithiba kukho konke ukudla neziphuzo ngaphandle kwamanzi.
Ukuzila ukudla kungaba ngezikhathi ezithile noma kube nemingcele ngokwengxenye, kukhawulele izinto noma ukudla okuthile.
Ngomongo wokuphila, kungabhekisela esimweni somuntu ongadlile noma isimo se-Metabolic.
Izinguquko ze-metabolic zenzeka ngesikhathi sokuzila.

Isib: umuntu kukholakala ukuthi uzilile ngemva kwamahora angu-8-12 esephelile kusukela ekudleni kwakhe okokugcina.

Izinguquko ze-metabolic ezivela esimweni esisheshayo ziqala ngemuva kokumuncwa ukudla, imvamisa amahora angama-3-5 ngemuva kokudla.

Izinzuzo zezempilo:

Ikhuthaza Ukulawulwa Koshukela Wegazi
Ulwa nokuvuvukala
Ithuthukisa Impilo Yenhliziyo
Ama-Triglycerides
Amazinga e-Cholesterol
Ivimbela I-Neurodegenerative Disorders
Yandisa Ukukhiqizwa KweHormone Yokukhula
umzimba
Weight Loss
Amandla Emisipha

Izinhlobo zokuzila ukudla:

Ukushesha kokuxilonga kusho kusuka emahoreni angama-8-72 (kuya ngeminyaka yobudala) okwenziwa ngaphansi kokubhekwa ukuze kube lula uphenyo lwezinkinga zempilo, njenge-hypoglycemia.
Izinhlobo eziningi zokuzila zenziwa emahoreni angama-24 kuye kwangama-72
Izinzuzo zezempilo zandisa ukuncipha kwesisindo
Ukusebenza kobuchopho okungcono.
Abantu bangase futhi bazile ukudla njengengxenye yenqubo yezokwelapha noma ukuhlolwa, okufana ne-colonoscopy noma ukuhlinzwa.
Ekugcineni, kungaba yingxenye yesiko.

Ukuhlolwa kokuxilonga kuyatholakala ukuze kutholwe isimo esisheshayo.

Ukuzila Ukuzila Kuyithinta Kanjani Impilo Yokugaya Ku-Functional Neurology

by UDkt Alex Jimenez | Ukuzila, Umuthi Osebenzayo, I-Gastro Intestinal Health, Amathumbu kanye Nempilo Yamathumbu, Impilo, Imvelo yemvelo, Nutrition, Ubuhle

Ucwaningo oluningana lubonise ukuthi ukudla i-fiber eyanele nokudla okwandisa inani lamagciwane epheshaneni lesisu (GI) kuhlotshaniswa nokuzwela kwe-insulin okuthuthukisiwe kanye nokunciphisa ukusabela komzimba nokuvuvukala, phakathi kwezinye izinzuzo eziningi zezempilo. Lezi zifundo ezifanayo ziphinde zabonisa ukuthi ukuzila ukudla kungaba nalezi zinzuzo zezempilo ezifanayo. Izinhlobo ezahlukene zokuzila zingasetshenziswa njengendlela yokwelapha yezinkinga ezihlukahlukene zezempilo zokugaya ukudla. Eqinisweni, ezinye izifundo zibonise ukuthi ukuzila ukudla kungasiza ekuthuthukiseni izinkinga zempilo yokugaya njenge-SIBO, i-IBS, kanye namathumbu avuzayo. �

Ukuhlolwa kokuzila ukudla kanye nempilo yokugaya ukudla

UMike Hoaglin, owayengumqondisi wemitholampilo wombukiso kaDkt Oz kanye nohola phambili womtholampilo we-uBiome, inkampani ye-biotechnology esiza ochwepheshe bezempilo neziguli ukuthi baqonde ukuthi i-gut microbiome iyithinta kanjani impilo nokuphila kahle, ubonise ukubaluleka kwamagciwane emathunjini ethu (GI). ) ipheshana ngokwabelana ngezilinganiso zomphumela wocwaningo azizame yena ngokwakhe. Izinkampani ze-Biotechnology ezifana ne-uBiome zinganquma iphrofayili yesiguli ye-probiotic, okuhlanganisa ama-microorganisms "anempilo" kanye ne-pathogenic angase ahlotshaniswe nezinkinga zempilo yokugaya njenge-Crohn's nesifo sokulonda kwe-ulcerative. �

Ngemva kokufunda ukuthi ukuzila ukudla kungasiza kanjani ekuthuthukiseni isimiso somzimba sokuzivikela ezifweni, kusebenze ama-stem cells, futhi kunciphise ingozi yokuba nezinhlobo eziningi zomdlavuza, uMike washukumiseleka ukuba azenzele owakhe amanzi ngokushesha izinsuku ezinhlanu ukuze abone ukuthi le ndlela yamasu yokudla izowathinta kanjani amathumbu akhe. i-microbiome. Uphinde wagqugquzelwa ukwazi ukuthi ukuzila ukudla kungawathinta kanjani amazinga akhe amandla kanye nokuhlakazeka kwengqondo kanye nenkungu yobuchopho. Ngokuthumela isampula yesihlalo, wanquma i-spectrum yamagciwane epheshaneni lakhe lesisu (GI) ngaphambi kokuqala inqubo yokuzila. UMike Hoaglin ubengaphansi kokuqondisa kukadokotela wakhe osebenzayo. �

Ukuqonda Imiphumela Yokuzila

Ngokusho kwemiphumela yakhe yokuhlolwa kwephrofayili ye-uBiome probiotic, uMike wayene-dysbiosis, ukungalingani ekubunjweni kwe-gut microbiome ehambisana nokuncipha kwezinhlobonhlobo zezinto eziphilayo zamabhaktheriya "anempilo" kanye nokwanda kwamagciwane "ayingozi" aziwa ngokubangela ukuvuvukala. UMike Hoaglin uhlele izinsuku ezinhlanu ohlelweni lwakhe ukuze aqale inqubo yokuzila ukudla ngemuva kokukhuluma nodokotela wakhe osebenzayo. Njengoba abantu abaningi beye bachaza phakathi nezinsuku ezimbalwa zokuqala zokuzila ukudla, uMike waba nesikhathi esinzima kakhulu sokungadli ukudla. Wachaza ukuthi uzizwa edidekile futhi elambile, nokho, wayekwazi nokulala. �

Ukulamba kukaMike kwase kudambile ngokubonga ngosuku lwesithathu lwenqubo yokuzila futhi, nakuba wayesenezinsuku ezimbalwa ezisele zendlela yokwelashwa, waqonda ukuthi yonke inqubo yokuzila yayingeke ibe yinselele njengoba yayinjalo okokuqala. izinsuku ezimbili, naphezu kokuba ushukela wegazi lakhe, noma ushukela, uphansi. UMike Hoaglin wezwa ukwanda kumazinga akhe wamandla ngosuku lwesine lwenqubo yokuzila ukudla. Wazizwa ecace ngokwengeziwe ngokwengqondo njengoba isimiso sakhe sokugaya siqala ukusebenzisa amafutha njengamandla esikhundleni sokusebenzisa ushukela, noma i-glucose. Ngokushesha waqaphela ukuthi ama-stem cells akhe asebenze phakathi nosuku lwesine lwenqubo yokuzila ukudla. �

UMike waqeda inqubo yokuzila ukudla ngosuku lwesihlanu ngo-5:00 ntambama ngokudla inkomishi yomhluzi wamathambo. I-Bone broth ingenye yezinhlobo zokudla ezinconyiwe kakhulu ukusiza abantu ukuthi baguquke ekuzileni ngoba unama-amino acid abalulekile, njenge-glutamine ne-glycine, ahlinzeka ngokudla okunomsoco epheshaneni lesisu (GI) ngokushesha nje lapho eqala ukugaya ukudla futhi. Ngaphezu kwalokho, ukwengeza usawoti we-Himalayan emhluzini wakho wethambo kunganikeza amaseli akho amaminerali angeziwe. UMike waqhubeka nokuguquka ekuzileni ukudla ngokudla ukudla kwezitshalo okunothe nge-fiber, amafutha anempilo, nenani elincane lamaprotheni anomzimba omncane, ezinhlobonhlobo ezigayeka kalula. �

UMike Hoaglin uhlole i-microbiome yakhe yamathumbu kulandela inqubo yakhe yokuzila ukudla futhi wamangala ngezinyathelo zemiphumela yephrofayili yakhe ye-probiotic. Ngokokuhlolwa kwe-uBiome, ukuzila ukudla “kusethe kabusha” i-Mike's gut microbiome, noma amagciwane epheshaneni lesisu (GI). Imiphumela yabonisa ukwakheka okunokulinganisela kwe-gut microbiome yakhe futhi wandise ukuhlukahluka kwebhaktheriya "enempilo" futhi wehlisa amagciwane "ayingozi". Ngemva kokuphothula ucwaningo lwakhe, uMike Hoaglin waqaphela kakhudlwana ukuthi uhlobo lokudla esikudlayo lungagcina luyithinte kanjani impilo yethu yokugaya ukudla. �

Ukuzila ukudla kuyindlela eyaziwayo, enamasu yokudla engaba nezinhlobonhlobo zezinzuzo zezempilo zokugaya ukudla kubantu abaningi. Abantu abaningi bangazuza kakhulu ngokuzila ukudla. Ukuzila ukudla kungenza kusebenze i-autophagy, noma inqubo yemvelo yokukhipha ubuthi emzimbeni, ukusiza ukushanela amagciwane amaningi kanye nemfucumfucu yokudla engagayekile ukuze kuqedwe njengemfucuza, kuphinde kusebenze izinqubo zokulwa nokuvuvukala ukuze kuncishiswe ukuvuvukala kanye nengcindezi ye-oxidative. Ngesikhathi sokuhlolwa, ukuzila ukudla kuboniswe kunezinzuzo ezinkulu empilweni yokugaya ukudla. Nokho, kubalulekile ukukhumbula ukuthi ukuzila kungase kungabi okwawo wonke umuntu. Qiniseka ukuthi ukhuluma nodokotela oqeqeshiwe nonolwazi ngaphambi kokuzama noma yiziphi izindlela zokuzila ukudla. - UDkt Alex Jimenez DC, CCST Insight

Ifomu Lokuhlola I-Neurotransmitter

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I-Neurotransmitter Assessment Form elandelayo ingagcwaliswa futhi yethulwe kuDkt Alex Jimenez. Izimpawu ezilandelayo ezisohlwini lwaleli fomu akuhloselwe ukuthi zisetshenziswe njengokuxilongwa kwanoma yiluphi uhlobo lwesifo, isimo, nanoma yiluphi olunye uhlobo lwenkinga yezempilo. �

Impilo yethu yokugaya incike ekwakhekeni kwe-gut microbiome yethu enempilo noma amagciwane epheshaneni lethu lesisu (GI). Le phrofayili ye-probiotic idlala indima ebalulekile kumasosha omzimba wethu futhi lokhu kungathinta impendulo yethu yokuvuvukala. Futhi, ukudla esikudlayo, amahomoni, ama-neurotransmitters, ngisho nesimo sethu se-adrenal ne-mitochondrial singathonya impilo yethu yokugaya. Amagciwane angajwayelekile noma amaningi angabangela izinkinga eziningi zempilo yokugaya ukudla. Abacwaningi kanye nabasebenzi bezempilo bathole ukuthi "ukuzila ukudla" kungasiza ukukhuthaza i-microbiome yamathumbu enempilo futhi kusekele impilo yonke yokugaya. � Ucwaningo oluningana lubonise ukuthi ukudla i-fibre eyanele nokudla okwandisa inani lamagciwane epheshaneni lesisu (GI) kuhlotshaniswa nokuzwela kwe-insulin okuthuthukisiwe kanye nokuncipha kokusabela komzimba nokuvuvukala, phakathi kwezinye izinzuzo eziningi zezempilo. Lezi zifundo ezifanayo ziphinde zabonisa ukuthi ukuzila ukudla kungaba nalezi zinzuzo zezempilo ezifanayo. Izinhlobo ezahlukene zokuzila zingasetshenziswa njengendlela yokwelapha yezinkinga ezihlukahlukene zezempilo zokugaya ukudla. Eqinisweni, ezinye izifundo zibonise ukuthi ukuzila ukudla kungasiza ekuthuthukiseni izinkinga zempilo yokugaya njenge-SIBO, IBS, kanye namathumbu avuzayo. �

Ububanzi bolwazi lwethu bukhawulelwe ezindabeni ze-chiropractic, musculoskeletal, kanye nezinzwa noma izindatshana zemithi esebenzayo, izihloko, nezingxoxo. Sisebenzisa izivumelwano zezempilo ezisebenzayo ukwelapha ukulimala noma ukuphazamiseka kwesistimu ye-musculoskeletal. Ihhovisi lethu lenze umzamo ophusile wokuhlinzeka ngezingcaphuno ezisekelayo futhi likhombe ucwaningo olufanele noma izifundo ezisekela okuthunyelwe kwethu. Senza futhi amakhophi ocwaningo olusekelayo atholakale ebhodini noma emphakathini uma uwacela. Ukuze uqhubeke uxoxa ngesihloko esingenhla, sicela ukhululeke ukubuza uDkt. Alex Jimenez noma usithinte ku 915-850-0900.�

Kukhethwe nguDkt. Alex Jimenez �

References:

�Umthelela Wokuzila Ukudla Kwi-Microbiome Yakho.� Naomi Whittel, 12 Mar. 2019, www.naomiwhittel.com/the-impact-of-fasting-on-your-microbiome/.

Ingxoxo Yesihloko Eyengeziwe: Ubuhlungu Obungamahlalakhona

Ubuhlungu obungazelelwe yimpendulo yemvelo yesimiso sezinzwa esiza ukukhombisa ukulimala okungenzeka. Njengesibonelo, izimpawu zobuhlungu zihamba zisuka endaweni elimele zidlule ezinzwaneni nomgogodla ziye ebuchosheni. Ubuhlungu ngokuvamile abubi kakhulu njengoba ukulimala kuphulukisa, noma kunjalo, ubuhlungu obungapheli buhlukile kunohlobo olujwayelekile lobuhlungu. Ngobuhlungu obungapheli, umzimba womuntu uzoqhubeka nokuthumela izimpawu zobuhlungu ebuchosheni, kungakhathaliseki ukuthi ukulimala sekupholile. Ubuhlungu obungapheli bungathatha amasonto ambalwa kuya ngisho neminyaka eminingana. Ubuhlungu obungapheli bungathinta kakhulu ukuhamba kwesiguli futhi bunganciphisa ukuguquguquka, amandla, nokukhuthazela. �

I-Neural Zoomer Plus Yezifo Zezinzwa

UDkt Alex Jimenez usebenzisa uchungechunge lokuhlola ukusiza ukuhlola izifo zezinzwa. I-Neural Zoomer^TM I-Plus iwuxha lwama-autoantibodies emizwa olunikeza ukuqashelwa okukhethekile kwe-antibody-to-antigen. I-Vibrant Neural Zoomer^TM I-Plus yakhelwe ukuhlola ukusebenza kabusha komuntu kuma-antigens we-neurological angama-48 axhumene nezifo ezahlukahlukene ezihlobene nemizwa. I-Vibrant Neural Zoomer^TM I-Plus ihlose ukunciphisa izimo zemizwa ngokunika amandla iziguli nodokotela ngesisetshenziswa esibalulekile sokutholwa kwengozi kusenesikhathi kanye nokugxila okuthuthukisiwe ekuvimbeleni okuyinhloko komuntu siqu. �

Ukuzwela Kokudla kwe-IgG & IgA Immune Response

UDkt. Alex Jimenez usebenzisa uchungechunge lokuhlola ukusiza ukuhlola izinkinga zezempilo ezihlobene nokuzwela ukudla. I-Zoomer Yokuzwela Ukudla^TM iwuxhaxha lwama-antigen okudla angu-180 avame ukusetshenziswa anikeza ukunakwa okukhethekile kwe-antibody-to-antigen. Leli phaneli likala ukuzwela kwe-IgG ne-IgA yomuntu kuma-antigen okudla. Ukwazi ukuhlola amasosha omzimba e-IgA kunikeza ulwazi olwengeziwe ekudleni okungenzeka kubangele ukulimala kolwelwesi lwamafinyila. Ukwengeza, lokhu kuhlolwa kulungele iziguli okungenzeka ukuthi zihlushwa ukusabela okubambezelekile ekudleni okuthile. Ukusebenzisa ukuhlolwa kokuzwela kokudla okusekelwe kumasosha omzimba kungasiza ukubeka phambili ukudla okudingekile ukuze kuqedwe nokudala uhlelo lokudla olungokwezifiso oluzungeze izidingo ezithile zesiguli. �

I-Gut Zoomer Yokukhula Kwamagciwane Amathumbu Amancane (SIBO)

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UDkt. Alex Jimenez usebenzisa uchungechunge lokuhlola ukusiza ukuhlola impilo yamathumbu ehambisana nokukhula kwebhaktheriya emathunjini amancane (SIBO). I-Vibrant Gut Zoomer^TM inikeza umbiko ohlanganisa izincomo zokudla kanye nezinye izithasiselo zemvelo ezifana nama-prebiotics, ama-probiotics, nama-polyphenols. I-gut microbiome itholakala kakhulu emathunjini amakhulu futhi inezinhlobo ezingaphezu kwe-1000 zamabhaktheriya adlala indima ebalulekile emzimbeni womuntu, kusukela ekubumbeni amasosha omzimba kanye nokuba nomthelela kumetabolism yezakhi kuya ekuqiniseni umgoqo wamathumbu emathunjini (i-gut-barrier). ). Kubalulekile ukuqonda ukuthi inani lamabhaktheriya ahlala ngendlela ye-symbiotically epheshaneni lesisu somuntu (GI) liyithinta kanjani impilo yamathumbu ngoba ukungalingani ku-gut microbiome ekugcineni kungaholela ezimpawu zepheshana lesisu (GI), izimo zesikhumba, ukuphazamiseka kwe-autoimmune, ukungalingani kwamasosha omzimba. , kanye nezifo eziningi zokuvuvukala. �

Amafomula Okwesekwa kwe-Methylation

I-XYMOGEN I-Exclusive Professional Formulas iyatholakala ngochwepheshe bokunakekelwa kwezempilo abakhethiwe abanelayisensi. Ukuthengiswa kwe-inthanethi kanye nesaphulelo kwamafomula e-XYMOGEN kunqatshelwe ngokuphelele.

Ngokuziqhenya,�UDkt Alexander Jimenez yenza amafomula e-XYMOGEN atholakale ezigulini ezingaphansi kwethu kuphela.

Sicela ushayele ihhovisi lethu ukuze sinikeze ukubonisana nodokotela ukuze sifinyelele ngokushesha.

Uma uyisiguli se I-Injury Medical & Chiropractic�Umtholampilo, ungase ubuze mayelana ne-XYMOGEN ngokushaya ucingo 915-850-0900.

Ukuze kube lula kuwe futhi ubuyekeze i- XYMOGEN imikhiqizo sicela ubuyekeze isixhumanisi esilandelayo. *XYMOGEN-Ikhathalogi-Thwebula �

* Zonke izinqubomgomo ze-XYMOGEN ezingenhla zisasebenza ngokuqinile. �

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I-Functional Neurology: Ukuzila ukudla kanye ne-Autophagy yempilo yokugaya ukudla

by UDkt Alex Jimenez | Ukuzila, Umuthi Osebenzayo, I-Gastro Intestinal Health, Amathumbu kanye Nempilo Yamathumbu, Impilo, Imvelo yemvelo, Nutrition, Ubuhle

Ososayensi nabasebenzi bezempilo sebeqala ukukhanya ngokubaluleka kokwakheka kwe-gut microbiome yethu, noma inani labantu bamagciwane “anempilo” epheshaneni lethu lesisu (GI). Ngokocwaningo locwaningo, inani elingavamile noma eleqile lamagciwane amathumbu lingaba esinye sezimbangela ezivame kakhulu zezinkinga zempilo ezahlukahlukene zokugaya ukudla, okuhlanganisa i-SIBO ne-IBS. Okhokho bethu bafake ukudla okuvutshelwe njengeyogathi, i-kimchi, ne-sauerkraut njengengxenye ebalulekile yokudla kwabo kwendabuko ukuze balawule futhi balawule ukwakheka kwamagciwane abo “anempilo”: i-gut microbiome. �

Ukuthola izindlela zokuthuthukisa ngokwemvelo impilo yethu yokugaya ngokugcina iphrofayili "enempilo" ye-probiotic kuye kwaba isihloko esithandwayo ezizukulwaneni eziningi. Ngenxa yalokho, ukudla ukudla okuvutshelwe njengalokhu okubalwe ngenhla, okuhlanganisa namanye amaqembu okudla anama-probiotics engeziwe, kanye nokuthatha izithasiselo ze-probiotic kuye kwanda kakhulu ekudumeni eminyakeni yamuva nje. Enye indlela yokuthuthukisa ngokwemvelo impilo yokugaya ukudla esanda kuthandwa kakhulu ukuzila ukudla, ukuzithiba ngamasu noma ukunciphisa ukudla okuningana noma konke isikhathi esithile. Ukuzila ukudla ekugcineni kungasiza ekuthuthukiseni impilo yonke yokugaya ukudla. �

Ukuzila ukudla kungasiza ukusekela ukwakheka okunempilo kwe-gut microbiome yethu futhi kungasetshenziswa njengendlela yokwelapha izimo nezifo ezihlukahlukene, ezifana nobuhlungu bekhanda, i-migraines, i-eczema, i-metabolic syndrome, nokukhuluphala. Ososayensi nabasebenzi bezempilo banqume ukuthi ukuzila ukudla kungagcizelela umzimba womuntu ngendlela enenzuzo. Lokhu kucindezeleka kuzuzisa amagciwane anempilo epheshaneni lesisu (GI) ngoba kusiza ukwenza kusebenze i-autophagy noma inqubo yemvelo yokukhipha ubuthi beselula. Esihlokweni esilandelayo, sizoxoxa ngokuthi ukuzila ukudla kanye ne-autophagy kungakhuthaza kanjani impilo yokugaya. �

Ukuzila ukudla kanye ne-Autophagy Overview

Ipheshana lethu le-gastrointestinal (GI) livame ukuba nomsebenzi onzima wokuzama ukulungisa amangqamuzana ethu kuyilapho sishanela imfucumfucu engagayekile ukuze ikhiphe njengemfucuza ngoba abantu abaningi bahlala bedla usuku lonke. Abantu abaningi bamelene ngokuphelele nomqondo wokuzila ukudla, noma ukweqa ngokuzithandela ukudla okukodwa noma okubili ngosuku, naphezu kwezinzuzo zako maqondana nempilo yethu yokugaya. Ngenxa yokuthi kunezinhlobonhlobo zezindlela namasu okuzila ukudla, abantu abaningi bangalandela le ndlela yamasu yokudla futhi basasebenzise zonke izinzuzo zayo zezempilo zokugaya ukudla. Ukuzila ukudla, nokho, kungase kungabi okwawo wonke umuntu. �

Ngokomlando, imikhuba eminingi yezenkolo nengokomoya yayisebenzisa ukuzila njengento ebalulekile esikweni labo ukukhuthaza impilo yonke yokugaya ukudla. Njengamanje kunezinhlobonhlobo zezindlela nezindlela zokuzila ukudla ezisetshenziselwa ukusekela inhlalakahle yemvelo. Ngaphezu kwalokho, izinzuzo zokwelashwa zokuzila ukudla manje sezibonakala kalula ezifundweni eziningi zocwaningo. Izinhlobo ezahlukene zokuzila zingagcina zihluke ekudleni okuncane kakhulu noma zingadli lutho isikhathi esithile ukuya ekuphuzeni amanzi kuphela isikhathi esithile, ngezikhathi ezithile kuze kube yizinsuku ezinhlanu, njengendlela yokuthuthukisa ngokwemvelo impilo yokugaya ukudla. �

Ukuzila ukudla ngezikhathi ezithile, indlela yamasu yokudla elandela ukushintsha phakathi kokudla okunganqunyelwe kanye nokudla okulinganiselwe isikhathi esithile, kungenye yezindlela ezivame kakhulu nezisebenzayo zokuzila ukudla kuwo wonke umuntu. Ososayensi babheka ukuzila ukudla ngezikhathi ezithile njengokuphephile futhi okusebenzayo ngoba uhlala ngaphandle kokudla noma yikuphi ukudla isikhathi esifushane. Ucwaningo luye lwabonisa ukuthi ukusebenzisa ukuzila ukudla ngezikhathi ezithile amahora angu-16 nsuku zonke kwanele ukudala umkhawulo wekhalori odingekayo ukuze uthole izinzuzo zokuzila ukudla kanye nokwenza kusebenze i-autophagy ukusiza ukubuyisela impilo yokugaya ukudla. �

Ukudla okungu-5:2 kuyindlela ehlakaniphile yokudla lapho umuntu edla ukudla okulinganiselwe izinsuku ezinhlanu bese enciphisa kakhulu ukudla kwakhe abe ingxenye yesine yalokho kokudla okuvamile kwezinye izinsuku ezimbili zesonto. Zonke izindlela zokuzila zihlukile kodwa inhloso yokuzithiba noma ukunciphisa ukudla iwukuba sinikeze i-gut microbiome yethu ikhefu ekugayekeni ukuze bakwazi ukugxila ekulungiseni amangqamuzana ethu kuyilapho beshanela imfucumfucu engagayeki nama-bacterium amaningi ukuze kususwe njengemfucuza. Ucwaningo locwaningo luphakamisa ukuthi ukudla okungu-16:8 kungase kube indlela elula yokuzila ukudla noma indlela abantu abangayilandela. �

Ukuzila Ukudla kanye Ne-Autophagy Isekela Impilo Yokugaya

Amanyikwe ethu ngokuvamile abangela ukukhululwa kweglucagon lapho sinoshukela wegazi ophansi kuyilapho ukukhishwa kwe-insulin kuqaliswa ukusiza ukwehlisa amazinga kashukela egazi. I-insulin iyancipha futhi i-glucagon iyanda ngesikhathi sokuzila ukudla okuye kwaboniswa ukusiza ukuthuthukisa imetabolism kanye nokunikeza amandla, ukushintsha kwemizwelo, nokuncipha kwesisindo. Ukuzila ukudla futhi kusiza ukukhuthaza ukwakheka “okunempilo” kwe-gut microbiome yethu noma inani labantu bamagciwane “anempilo” epheshaneni lethu lesisu (GI). Ososayensi bahlobanise ukuzila ukudla nokusebenzisa isakhi sofuzo esisekela impilo yonke yokugaya ukudla. �

Impilo ekahle yokugaya ukudla kanye nama-bacterium amathumbu “anempilo” abalulekile ukuze asisize ekusivikeleni kumabhaktheriya angajwayelekile noma adlulele, ubuthi, nezinye izinhlanganisela ezingavusa amasosha omzimba. Okokugcina, ukuzila ukudla kungasiza ekubuyiseleni ubuqotho bolwelwesi lwamathumbu ngokulawula ukuvuvukala okungasiza ekugcineni ukuvikela umzimba womuntu ngokumelene nezimo ezihlukahlukene nezifo ezihambisana nokuvuvukala. Inzuzo eyinhloko yokuzila ukuthi ingakhuphula i-autophagy noma inqubo yemvelo ye-detoxification yamaselula. Ngokuzila ukudla, impilo yamathumbu akho iyathuthuka futhi unciphisa ubungozi bezinkinga zempilo ezahlukahlukene zokugaya ukudla. �

Ukuzila ukudla kuyindlela eyaziwayo, enamasu yokudla engaba nezinhlobonhlobo zezinzuzo zezempilo zokugaya ukudla kubantu abaningi. Abantu abaningi bangazuza kakhulu ngokuzila ukudla. Ukuzila ukudla kungenza kusebenze i-autophagy, noma inqubo yemvelo yokukhipha ubuthi emzimbeni, ukusiza ukushanela amagciwane amaningi kanye nemfucumfucu yokudla engagayekile ukuze kuqedwe njengemfucuza, kuphinde kusebenze izinqubo zokulwa nokuvuvukala ukuze kuncishiswe ukuvuvukala kanye nengcindezi ye-oxidative. Nokho, kubalulekile ukukhumbula ukuthi ukuzila kungase kungabi okwawo wonke umuntu. Qiniseka ukuthi ukhuluma nodokotela oqeqeshiwe nonolwazi ngaphambi kokuzama noma yiziphi izindlela zokuzila ukudla. - UDkt Alex Jimenez DC, CCST Insight

Ifomu Lokuhlola I-Neurotransmitter

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Kukhethwe nguDkt. Alex Jimenez �

References:

�Umthelela Wokuzila Ukudla Kwi-Microbiome Yakho.� Naomi Whittel, 12 Mar. 2019, www.naomiwhittel.com/the-impact-of-fasting-on-your-microbiome/.

Ingxoxo Yesihloko Eyengeziwe: Ubuhlungu Obungamahlalakhona

I-Neural Zoomer Plus Yezifo Zezinzwa

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Ukuzwela Kokudla kwe-IgG & IgA Immune Response

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I-Gut Zoomer Yokukhula Kwamagciwane Amathumbu Amancane (SIBO)

Amafomula Okwesekwa kwe-Methylation

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Ngokuziqhenya,�UDkt Alexander Jimenez yenza amafomula e-XYMOGEN atholakale ezigulini ezingaphansi kwethu kuphela.

Sicela ushayele ihhovisi lethu ukuze sinikeze ukubonisana nodokotela ukuze sifinyelele ngokushesha.

Uma uyisiguli se I-Injury Medical & Chiropractic�Umtholampilo, ungase ubuze mayelana ne-XYMOGEN ngokushaya ucingo 915-850-0900.

Ukuze kube lula kuwe futhi ubuyekeze i- XYMOGEN imikhiqizo sicela ubuyekeze isixhumanisi esilandelayo. *XYMOGEN-Ikhathalogi-Thwebula �

* Zonke izinqubomgomo ze-XYMOGEN ezingenhla zisasebenza ngokuqinile. �

� ? ?

I-Functional Neurology: Isayensi Yokuzila Ukudla Kwempilo Yokugaya

by UDkt Alex Jimenez | Ukuzila, Umuthi Osebenzayo, I-Gastro Intestinal Health, Amathumbu kanye Nempilo Yamathumbu, Impilo, Imvelo yemvelo, Nutrition, Ubuhle

Kubantu abaningi, ukuzila ukudla, noma umqondo wokweqa ukudla ngokuzithandela isikhathi esithile, kungase kungabonakali njengendlela ekhangayo kakhulu yokuthuthukisa impilo yokugaya ukudla. Ngoba abantu abaningi futhi badla cishe ukudla oku-3 ngosuku, ukweqa ukudla okukodwa noma okubili ngosuku ekugcineni kungabenza bazizwe beguquguquka, bekhathele, futhi bekhathele. Kodwa-ke, kubantu abanezinkinga zempilo yokugaya ukudla, njenge-SIBO, IBS, noma amathumbu avuzayo, kungenzeka ukuthi sebezizwa lezi zimpawu, ngisho nangemva kokudla ukudla kwabo oku-3 ngosuku. Kulesi sihloko, sizoxoxa ngokuthi ukuzila ukudla kungaba yinzuzo kanjani kwezinye iziguli nokuthi kungasiza kanjani ekuthuthukiseni impilo yazo yokugaya. �

Ukuqonda Uhlelo Lokugaya ukudla

Isimiso sokugaya ukudla siqala inqubo yokuhlephula ukudla kusukela lapho sidla ukuze simunce imisoco, njengamavithamini namaminerali. Uhlelo lokugaya luzosebenzisa cishe amaphesenti angu-25 amakholori esiwadlayo ukuze siqale ngisho nenqubo yokugaya. Ukugaya ukudla kudinga umzamo omkhulu ovela emzimbeni womuntu ngoba kushintsha imisebenzi yakho eminingi eyinhloko futhi kudonsele izinsiza eziningi kude kwezinye izakhiwo ukuze kumane kukwenze. Amasosha omzimba aphinde asebenze njalo lapho sidla ukudla ukuze avikele i-gastrointestinal, noma i-GI, ipheshana kunoma yini nako konke okudlulayo. �

Nokho, lapho uzila ukudla, isimiso sokugaya ukudla singaqala ukuphulukisa futhi sibuyisele umzimba womuntu. Ngesikhathi sokuzila ukudla, umzimba womuntu uzosebenzisa amafutha esikhundleni sikashukela njengomthombo oyinhloko wamandla kaphethiloli. Umuntu ojwayelekile une-2,500 Kcal kuphela ye-glycogen ongayisebenzisa njengoshukela ukuze ube namandla kanti umuntu ojwayelekile une-100,000 Kcal wamafutha wamandla. Ngaphezu kwalokho, kungase kuthathe isikhathi ukuba umzimba womuntu ujwayele ukusebenzisa amafutha esikhundleni sikashukela njengomthombo oyinhloko wamandla kaphethiloli, yingakho abantu abaningi bengase bangazizwa kahle kuze kube yizinsuku ezimbalwa beqale ukuzila ukudla. Ukuzila ukudla nakho kungase kube nezinye izinzuzo ekugcineni. �

Ukuvuvukala

Ukuvuvukala kungenye yezimbangela eziyinhloko zezimo ezihlukahlukene ezingapheli kanye nezifo, kuhlanganise nezinkinga zempilo yokugaya. Ngokusho kwabacwaningi nabasebenzi bezempilo, ukuvuvukala kuyimbangela evamile ye-SIBO, ukugcwala kwamagciwane emathunjini amancane, i-IBS, i-inflammatory bowel syndrome, kanye namathumbu avuzayo. Izici zemvelo, njengobuthi, ukudla okugayiwe, izidakamizwa kanye/noma imithi, utshwala, nokungezwani nokudla noma ukungabekezelelani konke kungabangela ukuvuvukala. Ngaphezu kwalokho, ukucindezeleka kungabangela ukuvuvukala futhi kungathinta kakhulu inqubo yokugaya kanye nempilo yonke yokugaya. �

Akukho ukudla okuzogcina kudlule epheshaneni lesisu, noma i-GI, ngesikhathi sokuzila ukudla. Ngaphandle kwamanzi, ukuzila ukudla kunciphisa ukusetshenziswa kwamakhemikhali okuvuvukala, kuqhubeke nokunciphisa ukuvuvukala emzimbeni womuntu. Ama-cytokines alwa nokuvuvukala aqala ukusebenza kuyilapho ama-cytokine abangela ukuvuvukala engasebenzi uma ezila. Isistimu yokugaya iyazi uma singadli futhi izogcina icuphe lezi zinguquko zesakhiwo nokusebenza. Ukuvuvukala nakho kuhlotshaniswa eduze nokucindezeleka okwenziwe nge-oxidative. Ukucindezeleka kwe-oxidative nokuvuvukala kungathinta impilo yethu yonke yokugaya. �

Ukucindezeleka Oxidative

Ukuzila ukudla kungasiza ekunciphiseni ukuvuvukala nokucindezeleka okwenziwe nge-oxidative ngokusebenzisa izakhi zethu zofuzo. Ukucindezelwa kwe-oxidative kubhekisela emonakalweni owenzeka kumaseli nezicubu zomzimba womuntu lapho evezwe izinto ezihlukahlukene zemvelo, njengobuthi. Amaprotheni, i-lipids, ngisho ne-DNA yamangqamuzana ethu angathinteka ukuvuvukala nokucindezeleka okwenziwe nge-oxidative, ukuguqula ukwakheka nokusebenza kwamaseli. Ukudla ama-antioxidants kungasiza ekunciphiseni ukuvuvukala nokucindezeleka okwenziwe nge-oxidative. Kubalulekile ukuthi uqiniseke ukuthi udla ama-antioxidants anele uma ungazili ukuze uvikele ukulimala kwamaseli ekuvuvukeni nasekucindezelekeni kwe-oxidative.

Ukuzila ukudla kanye ne-MMC Yezempilo Yokugaya

Abacwaningi kanye nabasebenzi bezempilo baphakamise ukuthi ukuthuthukiswa kwezinkinga ezimbalwa zezempilo zokugaya ukudla, okuhlanganisa i-SIBO, i-IBS, kanye namathumbu avuzayo, kuhlotshaniswa namazinga akhulayo ama-enzyme oxidative kanye nokuncipha kwamanani e-antioxidant enzymes. Kodwa-ke, umthombo oyinhloko walezi zinkinga zezempilo zokugaya ekugcineni ubandakanya i-gut microbiome noma amagciwane asemathunjini. Ukukhula kwebhaktheriya emathunjini amancane, noma i-SIBO, inkinga yezempilo yokugaya ebangelwa ukukhula ngokweqile kwamagciwane emathunjini amancane, agcine eholela ekuvuzeni kwamathumbu noma ukungeneka kwamathumbu, phakathi kwezinye izinkinga. �

Ngokwezifundo zocwaningo kanye nokuhlolwa komtholampilo, ukuzila ukudla kungasiza ekuguquleni inani labantu be-gut microbiome, kukhuthaze ukulawulwa kwamagciwane "anempilo". Le nqubo yokugaya ekugcineni ilawulwa yi-motor complex complex noma i-MMC. I-MMC iyinqubo yokugaya elawula futhi igcine ukufinyela kwepheshana lesisu, noma i-GI, phakathi nenkathi ethile yesikhathi. Inxanxathela yezimoto ezifudukayo isiza ukushanela amagciwane kanye nemfucumfucu engagayekile ukuze iqedwe njengodoti. Izimpawu ze-Neurohormonal, njenge-somatostatin, i-serotonin, i-motilin, ne-ghrelin, zilawula i-MMC lapho udla futhi uzila ukudla. �

Umsebenzi we-MMC uqala lapho sizilile noma siphakathi kokudla. Uma sesidle ukudla, nokho, imisoco efana namavithamini namaminerali ingaba nomthelela ekusebenzeni kwe-motor complex complex, ekugcineni yehle lapho umsebenzi we-MMC iqala, futhi empeleni iqale inqubo yokugaya futhi. Uma sivumela i-MMC ukuthi iqedele umsebenzi wayo ngesikhathi sokuzila ukudla, kungaba nzima kakhulu ukuthi ukudla, imfucumfucu engagayeki, kanye namagciwane adlulele ahlale ethunjini, noma i-GI, ipheshana. Yingakho ukuzila kunconyiwe njengokwelashwa kwe-SIBO. Nokho, ukuzila ukudla kungase kungafaneleki kuwo wonke umuntu. Nakuba ukuzila ukudla kungase kube nezinzuzo ezihlukahlukene zezempilo zokugaya ukudla, qiniseka ukuthi uthintana nodokotela ngaphambi kokuqala noma yiluphi uhlelo lokwelapha lokuzila noma uhlelo. �

Ukuzila ukudla kuyindlela eyaziwayo, enamasu yokudla engaba nezinhlobonhlobo zezinzuzo zezempilo zokugaya ukudla kubantu abaningi. Izinkinga ezimbalwa zezempilo zokugaya ukudla, njenge-SIBO, IBS, kanye namathumbu avuzayo, zingazuza kakhulu ngokuzila ukudla. Ukukhula kwebhaktheriya emathunjini amancane, noma i-SIBO, yinkinga yezempilo enzima eyenza amagciwane amaningi akhule emathunjini amancane. Ukuzila ukudla kungakhuthaza inkimbinkimbi yezimoto ezifudukayo, noma i-MMC, ukuthi isebenze, ishanele amagciwane amaningi kanye nemfucumfucu engagayekile ukuze iqedwe njengemfucuza, kuphinde kuvuse izinqubo zokulwa nokuvuvukala ukuze kuncishiswe ukuvuvukala kanye nengcindezi ye-oxidative. Nokho, ukuzila ukudla kungase kungabi okwawo wonke umuntu. Qiniseka ukuthi ukhuluma nochwepheshe bezempilo abaqeqeshiwe nabanolwazi ngaphambi kokuzila ukudla. - UDkt Alex Jimenez DC, CCST Insight

Ifomu Lokuhlola I-Neurotransmitter

Kubantu abaningi, ukuzila ukudla, noma umqondo wokweqa ukudla ngokuzithandela isikhathi esithile, kungase kungabonakali njengendlela ekhangayo kakhulu yokuthuthukisa impilo yokugaya ukudla. Ngoba abantu abaningi futhi badla cishe ukudla oku-3 ngosuku, ukweqa ukudla okukodwa noma okubili ngosuku ekugcineni kungabenza bazizwe beguquguquka, bekhathele, futhi bekhathele. Kodwa-ke, kubantu abanezinkinga zempilo yokugaya ukudla, njenge-SIBO, IBS, noma amathumbu avuzayo, kungenzeka ukuthi sebezizwa lezi zimpawu, ngisho nangemva kokudla ukudla kwabo oku-3 ngosuku. Kulesi sihloko, sixoxe ngokuthi ukuzila ukudla kungaba yinzuzo kanjani kwezinye iziguli nokuthi kungasiza kanjani ukuthuthukisa impilo yazo yokugaya. �

Kukhethwe nguDkt. Alex Jimenez �

References:

Rory. �Uwelapha Kanjani Amathumbu Akho Ngokuzila Ukudla.� I-Chewsomegood, I-MSc Personalized Nutrition, 9 Aug. 2018, www.chewsomegood.com/fasting-ibs/.

Ingxoxo Yesihloko Eyengeziwe: Ubuhlungu Obungamahlalakhona

I-Neural Zoomer Plus Yezifo Zezinzwa

Ukuzwela Kokudla kwe-IgG & IgA Immune Response

I-Gut Zoomer Yokukhula Kwamagciwane Amathumbu Amancane (SIBO)

�

Amafomula Okwesekwa kwe-Methylation

Ngokuziqhenya,�UDkt Alexander Jimenez yenza amafomula e-XYMOGEN atholakale ezigulini ezingaphansi kwethu kuphela.

Sicela ushayele ihhovisi lethu ukuze sinikeze ukubonisana nodokotela ukuze sifinyelele ngokushesha.

Uma uyisiguli se I-Injury Medical & Chiropractic�Umtholampilo, ungase ubuze mayelana ne-XYMOGEN ngokushaya ucingo 915-850-0900.

Ukuze kube lula kuwe futhi ubuyekeze i- XYMOGEN imikhiqizo sicela ubuyekeze isixhumanisi esilandelayo. *XYMOGEN-Ikhathalogi-Thwebula �

* Zonke izinqubomgomo ze-XYMOGEN ezingenhla zisasebenza ngokuqinile. �

� ? ?

Ukuqonda Ukuzila Ukudla Kwesikhashana

by UDkt Alex Jimenez | Ukuzila, Umuthi Osebenzayo, Impilo, Weight Loss, Ubuhle

Ingabe uzizwa:

Ulambile ngemva kwehora noma amabili ngemva kokudla?
Ukuzuza kwesisindo okungachazwanga?
Ukungalingani kweHormonal?
Umqondo ophelele wokuqunjelwa?
Umuzwa wokugcwala phakathi nangemuva kokudla?

Uma uhlangabezana nanoma yisiphi salezi zimo, zama ukucabangela ukuzila ukudla kwesikhashana.

Selokhu kwaduma eminyakeni yamuva nje, ukuzila ukudla ngezikhathi ezithile kuyindlela yokudla abantu abaningi abebeyisebenzisa endleleni yabo yokuphila enempilo. Ngesikhathi somphakathi wabazingeli, abantu baye basebenzisa le ndlela amakhulu eminyaka njengendlela yokuphila. Ucwaningo luye lwaboniswa ukuthi abantu bayisebenzisela izinjongo zokwelapha emlandweni wonke njengekhambi lokwelapha. AmaRoma asendulo, impucuko yamaGreki namaShayina yayisebenzisa ukuzila ukudla ngezikhathi ezithile ekuphileni kwabo kwansuku zonke. Ukuzila ukudla kuze kusetshenziselwe izizathu ezingokomoya ezinkolweni ezithile, njengeBuddhism, Islam, kanye nobuKristu njengabantu ngabanye bakusebenzisa njengendlela yokuzindla futhi basondelane nonkulunkulu babo.

Kuyini Ukuzila?

Ukuzila ukudla yilapho umuntu engakudli ukudla noma iziphuzo okungenani amahora ayishumi nambili emini. Lapho umuntu eqala ukuzila ukudla, uzoqaphela ukuthi umzimba wakhe kanye namahomoni azoshintsha emizimbeni yakhe. Nakhu ucwaningo oluzayo ukuthi ukuzila ukudla ngezikhathi ezithile kungakhuthaza izinzuzo zezempilo ezimangalisayo emzimbeni. Izinzuzo zezempilo ezilethwa ukuzila ukudla ngezikhathi ezithile ukuncipha kwesisindo, imiphumela evikelayo ebuchosheni, ukuncipha kokuvuvukala nokuthuthukisa izinga likashukela egazini kanye namazinga e-insulin emzimbeni.

Izindlela Ezihlukene

Bangu ezinye izindlela zokuzila ukudla lokho kuhilela ukuzila ukudla izinsuku ezimbalwa noma amasonto. Ngalezi zindlela ezahlukene, zibandakanya isikhathi esifushane esiphakathi kwamahora ayi-16 kuya kwangama-24. Izinhlobo eziningana zokuzila ukudla ngezikhathi ezithile zinqunywa ubude besikhathi sewindi lokuphakela (ukuthi udle nini ukudla) kanye newindi lokuzila (ukugwema nini ukudla). Nazi ezinye zezindlela zokuzila ukudla, ezihlanganisa:

Ukondla okukhawulelwe isikhathi (TRF): Lolu hlobo lokuzila lunenkathi yewindi lokuphakela kusukela emahoreni ama-4 kuye kwayi-12. Esikhathini esisele sosuku, amanzi ukuphela kwento evunyelwe ukusetshenziswa. Ukuhluka okuvamile kokudla lolu hlobo lokuzila ukudla kungu-16/8. Lokhu kusho ukuthi umuntu kufanele azile ukudla okungenani amahora ayi-16 nsuku zonke.
Ukondla okukhawulelwe kusenesikhathi (i-eTRF): Lolu uhlobo oluhlukile lokuzila ukudla okukhawulelwe isikhathi olusuka ku-8am kuya ku-2pm Ngemva kokuba amahora angu-6 esephelile, lonke usuku lwenziwa yilesi sikhathi sokuzila.
Okunye ukuzila ukudla kosuku (ADF): Lolu hlobo lokuzila lubandakanya ukuthi umuntu adle usuku olulodwa futhi ngakusasa azile ngokuphelele. Bashintshana phakathi kokudla nokuzila ukudla usuku ngalunye ukuze bathole izinzuzo.
Ukuzila ukudla kwesikhathi (ukuzila ukudla ngamabhayisikili): Lolu hlobo lokuzila ukudla luhlanganisa ukuzila ukudla kosuku olulodwa noma ezimbili ngesonto kanye nolwesihlanu noma lwesithupha lokudla ngendlela umuntu afisa ngayo. Izinhlobonhlobo zokuzila isikhathi zingaba ngu-5:2 noma u-6:1.
Ukuzila ukudla okushintshiwe: Lolu hlobo lokuzila lunezindlela ezithile zokuzila ukudla ngezikhathi ezithile ezifana nokuzila okunye kosuku, kodwa lokhu kuzila kungalungiselelwa noma ubani. Umuntu angadla izinto ezinekhalori ephansi kakhulu ngesikhathi sokuzila ukudla.

Isebenza kanjani?

Ukuzila ukudla ngezikhathi ezithile kuwumphumela wezinguquko emzimbeni njengoba amaphethini ama-hormone kanye nokusetshenziswa kwamandla kuthinteka. Uma umuntu eseqedile ukudla ukudla, okuphakathi kuyahlakazwa bese kuguqulwa kube imisoco, ngakho kungamuncwa emgudwini wokugaya ukudla. Okwenzekayo ukuthi ama-carbohydrates ayaphulwa aphenduke abe ushukela bese emunca egazini, alisabalalise esicutshini somzimba njengomthombo wamandla obalulekile. Ihomoni ye-insulin ibe isisiza ukulawula amazinga kashukela egazini ngokusayina amaseli ukuthi athathe ushukela egazini bese ephenduka abe uphethiloli ukuze umzimba usebenze kahle.

Ngokuzila ukudla ngezikhathi ezithile, umuntu udliwa ngokudla futhi amazinga eglucose ayancipha emzimbeni. Ukuze amandla ahlangabezane nezidingo zawo umzimba kufanele uphule i-glycogen etholakala esibindini nasemisipha yamathambo ebangela i-gluconeogenesis. I-Gluconeogenesis yilapho isibindi sikhiqiza ushukela we-glucose emithonjeni engewona ama-carbohydrate emzimbeni. Bese kuthi lapho amazinga e-insulin ephansi ngemva kwamahora angu-18 wokuzila ukudla, inqubo ebizwa ngokuthi i-lipolysis iyaqala. Okwenziwa yi-lipolysis ukuthi umzimba uqala ukudiliza izingxenye zamafutha zibe ama-fatty acids mahhala. Uma kunenani eliphansi le-glucose ukuze umzimba ulisebenzise ukuze uthole amandla, umzimba ngokwawo uqala ukusebenzisa ama-fatty acids nama-ketone ukuze uthole amandla. I-Ketosis isimo se-metabolic lapho amangqamuzana esibindi eqala ukusiza ukuwohloka kwe-fatty acids futhi awaguqule abe yi-ketone acetoacetate kanye ne-beta-hydro butyrate.

Amaseli emisipha namaseli e-neuron asebenzisa la ma-ketone ukuze akhe i-ATP (i-adenosine triphosphate) okuyiyona ethwala amandla. Ucwaningo selushilo ukuthi ukusetshenziswa nokutholakala kwe-fatty acids ehlanganiswe nama-ketones njengendlela yokushintsha amandla eglucose kunenzuzo ezicutshini ezibalulekile zomzimba. Lokhu kuhlanganisa inhliziyo, isibindi, amanyikwe nobuchopho.

Izimo ezine ze-metabolic zibangelwa ukuzila zibizwa ngokuthi umjikelezo owondliwe ngokushesha, futhi yilezi:

Izwe elidlayo
Isimo se-post-absorptive
Isimo sokuzila ukudla
Isimo sokulamba

Umphumela wokuphila wokuzila ukudla okuphakathi nawo ungafinyelelwa ngokulandela ukudla kwe-ketogenic, okunamafutha amaningi kakhulu kanye nokudla okuphansi kwe-carbohydrate. Inhloso yalokhu kudla ukuguqula isimo se-metabolic somzimba sibe yi-ketosis.

Izinzuzo Zokuzila

Kunamathani ocwaningo olukhombisile ukuthi ukuzila ukudla kwesikhashana kunezinhlobo eziningi zezinzuzo zezempilo, okuhlanganisa:

Ukwehla kwesisindo
Thayipha isifo sikashukela sohlobo 2 nokuphathwa
Izici ezithuthukisiwe zengozi ye-cardiometabolic
Ukuhlanzwa kwamaselula
Ukunciphisa ukuvuvukala
neuroprotection

Ucwaningo luye lwaboniswa ukuthi izindlela ezimbalwa ezihlongozwayo zinesibopho sale miphumela yezempilo yokuzila ukudla kwezikhawu futhi zibonise ukuthi zinenzuzo endleleni yokuphila yomuntu.

Isiphetho

Ukuzila ukudla ngezikhathi ezithile kuye kwenziwa amakhulu eminyaka futhi sekuzuze ukuthandwa eminyakeni yamuva. Kuhilela ukuyeka ukudla ukudla okungenani amahora angu-12 alandelanayo ngokuguqula amangqamuzana amafutha abe amandla ukuze umzimba usebenze. Izinzuzo zezempilo ezilethwa ukuzila ukudla kwesikhashana zinenzuzo kumuntu ozama ukulondoloza indlela yokuphila enempilo. Abanye imikhiqizo ukusiza ukunikeza ukusekelwa ohlelweni lwe-gastrointestinal kanye nokuqinisekisa ukuthi i-metabolism kashukela isezingeni elinempilo ukuze umzimba usebenze.

References:

Dhillon, Kiranjit K. �Biochemistry, Ketogenesis.� StatPearls [I-inthanethi]., Ilabhulali Kazwelonke Yezokwelapha yase-US, 21 Apr. 2019, www.ncbi.nlm.nih.gov/books/NBK493179/#article-36345.

U-Hue, uLouis, no-Heinrich Taegtmeyer. �Umjikelezo weRandle Uphinde Wavakashelwa: Inhloko Entsha Yesigqoko Esidala.� Ijenali yaseMelika yePhysology. I-Endocrinology neMetabolism, I-American Physiological Society, Sept. 2009, www.ncbi.nlm.nih.gov/pmc/articles/PMC2739696/.

Stockman, Mary-Catherine, et al. �Ukuzila Ukudla Kwezikhawu: Ingabe Ukulinda Kuyanelisa Isisindo?� Imibiko Yamanje Yokukhuluphala, I-US National Library of Medicine, Juni 2018, www.ncbi.nlm.nih.gov/pmc/articles/PMC5959807/.

Zubrzycki, A, et al. �Iqhaza Lokudla Okunekhalori Ephansi kanye Nokuzila Ukudla Kwesikhashana Ekwelapheni Ukukhuluphala kanye Nesifo Sikashukela Sohlobo 2.� Ijenali yePhysiology and Pharmacology: Ijenali Esemthethweni ye-Polish Physiological Society, I-US National Library of Medicine, Oct. 2018, www.ncbi.nlm.nih.gov/pubmed/30683819.

Ukuzila Ukudla Nomdlavuza: Izindlela Zemolekyuli kanye Nesicelo Somtholampilo

by UDkt Alex Jimenez | Ukuzila

Alessio Nencioni, Irene Caffa, Salvatore Cortellino futhi Valter D. Longo

Abstract | Ukuba sengozini kwamangqamuzana omdlavuza ekusweleni izakhi kanye nokuncika kwawo kuma-metabolite athile kuyizimpawu ezivelayo zomdlavuza. Ukudla okuzila ukudla noma ukudla okulingisa ukudla (FMDs) kuholela ekuguqulweni okubanzi kwezici zokukhula kanye namazinga e-metabolite, izindawo ezikhiqizayo ezinganciphisa amandla amangqamuzana omdlavuza ukuze azivumelanise futhi aphile futhi ngaleyo ndlela athuthukise imiphumela yokwelapha umdlavuza. Ukwengeza, ukuzila ukudla noma ama-FMD akhulisa ukumelana ne-chemotherapy kumangqamuzana omdlavuza evamile kodwa hhayi omdlavuza futhi akhuthaze ukuvuselelwa kwezicubu ezivamile, ezingasiza ekuvimbeleni imiphumela emibi yokwelashwa eyingozi futhi engase ibe yingozi empilweni. Nakuba ukuzila ukudla kungabekezelelwa iziguli, izifundo zezilwane nezomtholampilo zibonisa ukuthi imijikelezo yama-FMD anekhalori ephansi iyenzeka futhi iphephile ngokuphelele. Izivivinyo eziningana zomtholampilo ezihlola umphumela wokuzila ukudla noma ama-FMD ezenzakalweni ezimbi ezivela ekwelapheni kanye nemiphumela yokusebenza ngempumelelo ziyaqhubeka. Siphakamisa ukuthi inhlanganisela yama-FMD ane-chemotherapy, i-immunotherapy noma ezinye izindlela zokwelapha imele isu elingase lithembise ukukhulisa ukusebenza kahle kokwelashwa, ukuvimbela ukutholwa kokumelana nokunciphisa imiphumela emibi.

Izici eziphathelene nokudla kanye nendlela yokuphila ziyizici ezibalulekile zengozi yokuba nomdlavuza, nemidlavuza ethile encike kakhulu emikhubeni yokudla kunabanye1�I-9. Ngokuvumelana nalo mbono, ukukhuluphala kulinganiselwa ku-14% kuya ku-20% wabo bonke abantu ababulawa umdlavuza e-United. States7, okuholela eziqondisweni zokudla okunomsoco kanye nokusebenza ngokomzimba ukuze kuncishiswe ubungozi bokuthuthuka umdlavuza6. Ngaphezu kwalokho, uma kubhekwa ukuthambekela okuvelayo kwamangqamuzana omdlavuza, kodwa hhayi kwezicubu ezivamile, ukungalaleli izimpawu eziphikisana nokukhula (ngenxa yokuguqulwa kwe-oncogenic) 10 kanye nokungakwazi ukuzivumelanisa kahle nezimo zokuzila11,12, kunesithakazelo esikhulayo sokuthi kungenzeka ukuthi. ukudla okuthile okunekhalori okulinganiselwe kungase futhi kube yingxenye ebalulekile yokuvimbela umdlavuza futhi, mhlawumbe, ukwelashwa komdlavuza njengendlela yokwandisa ukusebenza kahle nokubekezelelana kwama-anticancer agents11�13.

Ngisho noma kule minyaka eyishumi edlule sibone izinguquko ezingakaze zibonwe kanye nentuthuko emangalisayo ekwelashweni komdlavuza14,15, kusenesidingo esibalulekile sokuphumelela kakhudlwana futhi, mhlawumbe, izindlela zokwelapha ngoba izimila kodwa futhi, futhi okubaluleke kakhulu, ngamasu okunciphisa imiphumela emibi yokwelashwa komdlavuza15,16. Udaba lwezehlakalo ezimbi eziqhamuka ekwelapheni (TEAEs) lungenye yezithiyo eziyinhloko ku-oncology yezokwelapha15,16. Eqinisweni, iziguli eziningi ezinomdlavuza zithola imiphumela emibi kakhulu kanye/noma yesikhathi eside yokwelashwa komdlavuza, okungase kudinge ukulaliswa esibhedlela kanye nokwelashwa okunonya (njengama-antibiotics, i-hematopoietic izici zokukhula futhi ukumpontshelwa igazi) futhi kuthinte kakhulu izinga lempilo yabo (ngokwesibonelo, ukwelashwa ngamakhemikhali I-peripheral neuropathy) 16. Ngakho-ke, amasu asebenzayo okunciphisa ubuthi afanelekile futhi kulindeleke ukuthi abe nomthelela omkhulu kwezokwelapha, kwezenhlalo nakwezomnotho15,16.

Ukuzila ukudla kuphoqa amangqamuzana anempilo ukuthi angene ekuhlukaneni kancane kanye nemodi evikelwe kakhulu ewavikela ekuthukweni okunobuthi okuvela emithini elwa nomdlavuza kuyilapho eqwashisa izinhlobo ezahlukene zamangqamuzana omdlavuza kulezi zindlela zokwelapha11,12,17. Lokhu kutholakala kusho ukuthi ukungenelela kokudla okukodwa kungasiza ukubhekana nezici ezihlukene nezibaluleke ngokulinganayo zokwelashwa komdlavuza.

Kulesi sihloko se-Opinion, sidingida isisekelo sebhayoloji sokusebenzisa ukudla okuzila ukudla noma okulingisa ukudla (ama-FMD) ukufiphaza ama-TEAE kodwa futhi ukuvikela nokwelapha umdlavuza. Siphinde sibonisa izixwayiso zale ndlela yokuhlola18,19 kanye nezifundo zomtholampilo ezishicilelwe neziqhubekayo lapho ukuzila ukudla noma ama-FMD asetshenziswe ezigulini ezinomdlavuza.

Impendulo Yokuzila Okuhlelekile Neselula

Ukuzila ukudla kuholela ekushintsheni komsebenzi wezindlela eziningi ze-metabolic ezihlotshaniswa nokushintshela kumodi ekwazi ukukhiqiza amandla nama-metabolites usebenzisa imithombo ye-carbon ekhishwe ngokuyinhloko kuzicubu ze-adipose futhi ngokwengxenye kusuka emisipha. Izinguquko emazingeni ama-hormone ajikelezayo kanye nama-metabolites ahumusha ekuncipheni kokuhlukana kwamaseli kanye umsebenzi we-metabolic yamangqamuzana avamile futhi ekugcineni awavikele ekuthukweni kwe-chemotherapeutic11,12. Amangqamuzana omdlavuza, ngokungalaleli imiyalo emelene nokukhula eshiwo yilezi zimo zendlala, angaba nokusabela okuphambene namaseli avamile futhi ngenxa yalokho abe nolwazi ngokwelashwa ngamakhemikhali nezinye izindlela zokwelapha zomdlavuza.

Impendulo Ehlelekile Yokuzila

Impendulo yokuzila ukudla ihlelwe ngokwengxenye ngamazinga ajikelezayo we-glucose, i-insulin, i-glucagon, i-hormone yokukhula (GH), i-IGF1, i-glucocorticoids. futhi i-adrenaline. Phakathi nesigaba sokuqala sangemva kokumuncwa, ngokuvamile esithatha amahora angu-6-24, amazinga e-insulin aqala ukwehla, futhi amazinga eglucagon akhuphuke, okuthuthukisa ukuwohloka kwezitolo ze-glycogen zesibindi (eziphelayo cishe ngemva kwamahora angu-24) kanye nokukhululwa kweglucose ukuze ibe namandla.

I-Glucagon namazinga aphansi e-insulin nawo avuselela ukuwohloka kwama-triglycerides (agcinwa kakhulu kuzicubu ze-adipose) abe i-glycerol kanye nama-fatty acids amahhala. Ngesikhathi sokuzila ukudla, izicubu eziningi zisebenzisa ama-acids anamafutha ukuze zibe namandla, kuyilapho ubuchopho buthembele ku-glucose kanye nemizimba ye-ketone ekhiqizwa ama-hepatocytes (imizimba ye-ketone ingakhiqizwa ku-acetyl-CoA ekhiqizwa ku-fatty acid ?-oxidation noma kuma-amino acid e-ketogenic). Esigabeni se-ketogenic sokuzila ukudla, imizimba ye-ketone ifinyelela ukugxila ebangeni le-millimolar, ngokuvamile eqala ngemva kwezinsuku ezingu-2�3 kusukela ekuqaleni kokuzila. Kanye ne-glycerol nama-amino acid asuselwa kumafutha, imizimba ye-ketone yenza i-gluconeogenesis, egcina amazinga eglucose enqwabelana cishe ku-4mM (70mg nge-dl ngayinye), esetshenziswa kakhulu ubuchopho.

I-Glucocorticoids ne-adrenaline nazo zinomthelela ekuqondiseni ukuguquguquka kwe-metabolic ukuzila ukudla, ukusiza ukugcina amazinga kashukela egazini kanye nokuvuselela i-lipolysis20,21. Ngokuphawulekayo, nakuba ukuzila ukudla okungenani kungakhuphula amazinga e-GH okwesikhashana (ukwandisa i-gluconeogenesis kanye ne-lipolysis kanye nokunciphisa ukuthathwa kwe-glucose ye-peripheral), ukuzila ukudla kunciphisa amazinga e-IGF1. Ukwengeza, ngaphansi kwezimo zokuzila ukudla, umsebenzi we-IGF1 wezinto eziphilayo uvinjelwe ngokwengxenye ngokunyuka kwamazinga e-insulin-like growth factor binding protein 1 (IGFBP1), ebophezela ekujikelezeni kwe-IGF1 futhi ivimbele ukusebenzisana kwayo ne-cell surface receptor22 ehambisanayo.

Okokugcina, ukuzila ukudla kunciphisa amazinga e-leptin ejikelezayo, i-hormone eyenziwa kakhulu yi-adipocyte evimbela indlala, kuyilapho ikhulisa amazinga e-adiponectin, okwandisa ukuwohloka kwe-fatty acid23,24. Ngakho-ke, ekuphetheni, izimpawu zokusabela kwesistimu yezilwane ezincelisayo ekuzileni ukudla zingamazinga aphansi e-glucose ne-insulin, amazinga aphezulu e-glucagon nemizimba ye-ketone, amazinga aphansi e-IGF1 ne-leptin namazinga aphezulu e-adiponectin.

Impendulo Yeselula Ngokuzila Ukudla

Ukusabela kwamaseli anempilo ekuzileni ukudla kugcinwa ngokuguquguqukayo futhi kunikeza ukuvikelwa kweseli, futhi okungenani ezintweni eziphilayo eziyimodeli, kuboniswe ukwandisa ubude bempilo kanye nempilo12,22,25�31. I-IGF1 ukusayina i-cascade iwukhiye ukusayina indlela ehilelekile ekulamuleni imiphumela yokuzila ukudla ezingeni lamaselula. Ngaphansi kokudla okujwayelekile, ukusetshenziswa kwamaprotheni kanye namazinga akhuphukayo ama-amino acids kwandisa amazinga e-IGF1 futhi akhuthaze umsebenzi we-AKT kanye ne-mTOR, ngaleyo ndlela kukhuliswe ukuhlanganiswa kwamaprotheni. Ngokuphambene nalokho, ngesikhathi sokuzila ukudla, amazinga e-IGF1 kanye nokwehla kokubonisa izimpawu ezingezansi, ukunciphisa ukuvinjelwa kwe-AKT-mediated of mammalian FOXO izici zokuloba nokuvumela lezi zici zokuloba ukuthi ziguqule izakhi zofuzo, okuholela ekusebenzeni kwama-enzyme afana ne-haem oxygenase 1 (HO1), i-superoxide dismutase ( SOD) kanye ne-catalase enemisebenzi ye-antioxidant nemiphumela yokuvikela32�34. Izinga le-glucose ephezulu livuselela i-protein kinase A (PKA) ukusayina, elawula kabi inzwa yamandla eyinhloko i-AMP-activated protein kinase (AMPK)35, yona, evimbela ukuvezwa kwesici sokumelana nengcindezi yokuphendula ukukhula kweprotheni 1 (EGR1) (Msn2 kanye/noma i-Msn4 kumvubelo)26,36 ,XNUMX.

Ukuzila ukudla kanye nomphumela wokuvinjelwa kwe-glucose kuvimbela umsebenzi we-PKA, ukwandisa umsebenzi we-AMPK futhi wenze kusebenze i-EGR1 futhi ngaleyo ndlela kuzuzwe imiphumela yokuvikela amaseli, kuhlanganise naleyo eku-myocardium22,25,26. Okokugcina, ukuzila ukudla kanye nama-FMD (bheka ngezansi ngokwakhiwa kwawo) nawo anamandla okukhuthaza imiphumela yokuvuselela (Ibhokisi 1) ngezindlela zamangqamuzana, ezinye zazo ezifakwe emdlavuzeni, njengokukhuphuka kwe-autophagy noma ukufakwa komsebenzi we-sirtuin22,37�49 .

Izindlela Zokudla Kuma-Cancer FMD

Izindlela zokudla ezisekelwe ekuzileni ukudla eziphenywe kabanzi ku-oncology, kokubili ngaphambi komtholampilo nangokomtholampilo, zihlanganisa ukuzila ukudla kwamanzi (ukuzila ukudla neziphuzo ngaphandle kwamanzi) kanye nama-FMDs11,12,17,25,26,50�60 (Ithebula 1). Idatha yokuqala yomtholampilo ikhombisa ukuthi kungadingeka ukushesha okungenani amahora angama-48 ukuze kuzuzwe imiphumela enenjongo emtholampilo ku-oncology, njengokuvimbela ukulimala kwe-DNA okubangelwa ngamakhemikhali ezicutshini ezinempilo kanye nokusiza ukulondoloza. isiguli izinga lempilo ngesikhathi sokwelashwa ngamakhemikhali52,53,61.

Kodwa-ke, iziguli eziningi ziyenqaba noma zinenkinga yokuqeda ukudla kwamanzi, futhi izingozi ezingase zibe khona zekhalori enwetshiwe kanye nokuntuleka kwe-micronutrient ehambisana nakho kunzima ukuzithethelela. Ama-FMD ayimithetho yokudla eklanyelwe ngokwemithi ephansi kakhulu ngamakholori (okungukuthi, ngokuvamile phakathi kwe-300 ne-1,100kcal ngosuku), ushukela namaprotheni aphinda avuselele imiphumela eminingi yokuzila ukudla kwamanzi kuphela kodwa ngokuhambisana nesiguli okungcono kanye nokunciphisa ingozi yokudla okunempilo22,61,62, 3. Ngesikhathi se-FMD, iziguli ngokuvamile zithola amanani angavinjelwe amanzi, izingxenye ezincane, ezilinganiselwe zemifino yemifino, amasobho, amajusi, ama-nut bars, nama-herbal teas, kanye nezithako ze-micronutrients. Esifundweni somtholampilo semijikelezo yenyanga ye-5 ye-FMD yezinsuku ezingu-1 ezifundweni ezinempilo ngokuvamile, ukudla kwakubekezelelwe kahle futhi kuncishiswe isiqu kanye namafutha omzimba, umfutho wegazi kanye namazinga e-IGF62. Ezivivinyweni zomtholampilo ze-oncological ezedlule neziqhubekayo, ukuzila ukudla noma ama-FMD ngokuvamile aye anikezwa njalo emavikini angu-3�4, isibonelo, ngokuhambisana nemithi yokwelapha ngamakhemikhali, futhi ubude bawo busukela phakathi ko-1 no-5 izinsuku52,53,58,61,63�68. . Okubalulekile, azikho izehlakalo ezimbi kakhulu (izinga G3 noma ngaphezulu, ngokuya Ngemibandela Yegama Elivamile Yezehlakalo Ezimbi) ezibikwe kulolu cwaningo52,53,58,61.

Izidlo ze-Ketogenic

Izidlo ze-Ketogenic (KDs) ziyizinhlobo zokudla ezinekhalori evamile, amafutha aphezulu kanye ne-low-carbohydrate content69,70. Ku-KD yakudala, isilinganiso phakathi kwesisindo samafutha nesisindo esihlanganisiwe se-carbohydrate namaprotheni ngu-4:1. Okuqaphelekayo, ama-FMD nawo ane-ketogenic ngoba anokuqukethwe kwamafutha amaningi futhi anamandla okwenza ukuphakama okukhulu (?0.5mmol ngelitha) emazingeni emizimba ye-ketone ejikelezayo. Kubantu, i-KD nayo inganciphisa i-IGF1 kanye namazinga e-insulin (ngaphezu kuka-20% kusuka kumanani ayisisekelo), nakuba le miphumela ithintwa amazinga nezinhlobo zama-carbohydrates namaprotheni ekudleni71. Ama-KD angawehlisa amazinga kashukela egazini, kodwa ngokuvamile ahlala ebangeni elivamile (okungukuthi,>4.4mmol ngelitha)71.

Ngokuphawulekayo, ama-KD angase asebenze kahle ekuvimbeleni ukwanda kwe-glucose ne-insulin okwenzeka ngokuvamile ngokuphendula ama-PI3K inhibitors, okwakuhlongozwe ukuthi anciphise ukusebenza kwawo kahle72. Ngokwesiko, ama-KD asetshenziselwe ukwelapha isithuthwane esingalapheki, ikakhulukazi ezinganeni69. Kumamodeli wamagundane, ama-KD adala imiphumela yokulwa nomdlavuza, ikakhulukazi ku-glioblastoma70,72�86. Ucwaningo lwezokwelapha lubonisa ukuthi cishe ama-KD awanawo umsebenzi wokwelapha omkhulu lapho esetshenziswa njengezisebenzi ezingashadile ezigulini ezinomdlavuza futhi aphakamisa ukuthi izinzuzo ezingaba khona zalokhu kudla kufanele zifunwe kuhlanganiswe nezinye izindlela, ezifana nokwelashwa ngamakhemikhali, i-radiotherapy, ukwelashwa kwe-antiangiogenic, i-PI3K inhibitors. futhi Ama-FMDs72,73.

Ama-KD abikwa ukuthi anemiphumela ye-neuroprotective ku-peripheral nerves naku-hippocampus87,88. Kodwa-ke, kusazotholakala ukuthi ingabe ama-KD nawo anemiphumela yokuzala efana nokuzila ukudla noma ama-FMD (Ibhokisi 1) nokuthi ingabe ama-KD nawo angasetshenziswa yini ukuvikela izilwane ezincelisayo eziphilayo ebuthizeni be-chemotherapy. Ngokuphawulekayo, imiphumela evuselelayo yokuzila ukudla noma ama-FMD ibonakala ikhuliswa ngokushintshwa kwemodi yokuphendula indlala, okubandakanya ukuwohloka kwezingxenye zamangqamuzana nokufa kwamangqamuzana amaningi, kanye nesikhathi sokudla kabusha, lapho amangqamuzana nezicubu zihamba khona. ukwakhiwa kabusha22. Ngenxa yokuthi ama-KD awaphoqi ukungena kwimodi yokulamba, ungakhuthazi ukuwohloka okukhulu kwezingxenye ze-intracellular kanye nezicubu futhi azibandakanyi isikhathi sokuncelisa, cishe akunakwenzeka ukuthi kubangele uhlobo lokuvuselela okuhlelekile okubonwa ngesikhathi sokuncelisa i-FMD.

Umkhawulo Wekhalori

Nakuba ukuvinjelwa kwekhalori okungapheli (CR) nokudla okuntula kuma-amino acid athile kuhluke kakhulu ekuzileni ukudla ngezikhathi ezithile, babelana ngokuzila ukudla kanye nama-FMD ngokukhawulelwa okukhethekile noma okuncane kwezakhamzimba, futhi kunemiphumela ye-anticancer81,89�112. I-CR ngokuvamile ihilela ukunciphisa okungama-20�30% okungapheli kokuthatha amandla kusukela enkambeni yekhalori evamile engavumela umuntu ukuthi alondoloze isisindo esivamile113,114. Isebenza kahle kakhulu ekwehliseni izici eziyingozi zenhliziyo nemithambo yegazi kanye nesigameko somdlavuza ezinto eziphilayo eziyimodeli, okuhlanganisa nezimpungushe108,109,114.

Kodwa-ke, i-CR ingabangela imiphumela emibi, njengokushintsha kokubukeka komzimba, ukwanda kokuzwela kwamakhaza, ukunciphisa amandla, ukungahambi kahle kokuya esikhathini, ukungabi nabantwana, ukulahlekelwa i-libido, i-osteoporosis, ukuphulukiswa kwesilonda kancane, ukudla ngokweqile, ukucasuka, nokucindezeleka. Ezigulini ezinomdlavuza, kunokukhathazeka okukhulu ngokuthi kungase kubhebhethekise ukungondleki kahle nokuthi kuzodala ukulahlekelwa ngokweqile komzimba onomzimba omncane18,113�116. I-CR inciphisa amazinga eglucose ezila ukudla, nakuba ehlala ngaphakathi kwebanga elijwayelekile114. Kubantu, i-CR engapheli ayithinti amazinga e-IGF1 ngaphandle kokuthi umkhawulo omaphakathi wamaprotheni nawo uqaliswe117.

Ucwaningo lubonisa ukuthi ngokunciphisa ukusayina kwe-mTORC1 kumaseli e-Paneth, i-CR ikhulisa umsebenzi wabo we-stem cell futhi iphinde ivikele ukugcinwa kwamangqamuzana e-intestinal stem emonakalweni we-DNA118,119, kodwa akwaziwa ukuthi imiphumela ye-pro-regenerative kwezinye izitho nayo ikhishwe yi-CR. Ngakho-ke, idatha etholakalayo iphakamisa ukuthi ukuzila ukudla kanye nama-FMD kudala iphrofayili ye-metabolic, yokuvuselela kanye neyokuvikela ehlukile futhi cishe enamandla kunaleyo ekhishwe yi-KD noma i-CR.

Ukuzila ukudla nama-FMD Ekwelapheni: Imiphumela kuma-hormone namazinga e-metabolite

Izinguquko eziningi emazingeni ama-hormone ajikelezayo nama-metabolites avame ukubonwa ekuphenduleni ukuzila ukudla anamandla okusebenzisa imiphumela ye-antitumour (okungukuthi, amazinga ancishisiwe e-glucose, i-IGF1, i-insulin ne-leptin kanye namazinga akhulayo e-adiponectin) i-23,120,121 kanye/ noma ukukhokhela ukuvikelwa kwezicubu ezinempilo emiphumeleni emibi (okungukuthi, amazinga ancishisiwe e-IGF1 kanye ne-glucose). Ngenxa yokuthi imizimba ye-ketone ingavimbela i-histone deacetylases (i-HDACs), ukwanda okubangelwa ukuzila kwemizimba ye-ketone kungasiza ekubambeni ukukhula kwesimila futhi kukhuthaze ukuhlukana ngokusebenzisa izindlela ze-epigenetic122.

Kodwa-ke, i-ketone body acetoacetate ikhonjiswe ukuthi isheshisa, esikhundleni sokunciphisa, ukukhula kwezimila ezithile, njenge-melanomas ene-BRAF123 eguquliwe. Lezo zinguquko ezinobufakazi obunamandla kakhulu bendima emiphumeleni enenzuzo yokuzila ukudla kanye nama-FMD ngokumelene nomdlavuza ukuncipha kwamazinga e-IGF1 kanye ne-glucose. Ezingeni lamangqamuzana, ukuzila ukudla noma i-FMD kunciphisa ukugeleza kokusayina kwe-intracellular okuhlanganisa i-IGF1R�AKT�mTOR�S6K nokusayina kwe-cAMP�PKA, kwandisa i-autophagy, kusiza amaseli avamile ukuthi amelane nengcindezi futhi kukhuthaze ukungatheleleki kwe-anticancer25,29,56,124

Ukumelana Nokucindezeleka Okuhlukile: Ukwandisa Ukubekezelelana Kwe-Chemotherapy

Amanye ama-orthologues we-yeast oncogene, njenge-Ras ne-Sch9 (i-orthologue esebenzayo ye-mammalian S6K), ayakwazi ukwehlisa ukumelana nokucindezeleka ezintweni eziphilayo eziyimodeli27,28. Ngaphezu kwalokho, ukuguqulwa kwezakhi zofuzo okwenza kusebenze i-IGF1R, i-RAS, i-PI3KCA noma i-AKT, noma eyenza i-PTEN isebenze, ikhona kumdlavuza wabantu abaningi10. Ngokuhlangene, lokhu kuholele kumbono wokuthi indlala izodala imiphumela ephambene kumdlavuza uma uqhathaniswa namaseli ajwayelekile ngokuya nekhono lawo lokumelana nezingcindezi zamaseli, okuhlanganisa ne-chemotherapeutics. Ngamanye amazwi, indlala ingaholela umehluko ukumelana nokucindezeleka (DSR) phakathi kwamangqamuzana avamile nomdlavuza.

Ngokuvumelana ne-hypothesis ye-DSR, amangqamuzana avamile asabela endlaleni ngokunciphisa ukusabalala okuhlobene ne-ribosome biogenesis kanye/noma izakhi zofuzo zokuhlanganisa, okuphoqa amangqamuzana ukuthi angene kumodi yokuzinakekela futhi awavikele emonakalweni obangelwa ukwelapha ngamakhemikhali, i-radiotherapy nezinye izinto ezinobuthi. Ngokuphambene, kumangqamuzana omdlavuza, le ndlela yokuzinakekela ivinjelwa ngezinguquko ze-oncogenic, ezibangela ukuvinjelwa okuyisisekelo kwezindlela zokuphendula ukucindezeleka12 (Fig. 1). Ngokuhambisana nemodeli ye-DSR, indlala yesikhashana noma ukususwa kwe-proto-oncogene ozakwabo (okungukuthi, i-Sch9 noma kokubili i-Sch9 kanye ne-Ras2) ikhuphule ukuvikeleka kwe-Saccharomyces cerevisiae ekucindezelekeni kwe-oxidative noma izidakamizwa ze-chemotherapy ngokuphindwe kayi-100 uma kuqhathaniswa namaseli e-yeast aveza i-oncogene esebenzayo. uzakwabo Ras2val19.

Imiphumela efanayo yatholwa kumaseli ezilwane ezincelisayo: ukuchayeka kumithombo ye-glucose ephansi kuvikele amaseli egundane e-glia kubuthi obuvela ku-hydrogen peroxide noma i-cyclophosphamide (i-prooxidant chemotherapeutic) kodwa ayizange ivikele igundane, igundane ne-glioma yomuntu kanye nemigqa yeseli yomdlavuza we-neuroblastoma. Ngokuhambisana nalokhu okuphawuliwe, izinsuku eziyi-2 ukuzila ukudla kukhulisa ngempumelelo ukusinda kwamagundane aphathwe nge-etoposide ephezulu uma kuqhathaniswa namagundane angalindi futhi kwandisa ukusinda kwe-neuroblastoma. i-allograftbearing amagundane uma kuqhathaniswa namagundane angenasisimila angazileli12.

Ucwaningo olwalandela lwathola ukuthi ukusayinda okuncishisiwe kwe-IGF1 ekuphenduleni ukuzila kuvikela i-glia eyinhloko nama-neurons, kodwa hhayi amaseli e-glioma ne-neuroblastoma, kusukela ku-cyclophosphamide nakuma-pro-oxidative compounds futhi ivikela i-mouse embryonic fibroblasts ku-doxorubicin29. I-Liver IGF1-deficient (LID) amagundane, izilwane ezishintshashintshayo ezinemibandela yokususwa kofuzo lwe-Igf1 olunemibandela olubonisa ukuncishiswa okungama-70&80% emazingeni e-IGF1 ajikelezayo (amazinga afana nalawo azuzwe ngokusheshisa kwamahora angama-72 kumagundane)29,125, avikelwe kuwo. kuhlolwe imishanguzo emithathu kwemine yokwelapha ngamakhemikhali, kuhlanganise ne-doxorubicin.

Ucwaningo lwe-Histology lubonise izimpawu ze-doxorubicin-induced cardiac myopathy kumagundane okulawula ane-doxorubicin kuphela kodwa hhayi kumagundane e-LID. Ekuhlolweni kwezilwane ezithwala i-melanoma eziphathwe nge-doxorubicin, akukho mehluko mayelana nokuqhubeka kwesifo phakathi kokulawula kanye namagundane e-LID wabonwa, okubonisa ukuthi amangqamuzana omdlavuza awavikelekile ku-chemotherapy ngamazinga ancishisiwe e-IGF1. Kodwa-ke, futhi, amagundane ane-LID ane-tumor abonise inzuzo emangalisayo yokusinda uma kuqhathaniswa nezilwane ezilawulayo ngenxa yekhono lazo lokumelana nobuthi be-doxorubicin29. Ngakho, jikelele, le miphumela iqinisekisile ukuthi i-IGF1 downregulation iyindlela eyinhloko lapho ukuzila kwandisa ukubekezelelana kwe-chemotherapy.

Womabili ama-dexamethasone kanye ne-mTOR inhibitors asetshenziswa kabanzi ekwelapheni umdlavuza, ngenxa yokuthi ayasebenza njenge-anti-emetics kanye anti-allergies (okungukuthi, i-corticosteroids) noma eyabo i-antitumour izakhiwo (okungukuthi, i-corticosteroids ne-mTOR inhibitors). Kodwa-ke, omunye wemiphumela yabo engathandeki eyinhloko futhi evamise ukukhawulela umthamo iwukuba i-hyperglycemia. Ngokuvumelana nombono wokwenyusa i-glucose�cAMP� PKA ukusayina kunciphisa ukumelana nobuthi bezidakamizwa ze-chemotherapeutic12,26,126, zombili i-dexamethasone futhi I-rapamycin inyusa ubuthi be-doxorubicin kuma-cardiomyocytes egundane namagundane26. Kuyathakazelisa ukuthi kwakungenzeka ukubuyisela emuva ubuthi obunjalo ngokunciphisa amazinga eglucose ejikelezayo ngokuzila ukudla noma ngemijovo ye-insulin26.

Lokhu kungenelela kunciphisa umsebenzi we-PKA ngenkathi kukhulisa umsebenzi we-AMPK bese ngokwenza i-EGR1 isebenze, okubonisa ukuthi ukusayinda kwe-cAMP� PKA kulamula i-DSR ebangelwa ukuzila nge-EGR1 (ref. 26). I-EGR1 iphinde ikhuthaze ukuvezwa kwama-peptides e-cardioprotective, njenge-atrial natriuretic peptide (ANP) kanye ne-B-type natriuretic peptide (BNP) ezicutshini zenhliziyo, okunomthelela ekwandeni kwe-doxorubicin. Ngaphezu kwalokho, ukuzila ukudla kanye/noma i-FMD kungase kuvikele amagundane ku-doxorubicin-induced cardiomyopathy ngokuthuthukisa i-autophagy, engakhuthaza impilo yeselula ngokunciphisa ukukhiqizwa kwezinhlobo ze-oksijini esebenzayo (ROS) ngokuqeda i-mitochondria engasebenzi kanye nokususwa kwe-aggregate enobuthi.

Ngaphezu kokunciphisa ubuthi obubangelwa ngamakhemikhali emangqamuzaneni nokwandisa ukusinda kwamagundane alashwe ngamakhemikhali, imijikelezo yokuzila ukudla yenza ukuvuselelwa komnkantsha wethambo futhi kuvimbele ukuzivikela komzimba okubangelwa i-cyclophosphamide ngendlela ehlobene ne-PKA kanye ne-IGF1 ehlobene25. Ngakho-ke, imiphumela ephoqelekile ye-preclinical ibonisa amandla okuzila ukudla kanye nama-FMD ukwandisa ukubekezelelana kwe-chemotherapy nokugwema imiphumela emibi kakhulu. Ngenxa yokuthi idatha yokuqala yomtholampilo inikeza ukusekelwa okwengeziwe kulokhu okungenzeka, lezi zifundo zangaphambi komtholampilo zakha isizathu esiqinile sokuhlola ama-FMD ezivivinyweni zomtholampilo ezingahleliwe nama-TEAE njengephuzu lokugcina eliyinhloko.

Ukuzwela Okuhlukile Kokucindezeleka: Ukwandisa Ukufa Kwamangqamuzana Omdlavuza

Uma isetshenziswe yodwa, ukungenelela okuningi kokudla, okuhlanganisa ukuzila ukudla kanye nama-FMD, kunemiphumela elinganiselwe ngokumelene nokuqhubeka komdlavuza. Ngokusho kwe-different stress sensitization (DSS) hypothesis, inhlanganisela yokuzila ukudla noma ama-FMD anokwelashwa kwesibili kuthembisa kakhulu11,12. Le nkolelo-mbono ibikezela ukuthi, ngenkathi amangqamuzana omdlavuza ekwazi ukuzivumelanisa nomoya-mpilo olinganiselwe kanye nokugxila kwezakhi, izinhlobo eziningi zamangqamuzana omdlavuza azikwazi ukwenza izinguquko ezingavumela ukusinda endaweni engenazo izakhi kanye nobuthi ekhiqizwa inhlanganisela yokuzila ukudla kanye ne-chemotherapy. , Ngokwesibonelo. Ukuhlolwa kwasekuqaleni komdlavuza webele, i-melanoma futhi amaseli e-glioma athole ukwanda okuyindida ekukhulumeni kwezakhi zofuzo ezihambisana nokwanda noma i-ribosome biogenesis kanye nezakhi zofuzo zokuhlangana ekuphenduleni ukuzila ukudla11,12. Izinguquko ezinjalo zihambisane nokusebenza okungalindelekile kwe-AKT ne-S6K, ukuthambekela kokukhiqiza umonakalo we-ROS ne-DNA kanye ukuzwela emithini elimaza i-DNA (nge-DSS)11.

Sibheka impendulo enjalo engalungile yamangqamuzana omdlavuza ezimweni ezishintshiwe ezihlanganisa ukunciphisa i-IGF1 kanye namazinga e-glucose okubangelwa ukuzila ukudla noma ama-FMD njengendlela eyinhloko engaphansi i-antitumour izakhiwo zalokhu kungenelela kokudla kanye nokusebenziseka kwazo okungase kube usizo ekuhlukaniseni imiphumela yokwelashwa kwe-antiticancer kumaseli avamile ngokumelene namaseli ayingozi11,12 (Fig. 1). Ngokuvumelana ne-DSS hypothesis, imijikelezo yezikhathi zokuzila ukudla noma yama-FMD yanele ukunciphisa ukukhula kwezinhlobo eziningi ze-FMD. isisu amaseli, asukela emigqeni yamaseli e-tumor aqinile kuya kumaseli e-lymphoid leukemia, kugundane futhi, okubaluleke kakhulu, ukuqwashisa amangqamuzana omdlavuza kuma-chemotherapeutics, radiotherapy kanye ne-tyrosine kinase inhibitors (TKIs) 11,17,22,25,50,54�57,59,60,124,127,128, XNUMX.

Ngokunciphisa ukutholakala kwe-glucose nokwandisa i-fatty acid ?-oxidation, ukuzila ukudla noma ama-FMD kungabuye kukhuthaze ukushintshwa kusuka ku-aerobic glycolysis (umphumela we-Warburg) kuya ku-mitochondrial oxidative phosphorylation kumangqamuzana omdlavuza, okudingekayo ukuze kugcinwe ukukhula kwamangqamuzana omdlavuza endaweni empofu kakhulu enomsoco50 (Umdwebo 2). Lokhu kushintsha kuholela ekwandeni kokukhiqizwa kwe-ROS11 ngenxa yokwanda komsebenzi wokuphefumula we-mitochondrial futhi kungase kuhlanganise nokuncipha kwamandla e-redox eselula ngenxa yokuncipha kokuhlangana kwe-glutathione kusuka ku-glycolysis kanye ne-pentose phosphate pathway50. Umthelela ohlangene we-ROS augmentation nokunciphisa ukuvikelwa kwe-antioxidant kukhulisa ukucindezeleka kwe-oxidative kumaseli omdlavuza futhi kukhulise umsebenzi we-chemotherapeutics. Ngokuphawulekayo, ngenxa yokuthi umsebenzi ophezulu we-glycolytic oboniswa ukukhiqizwa kwe-lactate ephezulu ubikezela ulaka kanye nokuthambekela kwe-metastatic ezinhlotsheni ezimbalwa zomdlavuza129, imiphumela ye-anti-Warburg yokuzila ukudla noma i-FMD inamandla okusebenza ngempumelelo ikakhulukazi ngokumelene nomdlavuza we-metastatic.

Ngaphandle koshintsho kumetabolism, ukuzila ukudla noma ama-FMD afaka ezinye izinguquko ezingakhuthaza i-DSS kumaseli omdlavuza we-pancreatic. Ukuzila ukudla kwandisa amazinga okuveza ukulinganisa I-nucleoside transporter 1 (ENT1), i-transporter ye-gemcitabine yonkana ulwelwesi lwe-plasma, okuholela ekusebenzeni okuthuthukisiwe kwalesi sidakamizwa128. Kumangqamuzana omdlavuza webele, ukuzila ukudla kubangela ukuguqulwa kwe-SUMO2-mediated kanye/noma i-SUMO3-mediated ye-REV1, i-DNA polymerase kanye ne-p53-binding protein127. Lokhu kuguqulwa kunciphisa ikhono le-REV1 lokuvimbela i-p53, okuholela ekwandeni kokulotshwa kwe-p53-mediated yezakhi zofuzo ze-pro-apoptotic futhi, ekugcineni, ekubulaweni kweseli lomdlavuza (Fig. 2). Ukuzila ukudla futhi kukhulisa ikhono lama-TKI alawulwa ngokuvamile okumisa ukukhula kwamangqamuzana omdlavuza kanye/noma ukufa ngokuqinisa ukuvinjelwa kokusayina kwe-MAPK futhi, ngaleyo ndlela, kuvimbele ukubonakaliswa kofuzo okuncike ku-E2F okulotshiweyo kodwa futhi ngokunciphisa ukumuncwa kwe-glucose17,54.

Ekugcineni, ukuzila ukudla kungakhuphula i-leptin receptor kanye nomfula wayo ongezansi ukusayina nge-protein PR/SET domain 1 (PRDM1) futhi ngaleyo ndlela ivimbele ukuqaliswa futhi ihlehlise ukuqhubeka kwe-B cell kanye ne-T cell acute lymphoblastic i-leukemia (BONKE), kodwa hhayi we-myeloid ebuhlungu i-leukemia (AML)55. Kuyathakazelisa ukuthi ucwaningo oluzimele lubonise ukuthi ama-precursors e-B cell abonisa isimo sokuvinjelwa okungapheli ku-glucose kanye nezinsiza zamandla ezibekwe yizici zokubhaliwe ze-PAX5 ne-IKZF1 (ref. 130). Ukuguqulwa kofuzo okufaka ikhodi kulawa maprotheni amabili, akhona kuzimo ezingaphezu kuka-80% we-pre-B cell ALL, aboniswe ukwandisa ukumukeka kwe-glucose namazinga e-ATP. Kodwa-ke, ukuhlanganisa kabusha i-PAX5 ne-IKZF1 kumaseli e-preB-ALL kuholele enkingeni yamandla kanye nokuncipha kweseli. Uma kuthathwe kanye nocwaningo lwangaphambilini, lo msebenzi ubonisa ukuthi BONKE bangase bazwele ekuvinjweni kwezakhi kanye namandla okubekwe ngokuzila ukudla, okungenzeka bamele ikhandidethi elihle lomtholampilo ukuze kuhlolwe ukusebenza kokuzila ukudla noma i-FMD.

Ngokuphawulekayo, kungenzeka ukuthi izinhlobo eziningi zamangqamuzana omdlavuza, okuhlanganisa i-AML29, zingathola ukumelana ngokugwema izinguquko ze-metabolic ezibekwe ngokuzila ukudla noma ama-FMD, okungenzeka ukuthi kuphinde kukhuliswe ukuhlukahluka kwe-metabolic eveza izinhlobo eziningi zomdlavuza129. Ngakho-ke, umgomo omkhulu wesikhathi esizayo esiseduze kuzoba ukuhlonza izinhlobo zomdlavuza ezitholakala kalula kulezi zinhlobo zokudla ngokusebenzisa ama-biomarker. Ngakolunye uhlangothi, uma kuhlanganiswa nemithi evamile, ukuzila ukudla noma ama-FMD akuvamile ukuba kubangele ukutholakala kokumelana kumamodeli egundane lomdlavuza, futhi ukumelana nokuzila ukudla okuhlangene ne-chemotherapy nakho akuvamile ezifundweni ze-in vitro, ezigcizelela ukubaluleka kokuhlonza izindlela zokwelapha ukuthi, uma kuhlanganiswa nama-FMD, kubangela imiphumela enobuthi enamandla ngokumelene namaseli omdlavuza anobuthi obuncane kumaseli avamile kanye nezicubu11,17,50,55�57,59,124.

I-Antitumour Immunity Enhancement Ngokuzila ukudla noma i-FMD

Idatha yakamuva iphakamisa ukuthi ukuzila ukudla noma ama-FMD ngokwawo, futhi ngokwezinga elikhulu uma kuhlanganiswa nokwelashwa ngamakhemikhali, kubangela ukwanda kwama-lymphoid progenitors futhi akhuthaze. isisu ukuhlasela kwamasosha omzimba ngezindlela ezahlukene25,56,60,124. I-FMD inciphise ukubonakaliswa kwe-HO1, iphrotheni enikeza ukuvikeleka emonakalweni we-oxidative kanye ne-apoptosis, kumaseli omdlavuza ku-vivo kodwa isisho se-HO1 esimisiwe kumaseli avamile124,131. Ukwehliswa kwe-HO1 kumaseli omdlavuza kulamula i-chemosensitization eyenziwe yi-FMD ngokukhulisa i-cytotoxicity encike ku-CD8 + i-lymphocyte-infiltrating lymphocyte-dependent, engase ihambisane nokwehliswa kokulawulwa kwamaseli T okulawula124 (Fig. 2). Olunye ucwaningo, oluqinisekisa ikhono lokuzila ukudla noma ama-FMD kanye nama-CR mimetics ukuthuthukisa i-anticancer immunosurveillance, lisikisela ukuthi imiphumela ye-anticancer yokuzila ukudla noma ama-FMD ingase isebenze ku-autophagy abanekhono, kodwa hhayi i-autophagy-deficient, cancers56. Ekugcineni, ucwaningo lwakamuva lokunye ukuzila ukudla amaviki ama-2 kumodeli yomdlavuza wekoloni legundane lubonise ukuthi, ngokwenza kusebenze i-autophagy kumaseli omdlavuza, ukuzila ukudla kwehlisa isisho se-CD73 futhi ngenxa yalokho kunciphisa ukukhiqizwa kwe-immunosuppressive adenosine ngamaseli omdlavuza60. Ekugcineni, ukwehla kwe-CD73 ngokuzila ukudla kwaboniswa ukuvimbela ukushintshwa kwe-macrophage ku-M2 immunosuppressive phenotype (Fig. 2). Ngokwesisekelo salezi zifundo, kuyathandeka ukuqagela ukuthi ama-FMD angaba usizo ikakhulukazi esikhundleni noma ahlanganiswe ne-immune checkpoint inhibitors132, imigomo yomdlavuza noma ezinye izidakamizwa ezikhuthazayo. i-antitumour ukungatheleleki, okuhlanganisa nemithi ethile evamile ye-chemotherapeutics133.

Izidlo ze-Anticancer kumamodeli wegundane

Sekukonke, imiphumela yezifundo zangaphambi komtholampilo zokuzila ukudla noma ama-FMD kumamodeli omdlavuza wezilwane, okubandakanya amamodeli omdlavuza we-metastatic (Ithebula 2), ibonisa ukuthi ukuzila ukudla ngezikhathi ezithile noma ama-FMD afinyelela imiphumela ye-pleiotropic anticancer futhi aqinise umsebenzi we-chemotherapeutics kanye ne-TKI ngenkathi esebenzisa imiphumela yokuzivikela neyokuvuselela. ezithweni eziningi22,25. Ukuzuza imiphumela efanayo ngaphandle kokuzila ukudla kanye/noma ama-FMD kungadinga kuqala ukukhonjwa bese kuba ukusetshenziswa kwezidakamizwa eziningi ezisebenzayo, ezibizayo nezivame ukuba nobuthi futhi cishe kungaba ngaphandle kwenzuzo yokuheha ukuvikelwa kweseli okunempilo. Kuyaphawuleka ukuthi okungenani ezifundweni ezimbili ukuzila ukudla okuhlanganiswe nokwelashwa ngamakhemikhali kubonakale kuwukuphela kokungenelela okukwazi ukufeza ukwehla okuphelele kwesimila noma ukusinda isikhathi eside engxenyeni engaguquki yezilwane ezilashwa11,59.

Ama-KD Angamahlalakhona nawo akhombisa a isisu umphumela wokulibazisa ukukhula uma usetshenziswa njenge-monotherapy, ikakhulukazi kumamodeli wamagundane omdlavuza wobuchopho77,78,80�82,84,134. Ama-gliomas kumagundane agcinwe ku-KD engapheli anciphise ukubonakaliswa kwe-hypoxia marker carbonic anhydrase 9 kanye ne-hypoxia-inducible factor 1?, ukuncipha kokwenziwa kusebenze kwe-nuclear factor-?B kanye nokuncipha kophawu lwe-vascular (okungukuthi, i-vascular endothelial growth factor receptor 2, i-matrix metalloproteinase 2 kanye ne-vimentin)86. Kumodeli yegundane le-intracranial ye-glioma, amagundane aphakela i-KD ebonisiwe anda isimila-reactive izimpendulo zokuzivikela ezizalwa nazo neziguquguqukayo ezazilamulwa ngokuyinhloko ngamaseli e-CD8+ T79. Ama-KD aboniswe ukuthuthukisa umsebenzi we-carboplatin, i-cyclophosphamide kanye ne-radiotherapy ku-glioma, umdlavuza wamaphaphu. futhi amamodeli egundane le-neuroblastoma73�75,135. Ngaphezu kwalokho, ucwaningo lwakamuva lubonisa ukuthi i-KD ingaba wusizo kakhulu uma ihlanganiswa ne-PI3K inhibitors72. Ngokuvimba i-insulin ukusayinaLawa ma-ejenti akhuthaza ukuwohloka kwe-glycogen esibindini futhi avimbele ukumuncwa kwe-glucose emisipha yamathambo, okuholela ekutheni kube nesikhashana. i-hyperglycemia kanye nokukhululwa kwe-insulin okunxephezela kumanyikwe (into eyaziwa ngokuthi "impendulo ye-insulin"). Ngokulandelayo, lokhu Phakamisa emazingeni e-insulin, angathatha isikhathi eside, ikakhulukazi ezigulini ezinokumelana ne-insulin, ivuselela i-PI3K�mTOR ukusayina in izimila, ngaleyo ndlela ikhawulela kakhulu inzuzo ye-PI3K inhibitors. I-KD iboniswe isebenza kahle kakhulu ekuvimbeleni impendulo ye-insulin ekuphenduleni le mithi kanye nokuthuthukisa ngokunamandla umsebenzi wayo wokulwa nomdlavuza kugundane. Ekugcineni, ngokusho kocwaningo kumodeli ye-cachexia ye-murine-induced cachexia (ama-MAC16 tumors), ama-KD angasiza ekuvimbeleni ukulahlekelwa kwamafutha kanye nomzimba ongewona amafutha ezigulini ezinomdlavuza85.

I-CR yehlise i-tumorigenesis kumamodeli womdlavuza wegundane wofuzo, amamodeli wamagundane ane-tumorigenesis ezenzakalelayo kanye namamodeli amagundane omdlavuza, kanye nasezinkawini91,92,97,98,101,102,104�106,108,109,136�138. Ngokuphambene, ucwaningo lwathola ukuthi i-CR kusukela eminyakeni ephakathi empeleni yandisa izehlakalo ze-plasma cell neoplasms ku-C57Bl/6 mice139. Kodwa-ke, ocwaningweni olufanayo, i-CR iphinde yelula isikhathi sokuphila esiphezulu cishe ngo-15%, futhi ukwanda okuphawuliwe kwezigameko zomdlavuza kubangelwa ukukhula okude kwamagundane athola i-CR, iminyaka lapho okuzala isimila amagundane athola i-CR afile kanye nephesenti le okuzala isimila amagundane athola i-CR ashona. Ngakho-ke, ababhali baphetha ngokuthi i-CR cishe ibambezela ukukhuthazwa kanye / noma ukuqhubeka komdlavuza we-lymphoid okhona. Ukuhlaziywa kwe-meta eqhathanisa i-CR engapheli kanye ne-CR enezikhawu mayelana nekhono labo lokuvimbela umdlavuza kumagundane kuphethe ngokuthi i-CR yezikhawu iphumelela kakhulu kumamodeli wamagundane akhiwe ngofuzo, kodwa ayisebenzi kangako kumamodeli wamagundane akhangwe ngamakhemikhali90. I-CR iboniswe ukuthi ihamba kancane isisu ukukhula kanye/noma ukwandisa ukuphila kwamagundane kumamodeli egundane omdlavuza, okuhlanganisa umdlavuza we-ovarian kanye ne-pancreatic140,94 kanye ne-neuroblastoma81.

Okubalulekile, i-CR ithuthukise umsebenzi wokwelashwa kwe-anticancer kumamodeli womdlavuza amaningana, okuhlanganisa umsebenzi we-antiIGF1R antibody (ganitumab) ngokumelene nomdlavuza we-prostate141, i-cyclophosphamide ngokumelene ne-neuroblastoma cells135 kanye nokuvinjelwa kwe-autophagy kuma-xenografts we-HRAS-G12V transformed immortal baby mouse cells100lid. Nokho, i-CR noma i-KD ehlanganiswe nemithi yokwelapha elwa nomdlavuza ibonakala ingasebenzi kahle kunokuzila ukudla. Ucwaningo lwegundane lwathola ukuthi, ngokungafani nokuzila ukudla kuphela, i-CR iyodwa ayikwazanga ukunciphisa ukukhula kwamagundane e-GL26 akhula ngaphansi kwesikhumba nokuthi, futhi, ngokungafani nokuzila ukudla kwesikhathi esifushane, i-CR ayizange ikhulise umsebenzi we-cisplatin ngokumelene nesifuba se-4T1 esingaphansi. izimila51. Ocwaningweni olufanayo, ukuzila ukudla kuphinde kwabonakala kusebenza kakhulu kune-CR kanye ne-KD ekwandiseni ukubekezelelana kwe-doxorubicin51. Nakuba ukuzila ukudla noma i-FMD, i-CR kanye ne-KD kungenzeka kusebenze futhi kushintshe ukugqagqana ukusayina izindlela, ukuzila ukudla noma i-FMD cishe ithinta izindlela ezinjalo ngendlela enzima kakhulu phakathi nesigaba esinzima kakhulu sesikhathi esiphezulu sezinsuku ezimbalwa.

Isigaba refeeding kungaba ke umusa ukululama kwe-homeostasis yayo yonke into ephilayo kodwa futhi kusebenze futhi kuqinise izindlela ezingakhuthaza ukuqashelwa nokususwa kwe isisu futhi ukhiqize kabusha amaseli anempilo. I-CR kanye ne-KD ukungenelela okungapheli okukwazi ukucindezela ngokusesilinganisweni kuphela indlela yokuzwa izakhi, ngokunokwenzeka ngaphandle kokufinyelela imingcele ethile edingekayo ukuze kuthuthukiswe imiphumela yezidakamizwa ezilwa nomdlavuza, kuyilapho kubeka umthwalo omkhulu futhi ngokuvamile ukuncipha kwesisindo okuqhubekayo. I-CR kanye ne-KD njengemithi yokudla okungapheli ezigulini ezinomdlavuza kunzima ukuyisebenzisa futhi ingase ibe nezingozi zempilo. I-CR ingase iholele ekulahlekelweni okukhulu kwesisindo somzimba omncane kanye nokunciphisa amahomoni e-steroid kanye nomsebenzi wokuzivikela omzimba okungenzeka142. Ama-KD Angalapheki nawo ahlotshaniswa nemiphumela engemihle efanayo nakuba engemibi kangako143. Ngakho-ke, ukuzila ukudla ngezikhathi ezithile kanye nemijikelezo ye-FMD ehlala ngaphansi kwezinsuku ze-5 ezisetshenziswa kanye nemithi ejwayelekile inamandla amakhulu okuthuthukisa ukwelashwa komdlavuza ngenkathi kunciphisa imiphumela yayo emibi. Ngokuphawulekayo, kuzobaluleka ukufunda umphumela wokuhlanganiswa kwama-FMD ngezikhathi ezithile, ama-KD angapheli futhi izindlela zokwelapha ezijwayelekile, ikakhulukazi ezokwelashwa komdlavuza onamandla njenge-glioma.

Ukuzila ukudla kanye nama-FMD ku-Cancer Prevention

Izifundo ze-Epidemiological kanye nezifundo ezilwaneni, kuhlanganise nezinkawu108,109,144, kanye nabantu basekela umbono wokuthi i-CR engapheli nokuzila ukudla ngezikhathi ezithile kanye/noma i-FMD ingaba nemiphumela yokuvimbela umdlavuza kubantu. Noma kunjalo, i-CR angeke ikwazi ukuqaliswa kubantu abaningi ngenxa yezindaba zokuthobela imithetho kanye nemiphumela engemihle engaba khona115. Ngakho-ke, ngenkathi izincomo ezisekelwe ebufakazini zokudla okuthandayo (noma ukugwema) kanye nezincomo zendlela yokuphila yokunciphisa ingozi yomdlavuza ziyasungulwa6,8,9,15, inhloso manje ukukhomba futhi, ngokunokwenzeka, ukulinganisa ukubekezelelwa kahle, ngezikhathi ezithile. izimiso zokudla ezinemiphumela emibi ephansi noma engenazo futhi zihlole ukusebenza kahle kwazo kokuvimbela umdlavuza ezifundweni zomtholampilo.

Njengoba kuxoxiwe ngaphambili, imijikelezo ye-FMD ibangela ukwehla kokulawulwa kwe-IGF1 kanye ne-glucose kanye nokulawulwa kwe-IGFBP1 kanye nemizimba ye-ketone, okuyizinguquko ezifana nalezo ezibangelwa ukuzila ukudla ngokwazo futhi ziyizimpawu ze-biomarker zokuphendula okusheshayo22. Uma i-C57Bl/6 amagundane (avela ngokuzenzakalelayo izimila, ngokuyinhloko i-lymphomas, njengoba ikhula) yondliwa i-FMD enjalo ngezinsuku ze-4 kabili ngenyanga kusukela eminyakeni yobudala kanye nokudla kwe-ad libitum phakathi nesikhathi esiphakathi kwemijikelezo ye-FMD, izehlakalo ze-neoplasms zancishiswa kusukela cishe ku-70% kumagundane ekulawuleni. ukudla okulinganiselwa ku-40% kumagundane eqenjini le-FMD (ukunciphisa okuphelele kwama-43%)22. Ngaphezu kwalokho, i-FMD ihlehliswe ngezinyanga ezingaphezu kwe-3 ukwenzeka kokufa okuhlobene ne-neoplasm, futhi inani lezilwane ezinezilonda eziningi ezingavamile lalingaphezu kokuphindwe kathathu eqenjini lokulawula kunamagundane e-FMD, okubonisa ukuthi abaningi izimila kumagundane e-FMD ayenolaka oluncane noma enobuntu.

Ucwaningo lwangaphambilini lokunye ukuzila ukudla, olwenziwa kumagundane aneminyaka ephakathi isikhathi esiphelele sezinyanga ezi-4, luphinde lwathola ukuthi ukuzila ukudla kunciphisa ukwenzeka kwe-lymphoma, ukuletha kusuka ku-33% (kumagundane okulawula) kuya ku-0% (ngokuzila ukudla). izilwane)145, nakuba ngenxa yesikhathi esifushane socwaningo akwaziwa ukuthi lolu hlobo lokuzila luyakuvimbela yini noma lumane lubambezele isisu ukuqala. Ukwengeza, okunye ukuzila ukudla kosuku olulodwa kubeka izinsuku eziyi-15 ngenyanga zokuzila ukudla okuphelele kwamanzi kuphela, kanti ocwaningweni lwe-FMD oluchazwe ngenhla amagundane abekwe ekudleni okunikeza inani elilinganiselwe lokudla izinsuku eziyi-8 kuphela ngenyanga. Kubantu, imijikelezo engu-3 ye-FMD yezinsuku ezi-5 kanye ngenyanga yaboniswa ukunciphisa ukukhuluphala kwesisu kanye nezimpawu zokuvuvukala kanye ne-IGF1 kanye namazinga e-glucose ezifundweni ezinamazinga aphakeme alezi zimpawu62, okubonisa ukuthi ukusetshenziswa ngezikhathi ezithile kwe-FMD kungase kube khona. imiphumela yokuvimbela ehlobene nokukhuluphala noma ehlobene nokuvuvukala, kodwa nokunye, umdlavuza kubantu, njengoba kukhonjisiwe kuma-mice22.

Ngakho-ke, imiphumela ethembisayo yezifundo ze-preclinical ehlanganiswe nedatha yomtholampilo ngomphumela we-FMD ezicini eziyingozi okuhambisana nokuguga izifo, kuhlanganise nomdlavuza62, ziboleka ukusekelwa ezifundweni zesikhathi esizayo ezingahleliwe ze-FMD njengethuluzi eliphumelelayo lokuvimbela umdlavuza, kanye nezinye. okuhambisana nokuguga izimo ezingapheli, kubantu.

Ukusebenza Komtholampilo ku-Oncology

Izifundo ezine ezingenzeka zokuzila ukudla kanye nama-FMD ezigulini ezelashwa ngamakhemikhali zishicilelwe kusukela namuhla52,53,58,61. Ochungechungeni lweziguli eziyi-10 ezitholwe zinezinhlobo ezahlukene zomdlavuza, okuhlanganisa ibele, i-prostate, i-ovary, isibeletho, umdlavuza wamaphaphu kanye nomdlavuza we-esophageal, ezizila ukudla ngokuzithandela amahora angama-140 ngaphambi kanye/noma kuze kufike emahoreni angama-56 kulandela ukwelashwa ngamakhemikhali, akukho miphumela emibi edaliwe. ngokuzila ukudla ngokwako ngaphandle kwendlala nokukhanya kwabikwa58. Lezo ziguli (eziyisithupha) ezathola i-chemotherapy ngokuzila ukudla nangaphandle kwazo zibike ukunciphisa okukhulu kokukhathala, ubuthakathaka kanye nezenzakalo ezimbi zesisu ngesikhathi sokuzila ukudla. Ukwengeza, kulezo ziguli okungahlolwa kuzo ukuqhubeka komdlavuza, ukuzila ukudla akuzange kuvimbele ukuncishiswa okubangelwa ngamakhemikhali kumthamo wesimila noma kumakaki wesimila. Kolunye ucwaningo, abesifazane abangu-13 abane-HER2 (eyaziwa nangokuthi i-ERBB2) negative, umdlavuza webele wesigaba II/III abathola i-neo-adjuvant taxotere, i-adriamycin kanye ne-cyclophosphamide (TAC) yokwelapha ngamakhemikhali ayenziwe ngokungahleliwe ukuze asheshe (amanzi kuphela) amahora angu-24 ngaphambi nangemuva kokuqala ukwelashwa ngamakhemikhali noma ekudleni ngokweziqondiso ezijwayelekile52.

Ukuzila ukudla isikhathi esifushane kwakubekezelelwa kahle futhi kwanciphisa ukwehla kwezibalo ze-erythrocyte kanye ne-thrombocyte izinsuku ezingu-7 ngemva kokwelashwa ngamakhemikhali. Kuyathakazelisa ukuthi kulolu cwaningo, amazinga e-?-H2AX (umaka wokulimala kwe-DNA) anyuswe emizuzwini engu-30 ngemva kokwelashwa ngamakhemikhali ku-leukocyte ezigulini ezingazile kodwa hhayi ezigulini ezazizile ukudla. Ekwenyukeni komthamo wokuzila ukudla ezigulini ezelashwa nge-chemotherapy esekelwe ku-platinum, iziguli ezingama-20 (ezazilashelwa ikakhulukazi umdlavuza we-urothelial, ovarian noma webele) zahlelwa ngokungahleliwe ukuthi zizile ukudla amahora angama-24, angama-48 noma angama-72 (ahlukaniswe ngamahora angama-48 ngaphambi kokwelashwa ngamakhemikhali namahora angama-24 ngemuva kokwelashwa ngamakhemikhali. )53. Imibandela yokuba nokwenzeka (echazwa njengezifundo ezintathu noma ngaphezulu kweziyisithupha eqenjini ngalinye edla?200kcal ngosuku phakathi nesikhathi esisheshayo ngaphandle kobuthi obeqile) kwahlangatshezwana nayo. Ubuthi obuhlobene nokuzila ukudla babehlale bebangeni 2 noma ngaphansi, okuvame kakhulu ukukhathala, ikhanda elibuhlungu futhi isiyezi. Njengasocwaningweni olwedlule, ukulimala kwe-DNA okuncishisiwe (njengoba kutholwe i-comet assay) kuma-leukocyte avela ezifundweni ezizila ukudla okungenani amahora angu-48 (uma kuqhathaniswa nezihloko ezizila ukudla amahora angu-24 kuphela) nazo zingatholakala kulesi sivivinyo esincane. Ukwengeza, inkambiso engabalulekile eya ebangeni elingaphansi lesi-3 noma i-neutropenia yebanga lesi-4 ezigulini ezazizila ukudla amahora angama-48 nangama-72 uma kuqhathaniswa nalabo ababezila ukudla amahora angama-24 kuphela nayo yabhalwa.

Muva nje, ukuhlolwa komtholampilo kwe-crossover okungahleliwe kwenziwa ukuhlola imiphumela ye-FMD ngekhwalithi yokuphila kanye nemiphumela emibi ye-chemotherapy kungqikithi yeziguli ze-34 ezinomdlavuza webele noma we-ovarian61. I-FMD yayihlanganisa nsuku zonke Ukudla kwe-caloric engu-<400kcal, ngokuyinhloko ngamajusi nama-broth, aqala amahora angu-36�48 ngaphambi kokuqala kokwelashwa ngamakhemikhali futhi aqhubeke kuze kube amahora angu-24 ngemva kokuphela kokwelashwa ngamakhemikhali. Kulolu cwaningo, i-FMD ivimbele ukuncishiswa kwe-chemotherapy kwekhwalithi yokuphila futhi yanciphisa nokukhathala. Futhi, azikho izehlakalo ezimbi kakhulu ze-FMD ezibikiwe. Ezinye izivivinyo eziningi zomtholampilo zama-FMD ahlanganiswe ne-chemotherapy noma nezinye izinhlobo zokwelapha ezisebenzayo okwamanje ziyaqhubeka ezibhedlela zase-US naseYurophu, ikakhulukazi ezigulini ezitholwe zinomdlavuza webele noma wendlala yesinye63,65�68. Lezi kungaba yizifundo zomtholampilo zengalo eyodwa zokuhlola ukuphepha kwe-FMD nokuba nokwenzeka noma izifundo zomtholampilo ezingahleliwe ezigxile emphumeleni we-FMD ebuthi be-chemotherapy noma izinga lempilo yeziguli ngesikhathi sokwelashwa ngamakhemikhali ngokwawo. Sekukonke, lezi zifundo manje sezibhalise iziguli ezingaphezu kuka-300, futhi imiphumela yazo yokuqala kulindeleke ukuthi itholakale ngo-2019.

Izinselelo Emtholampilo

Ukutadisha ukuzila ukudla ngezikhathi ezithile noma ama-FMD ku-oncology akunakho ukukhathazeka, ikakhulukazi maqondana nokuthi kungenzeka ukuthi lolu hlobo lwemithi yokudla lungabangela ukungondleki, i-sarcopenia, futhi i-cachexia ezigulini ezilindelekile noma ezibuthakathaka (ngokwesibonelo, iziguli ezihlakulela i-anorexia ngenxa ye-chemotherapy) 18,19. Kodwa-ke, azikho izehlakalo zokuncipha okukhulu kwesisindo (ngaphezu kwebanga lesi-3) noma ukungondleki ezibikwe ocwaningweni lomtholampilo lokuzila ukudla okuhlanganiswe nokwelashwa ngamakhemikhali okushicilelwe njengamanje, futhi lezo ziguli ezake zaba nokuncipha kwesisindo ngesikhathi sokuzila ukudla ngokuvamile zasithola isisindo sazo ngaphambi kokuhlinzwa. umjikelezo olandelayo ngaphandle kokulimala okubonakalayo. Noma kunjalo, sincoma ukuthi ukuhlolwa kwe-anorexia ngezikhathi ezithile kanye nesimo sokudla okunempilo kusetshenziswa izindlela ezisezingeni legolide18,19,146�150 kufanele kube yingxenye ebalulekile yalezi zifundo nokuthi noma yikuphi ukonakala okunempilo okulandelanayo ezigulini ezizila ukudla kanye/noma ama-FMD kulungiswe ngokushesha.

iziphetho

Ukuzila ukudla ngezikhathi ezithile noma ama-FMD abonisa ngokungaguquki imiphumela enamandla yokulwa nomdlavuza kumamodeli omdlavuza wamagundane okuhlanganisa amandla okwenza i-chemoradiotherapy nama-TKIs ibe namandla kanye nokuvusa ukungatheleleki komdlavuza. Imijikelezo ye-FMD ingenzeka kakhulu kunemithi yokudla engapheli ngoba ivumela iziguli ukuba zidle ukudla njalo ngesikhathi se-FMD, zigcine ukudla okuvamile phakathi kwemijikelezo futhi akuholeli ekulahlekelweni kwesisindo esinzima futhi okungenzeka kube nemiphumela elimazayo kumasosha omzimba kanye nezinhlelo ze-endocrine. Ngokuphawulekayo, njengemithi yokwelapha ezimele, ukuzila ukudla ngezikhathi ezithile noma imijikelezo ye-FMD ingase ibonise ukusebenza kahle okulinganiselwe ngokumelene nezimila ezisunguliwe. Eqinisweni, kumagundane, ukuzila ukudla noma ama-FMD kuthinta ukuqhubeka kwenani lomdlavuza ngokufanayo ne-chemotherapy, kodwa iyodwa, ayifani neze nomphumela otholakala ngokuhlanganiswa nezidakamizwa zomdlavuza ezingabangela ukusinda okungenamdlavuza11,59. Ngakho-ke, siphakamisa ukuthi kuyinhlanganisela yemijikelezo ye-FMD ngezikhathi ezithile ngokwelashwa okujwayelekile okubamba amandla aphezulu okugqugquzela ukusinda okungenamdlavuza ezigulini, njengoba kuphakanyiswe amamodeli wegundane11,59 (Fig. 3).

Le nhlanganisela ingase ibe namandla ikakhulukazi ngenxa yezizathu ezimbalwa: okokuqala, izidakamizwa zomdlavuza nezinye izindlela zokwelapha zingasebenza, kodwa ingxenye yeziguli ayiphenduli ngenxa yokuthi amangqamuzana omdlavuza athatha amasu ahlukile e-metabolic aholela ekusindeni. Lezi zindlela ezihlukile ze-metabolic zinzima kakhulu ukusekela ngaphansi kwezimo zokuzila noma ze-FMD ngenxa yokushoda noma izinguquko ku-glucose, ama-amino acid athile, ama-hormone, nezici zokukhula, kanye nakwezinye izindlela ezingaziwa eziholela ekufeni kweseli. Okwesibili, ukuzila ukudla noma ama-FMD kungavimbela noma kunciphise ukutholwa kokumelana. Okwesithathu, ukuzila ukudla noma ama-FMD avikela amangqamuzana avamile nezitho emiphumeleni emibi ebangelwa izinhlobonhlobo zezidakamizwa zomdlavuza. Ngokwesisekelo sobufakazi bokuqala kanye nomtholampilo bokuthi kungenzeka, ukuphepha nokusebenza ngempumelelo (ekwehliseni i-IGF1, amafutha e-visceral futhi izici eziyingozi zenhliziyo), ama-FMD abuye abonakale njengendlela esebenzayo yokudla okufanele ifundwe ekuvimbeleni umdlavuza. Inselele ebalulekile yesikhathi esizayo kuzoba ukukhomba labo izimila okuyilabo abazongenela ukhetho olungcono kakhulu lokuzuza ngokuzila ukudla noma kuma-FMD. Ngisho nasezinhlotsheni zomdlavuza ezibonakala zingasabeli kangako ekuzileni ukudla noma ama-FMD, kusengenzeka ukuhlonza izindlela zokumelana nokungenelela kanye nezidakamizwa ezikwazi ukubuyisela lokho kumelana. Ngakolunye uhlangothi, ukuqapha okwengeziwe kufanele kuthathwe nezinye izinhlobo zokudla, ikakhulukazi uma ama-kilojoule amaningi, njengoba kungaholela ekwandeni futhi kungavinjelwa. ukukhula yomdlavuza othile. Isibonelo, i-KD iyanda ukukhula yemodeli ye-melanoma ene-BRAF eguquliwe ku-mice123, futhi kwabikwa ukuthi isheshisa ukuqhubeka kwesifo kumodeli ye-AML yegundane72.

Ngaphezu kwalokho, kubalulekile ukusebenzisa ama-FMD ngokuqonda izindlela zokwenza, njengoba amandla abo. uma isetshenziswe ngokungalungile ingadala imiphumela engemihle. Isibonelo, lapho amagundane ezila ukudla futhi ephathwa nge-carcinogen enamandla ngaphambi kokuncelisa, lokhu kwaholela ekukhuleni kwe-foci engavamile esibindini, ikholoni. futhi i-rectum uma iqhathaniswa namagundane angalizili151,152. Nakuba izindlela ezihilelekile kulo mphumela zingaqondakali, futhi lezi foci kungenzeka ukuthi azizange zibangele izimila, lezi zifundo ziphakamisa ukuthi isikhathi esincane samahora angu-24�48 phakathi kokwelashwa ngamakhemikhali kanye nokubuyela ekudleni okuvamile kubalulekile ukuze kugwenywe ukuhlanganisa izimpawu zokukhula ezikhona ngesikhathi sokuncelisa ngemva kokuzila ukudla okunamazinga aphezulu ezidakamizwa ezinobuthi njenge-chemotherapy. Izifundo zomtholampilo zokuzila ukudla noma i-FMD ezigulini ezithola i-chemotherapy zisekela ukuba nokwenzeka kwayo kanye nokuphepha okuphelele52,53,58,61. Esivivinyweni esincane esingahleliwe esibhalise iziguli ze-34, i-FMD yasiza iziguli ukuthi zigcine izinga lempilo yazo ngesikhathi sokwelashwa ngamakhemikhali nokunciphisa ukukhathala61. Ngaphezu kwalokho, idatha yokuqala iphakamisa amandla okuzila ukudla noma ama-FMD ukunciphisa ukwelashwa ngamakhemikhali Ukulimala kwe-DNA kumaseli anempilo ezigulini52,53.

Izifundo zomtholampilo eziqhubekayo zama-FMD ezigulini ezinomdlavuza63,65�68 zizohlinzeka ngezimpendulo eziqinile zokuthi ingabe ukuchaza ama-FMD ngezikhathi ezithile kuhlanganiswe nama-ejenti avamile e-anticancer kusiza ukuthuthukisa ukubekezelelana nomsebenzi wakamuva. Kubalulekile ukucabangela ukuthi ama-FMD ngeke aphumelele ekunciphiseni imiphumela emibi yokwelashwa komdlavuza kuzo zonke iziguli futhi ngeke asebenze ukuthuthukisa ukusebenza kahle kwazo zonke izindlela zokwelapha, kodwa anamandla amakhulu okwenza kanjalo okungenani ingxenye ethile futhi mhlawumbe ingxenye enkulu yeziguli nezidakamizwa. Iziguli ezibuthaka noma ezingondlekile noma iziguli ezisengozini yokungondleki akufanele zibhaliswe ezifundweni zemitholampilo zokuzila ukudla noma ama-FMD, futhi isimo sokudla okunempilo kwesiguli kanye ne-anorexia kufanele kuqashwe ngokucophelela kuzo zonke izivivinyo zomtholampilo. Okufanelekile ukudla amaprotheni, ama-fatty acids abalulekile, amavithamini futhi amaminerali ahlanganisiwe, lapho kunokwenzeka, nokukhanya kanye/noma umsebenzi womzimba omaphakathi ohloselwe ukukhulisa imisipha Mass kufanele kusetshenziswe phakathi kokuzila ukudla noma imijikelezo ye-FMD ukuze iziguli zigcine isisindo somzimba onempilo enempilo18,19. Le ndlela yokudla ye-multimodal izokwandisa izinzuzo zokuzila ukudla noma ama-FMD ngenkathi ngesikhathi esifanayo ivikela iziguli ekungondleki.

References:

Ukudla Okune-Carb Ephansi Okuboshelwe Ku-Heart Rhythm Disorder

by UDkt Alex Jimenez | Ukuzila, Nutrition, ProLon

Abantu abathola iphesenti eliphansi kakhulu lekhalori yabo yansuku zonke kumacarbohydrates, njengezithelo, okusanhlamvu, nemifino enesitashi, maningi amathuba okuthi bathuthuke i-atrial fibrillation, noma i-AFib. Lolu daba lwezempilo lungenye yezinkinga ezivame kakhulu zesigqi senhliziyo, ngokocwaningo olusha olwethulwa e-American College of Cardiology's 68th Annual Scientific Session.

Ucwaningo locwaningo luhlole amarekhodi ezempilo abantu abacishe babe ngu-14,000 athathe amashumi amabili noma ngaphezulu eminyaka. Abacwaningi balethe idatha evela ku-Atherossteosis Risk in Communities, noma i-ARIC, ucwaningo locwaningo olulawulwa yi-National Institutes of Health olwaqhutshwa kusukela ku-1985 kuya ku-2016. Cishe kubahlanganyeli be-1,900 abatholwe ngokusebenzisa iminyaka engu-22 yokulandelela, iningi. kubo bahlonzwe nge-AFib ngabacwaningi. Imininingwane yocwaningo locwaningo ichazwe ngezansi.

I-AFib kanye nama-carbohydrate

Abahlanganyeli bocwaningo bacelwe ukuthi babike ukusetshenziswa kwansuku zonke kwezinhlobo zokudla ezihlukene ezingama-66 kunhlolovo. Abacwaningi basebenzise lolu lwazi ukukala iphesenti lamakhalori avela kumakhabhohayidrethi ekudlalweni kwekhalori komhlanganyeli ngamunye. Ama-carbohydrate aqukethwe cishe engxenyeni yamakholori ansuku zonke adliwa abahlanganyeli.

Abacwaningi babe sebehlukanisa abahlanganyeli baba ngamaqembu amathathu ahlukene ahlukaniswa ngokudla okuphansi, okulinganiselwe, nokuphezulu kwe-carbohydrate, okumelela ukudla lapho ama-carbohydrate ahlanganisa amaphesenti angaphansi kwe-44.8 wekhalori yabo yansuku zonke, alandelwa ngamaphesenti angu-44.8 kuya ku-52.4, futhi ekugcineni lapho ama-carbohydrate ahlanganisa ngaphezu kwamaphesenti angu-52.4 ama-calories abo nsuku zonke, ngokulandelana.

Ababambiqhaza ababika ukusetshenziswa kwe-carbohydrate encishisiwe yibo ababenethuba eliphakeme kakhulu lokuthuthukisa i-AFib, ngokusho kwabacwaningi. Njengoba izibalo zocwaningo locwaningo zabonisa kamuva, laba ababambiqhaza nabo babenamathuba angamaphesenti angu-18 okuqhamuka ne-AFib uma kuqhathaniswa nalabo abadla ama-carbohydrate alinganiselwe kanye namaphesenti angu-16 okungenzeka ukuthi baqhamuke ne-AFib uma kuqhathaniswa nalabo abadla kakhulu ama-carbohydrate. Okunye ukudla kungasiza ekunciphiseni ingozi yokuphazamiseka kwesigqi senhliziyo.

Uhlobo lwama-carbohydrate oludlayo lungenza umehluko omkhulu empilweni yakho yonke kanye nempilo yakho. Ama-carbohydrate ayinkimbinkimbi agaywa kancane kakhulu kunama-carbohydrate alula futhi akhulula ukuphuma kancane kancane kukashukela, noma i-glucose, ingene egazini. Ama-carbohydrate ayinkimbinkimbi, avame ukubizwa ngokuthi ukudla "okunesitashi", afaka okusanhlamvu, imifino enesitashi, okusanhlamvu okuphelele, kanye ne-fiber. Ngokocwaningo locwaningo esihlokweni esilandelayo, ukudla amanani aphansi ama-carbohydrate, ngokuvamile ahlanganisa izithelo, imifino, nokusanhlamvu, kungaba nomthelela ezifweni zenhliziyo, njenge-atrial fibrillation. Uma kukhulunywa ngama-carbohydrate, kubalulekile ukusebenzisa le macronutrient ebalulekile empilweni nempilo yonke.
UDkt. Alex Jimenez DC, CCST Insight

Ukudla okunomsoco kwe-AFib

Ukukhawulela ama-carbohydrate sekuphenduke uhlelo oludumile lokwehlisa isisindo. Izidlo eziningi, ezifana ne-Paleo kanye nokudla kwe-ketogenic, ziqokomisa ukusetshenziswa kwamaprotheni. Ngokusho kuka-Xiaodong Zhuang, MD, PhD, udokotela wezifo zenhliziyo kanye nomlobi oholayo wocwaningo, "Umthelela wesikhathi eside wokuvinjelwa kwama-carbohydrate usalokhu uphikisana, ikakhulukazi maqondana nomthelela wawo esifweni senhliziyo nemithambo yegazi." "Uma kucatshangelwa imiphumela engaba khona ku-arrhythmia, ucwaningo lwethu lubonisa ukuthi lolu hlelo oludumile lokulawula isisindo kufanele lunconywe ngokucophelela," esho esitatimendeni esishicilelwe yi-ACC.

Okutholakele kuhambisana nezifundo zocwaningo lwangaphambilini, eziningi zazo ezihlobanise ukudla okune-polyunsaturated kanye nama-carbohydrate amaningi okunethuba elikhulu lokufa. Nakuba ucwaningo lwangaphambilini lubonise ukuthi le ngxenye yokudla ithinte izinyathelo zomphumela ezitholiwe, ucwaningo ngokwalo aluzange lunqume lokhu okutholakele. "Ukudla okune-carbohydrate ephansi kuhlotshaniswa nengozi enkulu yokuthola i-AFib kungakhathalekile ukuthi hlobo luni lwamafutha noma amaprotheni asetshenziswa esikhundleni se-carbohydrate," kusho uZhuang.

"Izindlela ezimbalwa ezingenzeka zingachaza ukuthi kungani ukukhawulela ama-carbohydrate kungaba nomthelela ku-AFib," kusho uZhuang. Enye iwukuthi abantu abadla ukudla okune-carbohydrate ephansi bavame ukudla izithelo ezimbalwa, imifino, nokusanhlamvu. Ngaphandle kwalokhu kudla, abantu bangabhekana nokuvuvukala okusakazeke kabanzi, okuxhunywe ne-AFib. Ngokocwaningo locwaningo, aukuphawula Incazelo engaba khona ukuthi ukudla amafutha amaningi namaprotheni esikhundleni sokudla okunothe nge-carbohydrate kungaholela ekucindezelekeni kwe-oxidative, nayo exhunywe ku-AFib. Umphumela ungase uhlotshaniswe nengozi eyengeziwe yezinye izinhlobo zesifo senhliziyo nemithambo yegazi.

I-Longevity Diet Plan, eyethulwa encwadini kaDkt Valter Longo, iqeda ukusetshenziswa kokudla okucutshungulwayo okungabangela ukuvuvukala, ukukhuthaza inhlalakahle nokuphila isikhathi eside. Nakuba lolu hlelo lokudla lungagxili ekwehleni kwesisindo, ukugcizelelwa kohlelo lokudla isikhathi eside kusekudleni okunempilo. I-Longevity Diet Plan iye yaboniswa ukusiza ukwenza kusebenze ukuvuselelwa kwe-stem cell-based, ukunciphisa amafutha esisu, nokuvimbela ukulahlekelwa kwamathambo nemisipha okuhlobene nobudala, kanye nokwakha ukumelana nokuthuthukisa isifo senhliziyo.

Ukudla okulingisa ukuzila ukudla, noma i-FMD, kukuvumela ukuthi uthole izinzuzo zokuzila ukudla okungokwesiko ngaphandle kokuncisha umzimba wakho ukudla. Umehluko omkhulu we-FMD ukuthi esikhundleni sokuqeda ngokuphelele konke ukudla izinsuku ezimbalwa noma ngisho amasonto, ukhawulela kuphela ukudla kwakho kwekhalori izinsuku ezinhlanu ngaphandle kwenyanga. I-FMD ingenziwa kanye ngenyanga ukusiza ukukhuthaza impilo nempilo yonke.

Nakuba noma ubani engakwazi ukulandela i-FMD eyedwa, i I-ProLon� ukuzila ukudla okulingisa ukudla kunikeza uhlelo lokudla lwezinsuku ezi-5 olupakishwe ngakunye futhi lwalebula usuku ngalunye, olunikeza ukudla okudingayo kwe-FMD ngamanani anembile nezinhlanganisela. Uhlelo lokudla lwakhiwe ukudla osekulungele ukudliwa futhi okulula ukukulungisa, okusekelwe ezitshalweni, okuhlanganisa ama-bar, amasobho, ama-snacks, izithasiselo, i-concentrate yesiphuzo, namatiye. Ngaphambi kokuqala i- I-ProLon � ukuzila ukudla okulingisa ukudla, uhlelo lokudla lwezinsuku ezi-5, noma yiziphi izinguquko zendlela yokuphila ezichazwe ngenhla, sicela uqiniseke ukuthi ukhuluma nochwepheshe bezempilo ukuze uthole ukuthi lolu hlelo lokudla lukulungele yini.

Ngaphezu kwalokho, ucwaningo aluzange luqaphe ababambiqhaza abane-AFib engabonakali, noma abantu ababene-AFib kodwa abangakaze bangeniswe esibhedlela. Ayizange iphenye izinhlobo ezingaphansi ze-AFib, ngakho-ke akwaziwa ukuthi uma iziguli zazisemathubeni amaningi kakhulu okuba neziqephu zokuphikelela noma ze-arrhythmia AFib. U-Zhuang ubike ukuthi ucwaningo locwaningo aluzange lubonise imbangela nomphumela. Kungase kudingeke isilingo esingahleliwe ukuze kuqinisekiswe ukuxhumana phakathi kwe-AFib nokudla kwama-carbohydrate ukuze kuhlolwe umphumela kubantu abahlukahlukene kakhulu.

Ububanzi bolwazi lwethu bukhawulelwe ku-chiropractic, izinkinga zempilo yomgogodla, nezindatshana zemithi esebenzayo, izihloko, nezingxoxo. Ukuze uqhubeke uxoxa ngesihloko esingenhla, sicela ukhululeke ukubuza uDkt. Alex Jimenez noma usithinte ku 915-850-0900 .

Ikhethwe nguDkt Alex Jimenez

Inkinobho Yokushaya Manje Okuhlaza H .png

Ingxoxo Yesihloko Eyengeziwe: Ubuhlungu Obubuhlungu Emuva

Ukuhlungu obusemhlane ingenye yezimbangela ezivame kakhulu zokukhubazeka nokuphuthelwa izinsuku emsebenzini emhlabeni wonke. Ubuhlungu beqolo bubalulwe kusizathu sesibili esivame kakhulu sokuvakashelwa kwehhovisi likadokotela, okungaphezu nje kwezifo eziphezulu zokuphefumula. Cishe amaphesenti angu-80 abantu azothola ubuhlungu bokubuyela emuva okungenani kanye kukho konke ukuphila kwabo. Umgogodla wakho uyisakhiwo esiyinkimbinkimbi esakhiwe ngamathambo, amalunga, imigqa, nemisipha, phakathi kwezinye izicubu ezithambile. Ukulimala kanye/noma izimo ezimbi kakhulu, njenge i-discni herniated, ekugcineni kungaholela ezimpawu zobuhlungu beqolo. Ukulimala kwezemidlalo noma ukulimala kwengozi yemoto ngokuvamile kuyimbangela evame kakhulu yobuhlungu beqolo, noma kunjalo, ngezinye izikhathi ukunyakaza okulula kakhulu kungaba nemiphumela ebuhlungu. Ngenhlanhla, ezinye izindlela zokwelapha, njengokunakekelwa kwe-chiropractic, zingasiza ekudambiseni izinhlungu emuva ngokusebenzisa ukulungiswa komgogodla kanye nokuphathwa ngesandla, ekugcineni kuthuthukise ukukhululeka kobuhlungu.

Ngokuziqhenya, UDkt Alexander Jimenez yenza amafomula e-XYMOGEN atholakale ezigulini ezingaphansi kwethu kuphela.

Sicela ushayele ihhovisi lethu ukuze sinikeze ukubonisana nodokotela ukuze sifinyelele ngokushesha.

Uma uyisiguli se Umtholampilo Wokulimala Kwezokwelapha Nokwelashwa Kwe-Chiropractic, ungase ubuze mayelana ne-XYMOGEN ngokushaya ucingo 915-850-0900.

Ukuze kube lula kuwe futhi ubuyekeze i- XYMOGEN imikhiqizo sicela ubuyekeze isixhumanisi esilandelayo.*XYMOGEN-Ikhathalogi-Thwebula

* Zonke izinqubomgomo ze-XYMOGEN ezingenhla zisasebenza ngokuqinile.

***

Yeka Ukudla Lokhu futhi Umise Ubuhlungu Obungapheli

by UDkt Alex Jimenez | Ubuhlungu obungapheliyo, Ukuzila, ProLon

Ingabe ngezinye izikhathi uzwa sengathi ubuhlungu bakho obungapheli buba bubi nakakhulu ngemva kokudla ukudla okuthile? Eqinisweni, ucwaningo luye lwabonisa ukuthi ukudla izinhlobo eziningana zokudla kungadala impendulo yokuvuvukala emzimbeni womuntu. Futhi sonke siyazi ukuthi ukuvuvukala kungaba esinye sezimbangela eziyinhloko zokuqubuka kobuhlungu obungapheli. Ngaphambi kokuba sixoxe ngokudla okungabangela ukuvuvukala nokudla okungalwa nokuvuvukala, ake sixoxe ngokuthi kuyini ukuvuvukala nokuthi ungakukala kanjani ukuvuvukala.

Kuyini Ukuvuvukala?

Ukuvuvukala kuyindlela yokuzivikela yemvelo yamasosha omzimba. Isebenza ngokuvikela umzimba womuntu ekulimaleni, ekuguleni nasekuthelelekeni. Ukuvuvukala kusiza ukugcina impilo nempilo yonke. Ukungezwani komzimba nakho kungabangela ukuvuvukala. Uma ulimele noma unezifo, ungabona izimpawu zokuvuvukala: noma ukuvuvukala, okubomvu, namabala ashisayo. Nokho, ukuvuvukala kungase kwenzeke ngaphandle kwesizathu. Indlela ekahle yokuxilonga ukuvuvukala ukukala ama-biomarker athile ngokuhlolwa kwegazi.

I-C-reactive protein, noma i-CRP, into ekhiqizwa isibindi, ingenye yezimpawu ezihamba phambili zokuvuvukala. Amazinga e-CRP ayanda njengoba ukuvuvukala kukhula, ngakho-ke, ungakwazi ukwazi okuningi mayelana nokuthi kwenzekani ngaphakathi komzimba wakho ngokubheka amazinga akho e-CRP. Ngokusho kwe-American Heart Association kanye neCenters for Disease Control and Prevention, ukuhlushwa kwe-CRP okungaphansi kwe-1.0 mg / L kuphakamisa ingozi ephansi yezinkinga zenhliziyo; phakathi kuka-1.0 kuya ku-3.0 mg/L kuphakamisa ingozi evamile yezinkinga zenhliziyo; futhi ngaphezu kuka-3.0 mg/L kuphakamisa ingozi enkulu yezinkinga zenhliziyo. Amazinga amakhulu e-CRP (ngaphezu kuka-10 mg/L) angase futhi aphakamise ingozi yokuthuthukisa ezinye izindaba zezempilo.

Amanye ama-biomarker afana nama-monocyte acushiwe, ama-cytokines, ama-chemokines, ama-adhesion molecule ahlukahlukene, i-adiponectin, i-fibrinogen, ne-serum amyloid alpha, amanye ama-biomarker angakalwa ngokuhlolwa kwegazi ukuze kutholakale ukuvuvukala. Izimpendulo ezivuthayo zihlanganisa umsebenzi wokuzwelana, ukucindezeleka kwe-oxidative, ukuqaliswa kwe-nuclear factor kappaB (NF-kB), nokukhiqizwa kwe-cytokine e-proinflammatory.

Amangqamuzana amhlophe egazi adlala indima ebalulekile emasosheni omzimba womuntu. Njalo lapho ibhaktheriya noma igciwane lingena egazini, amangqamuzana amhlophe egazi, noma ama-leukocyte, abona futhi abhubhise abahlaseli bangaphandle. Ungase ukholelwe ukuthi ukwanda kwamangqamuzana amhlophe egazi kungase kube yinzuzo njengoba amangqamuzana amhlophe egazi elwa nokutheleleka, nokho-ke, lokhu kungase kungabi njalo. Ukwanda kwamangqamuzana amhlophe egazi kungase kubonise ukuba khona kwenye inkinga yezempilo, nakuba inani elikhulu lamangqamuzana egazi amhlophe akuyona inkinga ngokwayo.

Ukudla Okubangela Ukuvuvukala

Akumangalisi ukuthi izinhlobo ezifanayo zokudla ezingabangela ukuvuvukala nazo ngokuvamile zibhekwa njengezimbi empilweni yethu, njengama-carbohydrate acwengiwe, namasoda kanye nenyama ebomvu, kanye nenyama egayiwe. Ukuvuvukala kuyindlela ebalulekile eyisisekelo eye yahlotshaniswa nengozi eyengeziwe yezifo ezingamahlalakhona ezifana nesifo sikashukela sohlobo 2 nesifo senhliziyo, phakathi kwezinye izindaba zezempilo.

Ukudla okungenampilo nakho kunomthelela ekuzuzeni isisindo, okuyisici esiyingozi sokuvuvukala. Ezifundweni eziningana zocwaningo, ngisho nangemva kokuba abacwaningi becabangela ukukhuluphala ngokweqile, ukuxhumana phakathi kokuvuvukala nalokhu kudla kwahlala, okubonisa ukuthi ukuzuza kwesisindo akusona isizathu sokuvuvukala. Okunye ukudla kunomphumela okhulayo ekuvuvukeni nasekusetshenzisweni kwe-caloric kwanda.

Ukudla okungabangela ukuvuvukala kuhlanganisa:

Ama-carbohydrate acwengekile, njengesinkwa esimhlophe namakhekhe
Amafrimu aseFrance nokunye ukudla okuthosiwe
Amasoda nezinye iziphuzo ezinoshukela
Inyama ebomvu njengamabhega nama-steaks kanye nenyama egayiwe njengezinja ezishisayo namasoseji
Imajarini, ukufinyeza, nesinqumelo

Ukudla Okulwa Nokuvuvukala

Ngaphandle kwalokho, kukhona ukudla okulwa nokuvuvukala, futhi nakho, izifo ezingapheli. Izithelo nemifino ethile, njengamajikijolo aluhlaza okwesibhakabhaka, ama-apula, nemifino enamaqabunga, iphezulu kuma-polyphenols nama-antioxidants, okuyizingxenye ezingase zibe nemiphumela yokulwa nokuvuvukala. Ucwaningo luphinde lwahlobanisa amantongomane nama-biomarker ancishisiwe okuvuvukala kanye nokuncipha kwengozi yesifo sikashukela nesifo senhliziyo. Ikhofi lingavikela nokuvuvukala, futhi. Khetha ukudla okuvimbela ukuvuvukala futhi ungathuthukisa impilo yakho nempilo yakho yonke. Khetha ukudla okuvuvukalayo futhi ungandisa ingozi yokuvuvukala nobuhlungu obungapheli.

Ukudla okungalwa nokuvuvukala kuhlanganisa:

utamatisi
Amafutha e-Olive
Imifino enamahlamvu aluhlaza, njengesipinashi, i-kale, namakholadi
Amantongomane afana nama-alimondi nama-walnuts
Izinhlanzi ezinamafutha, njenge-saumoni, i-tuna, i-mackerel, ne-sardine
Izithelo ezifana nama-strawberries, ama-blueberries, ama-cherries namawolintshi

Ochwepheshe bezempilo bafunda ukuthi enye yezindlela ezinkulu zokunciphisa ukuvuvukala iyatholakala. hhayi ekhabetheni lemithi, kodwa esiqandisini. Ukudla okulwa nokuvuvukala kungasiza ekugcineni ukwehlisa ukusabela komzimba womuntu okuvuvukalayo. Amasosha omzimba aqala ukuvuvukala ukuze avikele umzimba womuntu ekulimaleni, ekuguleni nasekuthelelekeni. Kodwa uma ukuvuvukala kuqhubeka, kungase kubangele izinkinga ezihlukahlukene zezempilo, kuhlanganise nezimpawu zobuhlungu obungapheli. Ucwaningo luye lwabonisa ukuthi ukudla okuthile kungaba nomthelela emiphumeleni yokuvuvukala emzimbeni womuntu.
UDkt. Alex Jimenez DC, CCST Insight

Izidlo Ezilwa Nokuvuvukala

Ukunciphisa ukuvuvukala, gxila ekulandeleni ukudla okunempilo jikelele. Uma ufuna ukudla okulwa nokuvuvukala, cabanga ngokulandela ukudla kwaseMedithera, okunezithelo, imifino, amantongomane, okusanhlamvu okuphelele, inhlanzi namafutha. I-Longevity Diet Plan, eyethulwa encwadini kaDkt Valter Longo, iphinde iqede ukudla okungabangela ukuvuvukala, ukukhuthaza inhlalakahle nokuphila isikhathi eside. Ukuzila ukudla, noma ukuvinjelwa kwe-caloric, sekuyisikhathi eside kwaziwa kunciphisa ukucindezeleka okwenziwe nge-oxidative futhi kubambezele izindlela zokuguga ezinhlobonhlobo zezinto eziphilayo.

Futhi uma ukuzila ukudla kungekona okwakho, uhlelo lokudla isikhathi eside lukaDkt. Valter Longo luhlanganisa nokudla kokulingisa ukuzila ukudla, noma i-FMD, ekuvumela ukuthi uthole izinzuzo zokuzila ukudla okuvamile ngaphandle kokuncisha umzimba wakho ukudla. Umehluko omkhulu we-FMD ukuthi esikhundleni sokuqeda konke ukudla izinsuku ezimbalwa noma ngisho amasonto, ukhawulela kuphela ukudla kwakho kwekhalori izinsuku ezinhlanu ngaphandle kwenyanga. I-FMD ingenziwa kanye ngenyanga ukusiza ukukhuthaza impilo yonke nokuphila kahle kanye nokusiza ukunciphisa ukuvuvukala nobuhlungu obungapheli.

Nakuba noma ubani engakwazi ukulandela i-FMD eyedwa, uDkt. Valter Longo unikeza I-ProLon� ukuzila ukudla okulingisa ukudla, uhlelo lokudla lwezinsuku ezi-5 olupakishwe ngakunye futhi lwanelebula ukuhlinzeka ngokudla okudingayo kwe-FMD ngamanani anembile nezinhlanganisela. Uhlelo lokudla luqukethe ukudla osekulungele ukudliwa futhi okulula ukukulungisa, okusekelwe ezitshalweni, okuhlanganisa ama-bar, amasobho, ukudla okulula, izithasiselo, i-concentrate yesiphuzo, namatiye. Nokho, bngaphambili ukuqala I-ProLon � ukuzila ukudla okulingisa ukudla, uhlelo lokudla lwezinsuku ezi-5, noma noma yikuphi ukuguqulwa kwendlela yokuphila okuchazwe ngenhla, sicela uqiniseke ukuthi ukhuluma nodokotela ukuze uthole ukuthi yikuphi ukwelashwa okubuhlungu okungapheli okulungile kuwe.

Ngaphezu kokunciphisa ukuvuvukala, ukudla okungokwemvelo, okungacutshungulwa kancane kungaba nemiphumela ebonakalayo empilweni yakho engokomzimba nengokomzwelo. Ububanzi bolwazi lwethu bukhawulelwe ku-chiropractic, izinkinga zempilo yomgogodla, nezindatshana zemithi esebenzayo, izihloko, nezingxoxo. Ukuze uqhubeke uxoxa ngesihloko esingenhla, sicela ukhululeke ukubuza uDkt. Alex Jimenez noma usithinte ku 915-850-0900 .

Ikhethwe nguDkt Alex Jimenez

Ingxoxo Yesihloko Eyengeziwe: Ubuhlungu Obubuhlungu Emuva

Ngokuziqhenya, UDkt Alexander Jimenez yenza amafomula e-XYMOGEN atholakale ezigulini ezingaphansi kwethu kuphela.

Sicela ushayele ihhovisi lethu ukuze sinikeze ukubonisana nodokotela ukuze sifinyelele ngokushesha.

Uma uyisiguli se Umtholampilo Wokulimala Kwezokwelapha Nokwelashwa Kwe-Chiropractic, ungase ubuze mayelana ne-XYMOGEN ngokushaya ucingo 915-850-0900.

Ukuze kube lula kuwe futhi ubuyekeze i- XYMOGEN imikhiqizo sicela ubuyekeze isixhumanisi esilandelayo.*XYMOGEN-Ikhathalogi-Thwebula

* Zonke izinqubomgomo ze-XYMOGEN ezingenhla zisasebenza ngokuqinile.

***

«Okufakiwe Okudala

Ithuluzi le-IFM elithi Thola Udokotela liyinethiwekhi enkulu yokudlulisela ku-Functional Medicine, edalelwe ukusiza iziguli ukuthi zithole odokotela be-Functional Medicine noma kuphi emhlabeni. I-IFM Certified Practitioners ibalwe kuqala emiphumeleni yosesho, inikezwe imfundo yabo ebanzi ku-Functional Medicine.

Ukubhukha ku-inthanethi nama-aphoyintimenti 24/7*

Udokotela Wezokwelapha Osebenzayo Oqinisekisiwe El Paso — Umhlinzeki Wemithi Esebenzayo Oqinisekisiwe*
Bonke Abahlinzeki basebenza ngaphakathi kwendawo esemthethweni futhi basungule umkhakha wokusebenza womtholampilo.*

I-Injury & Trauma Rehabilitation Specialists

I-PUSHAsRx® Trauma Rehabilitation Centre

Ongoti Bezempilo, Ezempilo Nokudla Okunempilo

Ukuzila Ukuzila Kuyithinta Kanjani Impilo Yokugaya Ku-Functional Neurology

Ukuhlolwa kokuzila ukudla kanye nempilo yokugaya ukudla

Ukuqonda Imiphumela Yokuzila

Ifomu Lokuhlola I-Neurotransmitter

Ingxoxo Yesihloko Eyengeziwe: Ubuhlungu Obungamahlalakhona

I-Neural Zoomer Plus Yezifo Zezinzwa

Ukuzwela Kokudla kwe-IgG & IgA Immune Response

I-Gut Zoomer Yokukhula Kwamagciwane Amathumbu Amancane (SIBO)

Amafomula Okwesekwa kwe-Methylation

I-Functional Neurology: Ukuzila ukudla kanye ne-Autophagy yempilo yokugaya ukudla

Ukuzila ukudla kanye ne-Autophagy Overview

Ukuzila Ukudla kanye Ne-Autophagy Isekela Impilo Yokugaya

Ifomu Lokuhlola I-Neurotransmitter

Ingxoxo Yesihloko Eyengeziwe: Ubuhlungu Obungamahlalakhona

I-Neural Zoomer Plus Yezifo Zezinzwa

Ukuzwela Kokudla kwe-IgG & IgA Immune Response

I-Gut Zoomer Yokukhula Kwamagciwane Amathumbu Amancane (SIBO)

Amafomula Okwesekwa kwe-Methylation

I-Functional Neurology: Isayensi Yokuzila Ukudla Kwempilo Yokugaya

Ukuqonda Uhlelo Lokugaya ukudla

Ukuvuvukala

Ukucindezeleka Oxidative

Ukuzila ukudla kanye ne-MMC Yezempilo Yokugaya

Ifomu Lokuhlola I-Neurotransmitter

Ingxoxo Yesihloko Eyengeziwe: Ubuhlungu Obungamahlalakhona

I-Neural Zoomer Plus Yezifo Zezinzwa

Ukuzwela Kokudla kwe-IgG & IgA Immune Response

I-Gut Zoomer Yokukhula Kwamagciwane Amathumbu Amancane (SIBO)

Amafomula Okwesekwa kwe-Methylation

Ukuqonda Ukuzila Ukudla Kwesikhashana

Ingabe uzizwa:

Kuyini Ukuzila?

Izindlela Ezihlukene

Isebenza kanjani?

Izinzuzo Zokuzila

Isiphetho

References:

Ukuzila Ukudla Nomdlavuza: Izindlela Zemolekyuli kanye Nesicelo Somtholampilo

Impendulo Yokuzila Okuhlelekile Neselula

Impendulo Ehlelekile Yokuzila

Impendulo Yeselula Ngokuzila Ukudla

Izindlela Zokudla Kuma-Cancer FMD

Izidlo ze-Ketogenic

Umkhawulo Wekhalori

Ukuzila ukudla nama-FMD Ekwelapheni: Imiphumela kuma-hormone namazinga e-metabolite

Ukumelana Nokucindezeleka Okuhlukile: Ukwandisa Ukubekezelelana Kwe-Chemotherapy

Ukuzwela Okuhlukile Kokucindezeleka: Ukwandisa Ukufa Kwamangqamuzana Omdlavuza

I-Antitumour Immunity Enhancement Ngokuzila ukudla noma i-FMD

Izidlo ze-Anticancer kumamodeli wegundane

Ukuzila ukudla kanye nama-FMD ku-Cancer Prevention

Ukusebenza Komtholampilo ku-Oncology

Izinselelo Emtholampilo

iziphetho

References:

Ukudla Okune-Carb Ephansi Okuboshelwe Ku-Heart Rhythm Disorder

I-AFib kanye nama-carbohydrate

Ukudla okunomsoco kwe-AFib

Ingxoxo Yesihloko Eyengeziwe: Ubuhlungu Obubuhlungu Emuva

Yeka Ukudla Lokhu futhi Umise Ubuhlungu Obungapheli

Kuyini Ukuvuvukala?

Ukudla Okubangela Ukuvuvukala

Ukudla Okulwa Nokuvuvukala

Izidlo Ezilwa Nokuvuvukala

Ingxoxo Yesihloko Eyengeziwe: Ubuhlungu Obubuhlungu Emuva

Ukubhukha ku-inthanethi nama-aphoyintimenti 24/7*

QEDA UMLANDO WOKU-INTANETHI 24/7*

Izindawo Zomtholampilo

Izindawo Ezengeziwe Zokunakekelwa Okuhlinzekwayo

IKHALENDA LEZENZAKALO: IMICIMBI EBUKHOMA KANYE NE-WEBINARS